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Protein

Mediator of DNA damage checkpoint protein 1

Gene

Mdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, DNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of DNA damage checkpoint protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mdc1
Synonyms:Kiaa0170
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3525201 Mdc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963181 – 1707Mediator of DNA damage checkpoint protein 1Add BLAST1707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphothreonineBy similarity1
Modified residuei146PhosphothreonineBy similarity1
Modified residuei168PhosphoserineCombined sources1
Modified residuei176PhosphoserineBy similarity1
Modified residuei298PhosphoserineBy similarity1
Modified residuei300PhosphothreonineBy similarity1
Modified residuei313PhosphoserineBy similarity1
Modified residuei315PhosphothreonineBy similarity1
Modified residuei360PhosphoserineBy similarity1
Modified residuei362PhosphothreonineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei387PhosphothreonineBy similarity1
Modified residuei398PhosphoserineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei425PhosphoserineBy similarity1
Modified residuei438PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei444PhosphothreonineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei470PhosphothreonineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei735PhosphoserineBy similarity1
Modified residuei750PhosphoserineBy similarity1
Modified residuei769N6-acetyllysineBy similarity1
Modified residuei885PhosphoserineBy similarity1
Modified residuei929PhosphoserineBy similarity1
Modified residuei962PhosphoserineBy similarity1
Modified residuei991PhosphoserineBy similarity1
Modified residuei1056PhosphothreonineCombined sources1
Modified residuei1104PhosphoserineCombined sources1
Modified residuei1126PhosphoserineCombined sources1
Modified residuei1128PhosphoserineCombined sources1
Modified residuei1132PhosphothreonineCombined sources1
Modified residuei1173PhosphothreonineBy similarity1
Modified residuei1234PhosphothreonineBy similarity1
Modified residuei1297PhosphothreonineCombined sources1
Modified residuei1298PhosphothreonineCombined sources1
Modified residuei1327PhosphoserineBy similarity1
Modified residuei1352PhosphothreonineBy similarity1
Modified residuei1359PhosphoserineBy similarity1
Modified residuei1375PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1418Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1435PhosphoserineCombined sources1
Modified residuei1436PhosphoserineCombined sources1
Modified residuei1439PhosphoserineCombined sources1
Modified residuei1443PhosphoserineCombined sources1
Cross-linki1461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki1461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1480PhosphothreonineCombined sources1
Modified residuei1496N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated upon exposure to ionizing radiation (IR), ultraviolet radiation (UV), and hydroxyurea (HU). Phosphorylation in response to IR requires ATM, NBN, and possibly CHEK2. Also phosphorylated during the G2/M phase of the cell cycle and during activation of the mitotic spindle checkpoint. Phosphorylation at Thr-4 by ATM stabilizes and enhances homodimerization via the FHA domain (By similarity).By similarity
Sumoylation at Lys-1461 by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.By similarity
Ubiquitinated by RNF4, leading to proteasomal degradation; undergoes 'Lys-48'-linked polyubiquitination.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5PSV9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5PSV9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5PSV9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5PSV9

PeptideAtlas

More...
PeptideAtlasi
Q5PSV9

PRoteomics IDEntifications database

More...
PRIDEi
Q5PSV9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5PSV9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5PSV9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_MDC1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with several proteins involved in the DNA damage response, although not all these interactions may be direct. Interacts with CHEK2, which requires ATM-mediated phosphorylation within the FHA domain of CHEK2. Interacts constitutively with the BRCA1-BARD1 complex, SMC1A and TP53BP1. Interacts with ATM and FANCD2, and these interactions are reduced upon DNA damage. Also interacts with the PRKDC complex, composed of XRCC6/KU70, XRCC5/KU80 and PRKDC/XRCC7. This interaction may be required for PRKDC autophosphorylation, which is essential for DNA double strand break (DSB) repair. When phosphorylated by ATM, interacts with RNF8 (via FHA domain). Interacts with CEP164. When phosphorylated, interacts with APTX (via FHA-like domain) (By similarity). Interacts with H2AFX, which requires phosphorylation of H2AFX. Interacts with the MRN complex, composed of MRE11, RAD50, and NBN.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
232163, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000080949

