UniProtKB - Q5PSV4 (BRM1L_HUMAN)
Breast cancer metastasis-suppressor 1-like protein
BRMS1L
Functioni
Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.
1 PublicationGO - Molecular functioni
- histone deacetylase binding Source: GO_Central
GO - Biological processi
- histone deacetylation Source: GO_Central
- negative regulation of cell migration Source: ComplexPortal
- negative regulation of stem cell population maintenance Source: ComplexPortal
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- negative regulation of transforming growth factor beta receptor signaling pathway Source: ComplexPortal
- positive regulation of stem cell population maintenance Source: ComplexPortal
- regulation of growth Source: UniProtKB-KW
Keywordsi
Molecular function | Repressor |
Biological process | Growth regulation, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q5PSV4 |
SignaLinki | Q5PSV4 |
Names & Taxonomyi
Protein namesi | Recommended name: Breast cancer metastasis-suppressor 1-like proteinAlternative name(s): BRMS1-homolog protein p40 BRMS1-like protein p40 |
Gene namesi | Name:BRMS1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20512, BRMS1L |
MIMi | 618514, gene |
neXtProti | NX_Q5PSV4 |
VEuPathDBi | HostDB:ENSG00000100916 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: ComplexPortal
- Sin3 complex Source: ComplexPortal
- Sin3-type complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84312 |
OpenTargetsi | ENSG00000100916 |
PharmGKBi | PA134968356 |
Miscellaneous databases
Pharosi | Q5PSV4, Tbio |
Genetic variation databases
BioMutai | BRMS1L |
DMDMi | 158706476 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305309 | 1 – 323 | Breast cancer metastasis-suppressor 1-like proteinAdd BLAST | 323 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 197 | PhosphoserineCombined sources | 1 | |
Cross-linki | 240 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 246 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q5PSV4 |
jPOSTi | Q5PSV4 |
MassIVEi | Q5PSV4 |
MaxQBi | Q5PSV4 |
PaxDbi | Q5PSV4 |
PeptideAtlasi | Q5PSV4 |
PRIDEi | Q5PSV4 |
ProteomicsDBi | 3426 63603 [Q5PSV4-1] |
PTM databases
GlyGeni | Q5PSV4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q5PSV4 |
PhosphoSitePlusi | Q5PSV4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100916, Expressed in frontal cortex and 217 other tissues |
ExpressionAtlasi | Q5PSV4, baseline and differential |
Genevisiblei | Q5PSV4, HS |
Organism-specific databases
HPAi | ENSG00000100916, Low tissue specificity |
Interactioni
Subunit structurei
Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L.
Interacts with HDAC and SIN3A.
1 PublicationBinary interactionsi
Q5PSV4
GO - Molecular functioni
- histone deacetylase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 124038, 97 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q5PSV4 |
IntActi | Q5PSV4, 62 interactors |
MINTi | Q5PSV4 |
STRINGi | 9606.ENSP00000216807 |
Miscellaneous databases
RNActi | Q5PSV4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | DisorderedSequence analysisAdd BLAST | 56 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 52 – 84 | Sequence analysisAdd BLAST | 33 | |
Coiled coili | 149 – 180 | Sequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 22 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 23 – 50 | Acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4466, Eukaryota |
GeneTreei | ENSGT00940000158921 |
HOGENOMi | CLU_050862_2_0_1 |
InParanoidi | Q5PSV4 |
OMAi | ICIDRKD |
OrthoDBi | 1456563at2759 |
PhylomeDBi | Q5PSV4 |
TreeFami | TF323740 |
Family and domain databases
InterProi | View protein in InterPro IPR013907, Sds3 |
PANTHERi | PTHR21964, PTHR21964, 1 hit |
Pfami | View protein in Pfam PF08598, Sds3, 1 hit |
SMARTi | View protein in SMART SM01401, Sds3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPVHSRGDKK ETNHHDEMEV DYAENEGSSS EDEDTESSSV SEDGDSSEMD
60 70 80 90 100
DEDCERRRME CLDEMSNLEK QFTDLKDQLY KERLSQVDAK LQEVIAGKAP
110 120 130 140 150
EYLEPLATLQ ENMQIRTKVA GIYRELCLES VKNKYECEIQ ASRQHCESEK
160 170 180 190 200
LLLYDTVQSE LEEKIRRLEE DRHSIDITSE LWNDELQSRK KRKDPFSPDK
210 220 230 240 250
KKPVVVSGPY IVYMLQDLDI LEDWTTIRKA MATLGPHRVK TEPPVKLEKH
