UniProtKB - Q5PT50 (NTCP7_RAT)
Protein
Sodium/bile acid cotransporter 7
Gene
Slc10a7
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).By similarity
GO - Molecular functioni
- bile acid transmembrane transporter activity Source: UniProtKB
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- bone development Source: RGD
- cellular calcium ion homeostasis Source: RGD
- glycoprotein transport Source: UniProtKB
- Golgi vesicle transport Source: UniProtKB
- heparin biosynthetic process Source: RGD
- sodium ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/bile acid cotransporter 7Alternative name(s): Na(+)/bile acid cotransporter 7 Solute carrier family 10 member 7 |
Gene namesi | Name:Slc10a7 Synonyms:P7 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1564388, Slc10a7 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus membrane By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- cis-Golgi network Source: UniProtKB
- Golgi apparatus Source: RGD
- Golgi medial cisterna Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
- trans-Golgi network Source: UniProtKB
Plasma Membrane
- intrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | Cytoplasmic1 Publication | 10 | |
Transmembranei | 11 – 31 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 32 – 37 | Extracellular1 Publication | 6 | |
Transmembranei | 38 – 58 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 59 – 71 | Cytoplasmic1 PublicationAdd BLAST | 13 | |
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 93 – 116 | Extracellular1 PublicationAdd BLAST | 24 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 | Cytoplasmic1 Publication | 1 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 160 – 163 | Extracellular1 Publication | 4 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 201 | Cytoplasmic1 PublicationAdd BLAST | 17 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 223 – 234 | Extracellular1 PublicationAdd BLAST | 12 | |
Transmembranei | 235 – 255 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 256 – 270 | Cytoplasmic1 PublicationAdd BLAST | 15 | |
Transmembranei | 271 – 291 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 292 – 298 | Extracellular1 Publication | 7 | |
Transmembranei | 299 – 319 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 320 – 340 | Cytoplasmic1 PublicationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278252 | 1 – 340 | Sodium/bile acid cotransporter 7Add BLAST | 340 |
Proteomic databases
PaxDbi | Q5PT50 |
Expressioni
Tissue specificityi
Strongly expressed in liver, adrenal gland, small intestine and colon. Moderately expressed in heart, lung, kidney and spleen. Weakly expressed in brain.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000011991, Expressed in stomach and 20 other tissues |
Genevisiblei | Q5PT50, RN |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4821, Eukaryota |
GeneTreei | ENSGT00390000011932 |
HOGENOMi | CLU_039013_0_0_1 |
InParanoidi | Q5PT50 |
OMAi | FFFYGLK |
OrthoDBi | 949808at2759 |
PhylomeDBi | Q5PT50 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR038770, Na+/solute_symporter_sf IPR016833, Put_Na-Bile_cotransptr |
PANTHERi | PTHR18640, PTHR18640, 1 hit |
Pfami | View protein in Pfam PF13593, SBF_like, 1 hit |
PIRSFi | PIRSF026166, UCP026166, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5PT50-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLLERVRKE WFMVGIVVAI GAAKLEPSVG VNGGPLKPEI TVSYIAVATI
60 70 80 90 100
FFNSGLSLKT EELTSALVHL KLHLFIQVFT LAFFPTTIWL FLQLLSVTSI
110 120 130 140 150
NEWLLKGLQT VGCMPPPVSS AVILTKAVGG NEAAAIFNSA FGSFLGIVVT
160 170 180 190 200
PVLLLLFLGS SSSVPFTSIF SQLFMTVVVP LVIGQIVRRY IKDWLERKKP
210 220 230 240 250
PFGVVSSSVL LMIIYTTFCD TFSNPNIDLD KFSLILILFI IVSIQLSFML
260 270 280 290 300
LTFVFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI
310 320 330 340
SLPLLIYHPA QILLGSVLVP TIKSWMVSRQ KGVKLTRPTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY825929 mRNA Translation: AAV80712.1 |
RefSeqi | NP_001010948.1, NM_001010948.1 |
Genome annotation databases
Ensembli | ENSRNOT00000015985; ENSRNOP00000015985; ENSRNOG00000011991 |
GeneIDi | 291942 |
KEGGi | rno:291942 |
UCSCi | RGD:1564388, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY825929 mRNA Translation: AAV80712.1 |
RefSeqi | NP_001010948.1, NM_001010948.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015985 |
Proteomic databases
PaxDbi | Q5PT50 |
Genome annotation databases
Ensembli | ENSRNOT00000015985; ENSRNOP00000015985; ENSRNOG00000011991 |
GeneIDi | 291942 |
KEGGi | rno:291942 |
UCSCi | RGD:1564388, rat |
Organism-specific databases
CTDi | 84068 |
RGDi | 1564388, Slc10a7 |
Phylogenomic databases
eggNOGi | KOG4821, Eukaryota |
GeneTreei | ENSGT00390000011932 |
HOGENOMi | CLU_039013_0_0_1 |
InParanoidi | Q5PT50 |
OMAi | FFFYGLK |
OrthoDBi | 949808at2759 |
PhylomeDBi | Q5PT50 |
Miscellaneous databases
PROi | PR:Q5PT50 |
Gene expression databases
Bgeei | ENSRNOG00000011991, Expressed in stomach and 20 other tissues |
Genevisiblei | Q5PT50, RN |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR038770, Na+/solute_symporter_sf IPR016833, Put_Na-Bile_cotransptr |
PANTHERi | PTHR18640, PTHR18640, 1 hit |
Pfami | View protein in Pfam PF13593, SBF_like, 1 hit |
PIRSFi | PIRSF026166, UCP026166, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTCP7_RAT | |
Accessioni | Q5PT50Primary (citable) accession number: Q5PT50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | January 4, 2005 | |
Last modified: | December 2, 2020 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families