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11707
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VA1X-ray1.74A/B29-139[»]
3VA4X-ray1.54A/B29-139[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5PSV9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5PSV9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 105FHAPROSITE-ProRule annotationAdd BLAST52
Domaini1510 – 1588BRCT 1PROSITE-ProRule annotationAdd BLAST79
Domaini1609 – 1700BRCT 2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 150Interaction with CHEK2By similarityAdd BLAST150
Regioni2 – 222Interaction with the MRN complexBy similarityAdd BLAST221

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi995 – 1394Pro-richAdd BLAST400

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Tandemly repeated BRCT domains are characteristic of proteins involved in DNA damage signaling. In MDC1, these repeats are required for localization to chromatin which flanks sites of DNA damage marked by 'Ser-139' phosphorylation of H2AFX (By similarity).By similarity

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2043 Eukaryota
ENOG4111RPS LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113506

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080567

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5PSV9

KEGG Orthology (KO)

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KOi
K20780

Database of Orthologous Groups

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OrthoDBi
670424at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5PSV9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00027 BRCT, 1 hit
cd00060 FHA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.10190, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00498 FHA, 1 hit
PF16770 RTT107_BRCT_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00292 BRCT, 2 hits
SM00240 FHA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit
SSF52113 SSF52113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 1 hit
PS50006 FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q5PSV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESTQVIDWD AEEEEETELS SGSLGYSVEP IGQLRLFSGT HGPERDFPLY
60 70 80 90 100
LGKNVVGRSP DCSVALPFPS ISKQHAVIEI SAWNKAPILQ DCGSLNGTQI
110 120 130 140 150
VKPPRVLPPG VSHRLRDQEL ILFADFPCQY HRLDVPPPLV PRSLLTIEKT
160 170 180 190 200
PRIRIESQNS RVLLAADSEE EGDFPSGRCV ANGQRNTASP SATVVPESDE
210 220 230 240 250
EVSSPAPSVP GPSSPFGLGS DTDEEQGQQP GVEESSLADS SGAAGEAEQP
260 270 280 290 300
EANGTTAGIQ AQPTEHKLKD TKVKKEAGRA GVSDGSVLER SPTLGEDSDT
310 320 330 340 350
EVDEDHKPGF ADSETDVEEE RIPVTPPVAP VKKNQVLLAV GIGDPEAPGV
360 370 380 390 400
AHLQDCLAGS GTDVEDKTAL DVPLERNHTP MVINSDTDEE EEEEEEVSAA
410 420 430 440 450
LTLAHLKERG IGLWSRDPGA EEVKSQPQVL VEQSQSASGR DSDTDVEEES
460 470 480 490 500
SGRKREIIPD SPMDVDEALT VTQPESQPPR RPNDADEYMD MSSPGSHLVV
510 520 530 540 550
NQASFAVVGK TRAQVEEEVP GPSVILGEKH QVPLEGAQPP EEAWETAVQE
560 570 580 590 600
GSSSPEAAAS VRPSQQPVAE DAGTECATAV SEQESTLEVR SQSGSPAAPV
610 620 630 640 650
EQVVIHTDTS GDPTLPQREG AQTPTGRERE AHVGRTKSAK ECCDAEPEDL
660 670 680 690 700
CLPATQCFVE GESQHPEAVQ SLENEPTQLF PCTLPQEPGP SHLSLQTPGA
710 720 730 740 750
DTLDVPWEVL ATQPFCLREQ SETSELHEAH GSQPSLPREP PGHQHLVHTS
760 770 780 790 800
PVHTELLRIE GREIQTVEKA MGIPKEMADR MTPEREPLER EIRGRTENSE
810 820 830 840 850
RDVIGEELIQ GTKDREPKKV LARDSQRKEA DKDLEGNRES LEVEIEMSKD
860 870 880 890 900
SQKRERKVEK PEPKREWEPA DLEVTPDRGV TEEGSHDQKG QIASLTLKPG
910 920 930 940 950
VGVKDLEGLA SAPIITGSQA DGGKGDPLSP GRQQRGRLSC QTTPAGKASR
960 970 980 990 1000
GDPEPPDHCL FSSVPEASTQ SLLTSQSQKQ STPQPLFSTS SSEIPLPESL
1010 1020 1030 1040 1050
HTKPNVRPRR SSRMTPSPHS SAALKPNTTC PTNQPAASRP TSRPTRGRAN
1060 1070 1080 1090 1100
RSSTRTPELI VPVDPELQPS TSTEQPVIPK LTSQVTEGRV QMPEPLLTGP
1110 1120 1130 1140 1150
EIQSPTSTEQ SVTPDRKPRA TRGRPSKSPN KTPEPLISTG PELQPPTSIE
1160 1170 1180 1190 1200
QPVIPKPTSR VTRGRPRKSS VRTPESVVST GPELQPLTSI EQPVIPEPRA
1210 1220 1230 1240 1250
TRGRPSKSSI KTPESVVPTG PELQPLTSAK QPVTPNLTSR ASRGRSSKSI
1260 1270 1280 1290 1300
RTPEPVVQTG PEFHPSTSTE QPDTREPSSQ ARTRRSAVKT PEASVPTTPE
1310 1320 1330 1340 1350
LQPFTSKKQP APKPTALVTQ GRTYKPSTED CESVGPVAPD FEPSTSTDHL
1360 1370 1380 1390 1400
VTPKVTDQSL TLQSSPLSAS PVSSTPDLKP PVPIAQPVTP EPIPQANHQR
1410 1420 1430 1440 1450
KRRAAGKQGS RTVPLGHKSY SALSEPEPQS SASQSSGASE ADSPRQKRPR
1460 1470 1480 1490 1500
RQASQKTVVI KEEPVETEVK EEPQETAIPT PEKRKRDHAE EVTQGKPTRS
1510 1520 1530 1540 1550
RRTKPNQETA PKVLFTGVMD SRGERAVLAL GGSLASSVNE ASHLVTDRIR
1560 1570 1580 1590 1600
RTVKFLCALG KGIPILSLNW LYQSRKAGCF LPPDDYLVTD PEQEKNFSFS
1610 1620 1630 1640 1650
LRDSLCRARE RRLLEDYEIH VTPGVQPPPP QMGEIISCCG GTFLPSMPHS
1660 1670 1680 1690 1700
YKLHRVIITC TEDLPRCAIP SRLGLPLLSP EFLLTGVLKQ EATPEAFVLS