260 270 280 290 300
LHSARSEEGR LYYDGEWYIR GQTICIDKKD ECPTSAVITT INHDEVWFKR
310 320
PDGSKSKLYI SQLQKGKYSI KHS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VRR2 | F8VRR2_HUMAN | Breast cancer metastasis-suppressor... | BRMS1L | 48 | Annotation score: | ||
H0YHD0 | H0YHD0_HUMAN | Breast cancer metastasis-suppressor... | BRMS1L | 215 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 206 | V → G in AAV83797 (PubMed:15451426).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055547 | 1 – 48 | Missing in isoform 2. 1 PublicationAdd BLAST | 48 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY827074 mRNA Translation: AAV83797.1 AK315424 mRNA Translation: BAG37812.1 AL162311 Genomic DNA No translation available. BC006250 mRNA Translation: AAH06250.2 |
CCDSi | CCDS32066.1 [Q5PSV4-1] |
RefSeqi | NP_115728.2, NM_032352.3 [Q5PSV4-1] XP_006720338.1, XM_006720275.2 [Q5PSV4-2] XP_016877193.1, XM_017021704.1 [Q5PSV4-2] XP_016877194.1, XM_017021705.1 [Q5PSV4-2] |
Genome annotation databases
Ensembli | ENST00000216807.12; ENSP00000216807.6; ENSG00000100916.14 |
GeneIDi | 84312 |
KEGGi | hsa:84312 |
MANE-Selecti | ENST00000216807.12; ENSP00000216807.6; NM_032352.4; NP_115728.2 |
UCSCi | uc001wtl.4, human [Q5PSV4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY827074 mRNA Translation: AAV83797.1 AK315424 mRNA Translation: BAG37812.1 AL162311 Genomic DNA No translation available. BC006250 mRNA Translation: AAH06250.2 |
CCDSi | CCDS32066.1 [Q5PSV4-1] |
RefSeqi | NP_115728.2, NM_032352.3 [Q5PSV4-1] XP_006720338.1, XM_006720275.2 [Q5PSV4-2] XP_016877193.1, XM_017021704.1 [Q5PSV4-2] XP_016877194.1, XM_017021705.1 [Q5PSV4-2] |
3D structure databases
AlphaFoldDBi | Q5PSV4 |
SMRi | Q5PSV4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124038, 97 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q5PSV4 |
IntActi | Q5PSV4, 62 interactors |
MINTi | Q5PSV4 |
STRINGi | 9606.ENSP00000216807 |
PTM databases
GlyGeni | Q5PSV4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q5PSV4 |
PhosphoSitePlusi | Q5PSV4 |
Genetic variation databases
BioMutai | BRMS1L |
DMDMi | 158706476 |
Proteomic databases
EPDi | Q5PSV4 |
jPOSTi | Q5PSV4 |
MassIVEi | Q5PSV4 |
MaxQBi | Q5PSV4 |
PaxDbi | Q5PSV4 |
PeptideAtlasi | Q5PSV4 |
PRIDEi | Q5PSV4 |
ProteomicsDBi | 3426 63603 [Q5PSV4-1] |
Protocols and materials databases
Antibodypediai | 23255, 115 antibodies from 20 providers |
DNASUi | 84312 |
Genome annotation databases
Ensembli | ENST00000216807.12; ENSP00000216807.6; ENSG00000100916.14 |
GeneIDi | 84312 |
KEGGi | hsa:84312 |
MANE-Selecti | ENST00000216807.12; ENSP00000216807.6; NM_032352.4; NP_115728.2 |
UCSCi | uc001wtl.4, human [Q5PSV4-1] |
Organism-specific databases
CTDi | 84312 |
DisGeNETi | 84312 |
GeneCardsi | BRMS1L |
HGNCi | HGNC:20512, BRMS1L |
HPAi | ENSG00000100916, Low tissue specificity |
MIMi | 618514, gene |
neXtProti | NX_Q5PSV4 |
OpenTargetsi | ENSG00000100916 |
PharmGKBi | PA134968356 |
VEuPathDBi | HostDB:ENSG00000100916 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4466, Eukaryota |
GeneTreei | ENSGT00940000158921 |
HOGENOMi | CLU_050862_2_0_1 |
InParanoidi | Q5PSV4 |
OMAi | ICIDRKD |
OrthoDBi | 1456563at2759 |
PhylomeDBi | Q5PSV4 |
TreeFami | TF323740 |
Enzyme and pathway databases
PathwayCommonsi | Q5PSV4 |
SignaLinki | Q5PSV4 |
Miscellaneous databases
BioGRID-ORCSi | 84312, 17 hits in 1080 CRISPR screens |
ChiTaRSi | BRMS1L, human |
GenomeRNAii | 84312 |
Pharosi | Q5PSV4, Tbio |
PROi | PR:Q5PSV4 |
RNActi | Q5PSV4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100916, Expressed in frontal cortex and 217 other tissues |
ExpressionAtlasi | Q5PSV4, baseline and differential |
Genevisiblei | Q5PSV4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013907, Sds3 |
PANTHERi | PTHR21964, PTHR21964, 1 hit |
Pfami | View protein in Pfam PF08598, Sds3, 1 hit |
SMARTi | View protein in SMART SM01401, Sds3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BRM1L_HUMAN | |
Accessioni | Q5PSV4Primary (citable) accession number: Q5PSV4 Secondary accession number(s): A6NFW5 Q9BRI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | May 25, 2022 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families