NLEMSST
Length:1,707
Mass (Da):184,670
Last modified:January 4, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6ECCD30BBED265D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QK89E9QK89_MOUSE
Mediator of DNA damage checkpoint p...
Mdc1
1,708Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UX64G3UX64_MOUSE
Mediator of DNA damage checkpoint p...
Mdc1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCY4A0A286YCY4_MOUSE
Mediator of DNA damage checkpoint p...
Mdc1
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti396E → EE in AAH94363 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY826432 Genomic DNA Translation: AAV85449.1
BC085140 mRNA Translation: AAH85140.1
BC094363 mRNA Translation: AAH94363.1
AK129074 mRNA Translation: BAC97884.1

NCBI Reference Sequences

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RefSeqi
NP_001010833.2, NM_001010833.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.218511

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
240087

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:240087

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY826432 Genomic DNA Translation: AAV85449.1
BC085140 mRNA Translation: AAH85140.1
BC094363 mRNA Translation: AAH94363.1
AK129074 mRNA Translation: BAC97884.1
RefSeqiNP_001010833.2, NM_001010833.2
UniGeneiMm.218511

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VA1X-ray1.74A/B29-139[»]
3VA4X-ray1.54A/B29-139[»]
ProteinModelPortaliQ5PSV9
SMRiQ5PSV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232163, 6 interactors
STRINGi10090.ENSMUSP00000080949

PTM databases

iPTMnetiQ5PSV9
PhosphoSitePlusiQ5PSV9

Proteomic databases

EPDiQ5PSV9
jPOSTiQ5PSV9
MaxQBiQ5PSV9
PaxDbiQ5PSV9
PeptideAtlasiQ5PSV9
PRIDEiQ5PSV9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi240087
KEGGimmu:240087

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9656
MGIiMGI:3525201 Mdc1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG2043 Eukaryota
ENOG4111RPS LUCA
HOGENOMiHOG000113506
HOVERGENiHBG080567
InParanoidiQ5PSV9
KOiK20780
OrthoDBi670424at2759
PhylomeDBiQ5PSV9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Mdc1 mouse

Protein Ontology

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PROi
PR:Q5PSV9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

CleanExiMM_MDC1

Family and domain databases

CDDicd00027 BRCT, 1 hit
cd00060 FHA, 1 hit
Gene3Di3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF16770 RTT107_BRCT_5, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 2 hits
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50006 FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDC1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5PSV9
Secondary accession number(s): Q52KG1, Q5U4D3, Q6ZQH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: January 4, 2005
Last modified: January 16, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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