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UniProtKB - Q5PRF9 (SMAG2_HUMAN)

Entry version 144 (02 Jun 2021)
Sequence version 1 (04 Jan 2005)
Previous versions | rss
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Protein

Protein Smaug homolog 2

Gene

SAMD4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5PRF9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Smaug homolog 2
Short name:
Smaug 2
Short name:
hSmaug2
Alternative name(s):
Sterile alpha motif domain-containing protein 4B
Short name:
SAM domain-containing protein 4B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAMD4B
Synonyms:SMAUG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25492, SAMD4B

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5PRF9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000179134.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55095

Open Targets

More...OpenTargetsi		ENSG00000179134

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485607

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5PRF9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SAMD4B

Domain mapping of disease mutations (DMDM)

More...DMDMi		74736136

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002600801 – 694Protein Smaug homolog 2Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei172PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1
Modified residuei278PhosphoserineBy similarity1
Modified residuei279PhosphoserineBy similarity1
Modified residuei281PhosphoserineBy similarity1
Modified residuei407PhosphothreonineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei557PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei602Asymmetric dimethylarginineCombined sources1
Modified residuei628PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5PRF9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5PRF9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5PRF9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5PRF9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5PRF9

PeptideAtlas

More...PeptideAtlasi		Q5PRF9

PRoteomics IDEntifications database

More...PRIDEi		Q5PRF9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63602

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5PRF9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5PRF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in embryonic and adult tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000179134, Expressed in lower esophagus mucosa and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5PRF9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5PRF9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000179134, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120407, 114 interactors

Protein interaction database and analysis system

More...IntActi		Q5PRF9, 24 interactors

Molecular INTeraction database

More...MINTi		Q5PRF9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000317224

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5PRF9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5PRF9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini299 – 372SAMAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni158 – 301DisorderedSequence analysisAdd BLAST144
Regioni407 – 471DisorderedSequence analysisAdd BLAST65
Regioni607 – 643DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi208 – 226Polar residuesSequence analysisAdd BLAST19
Compositional biasi267 – 299Polar residuesSequence analysisAdd BLAST33
Compositional biasi443 – 460Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMAUG family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3791, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159702

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016365_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5PRF9

Identification of Orthologs from Complete Genome Data

More...OMAi		QFQMPPR

Database of Orthologous Groups

More...OrthoDBi		670335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5PRF9

TreeFam database of animal gene trees

More...TreeFami		TF324165

Family and domain databases

Conserved Domains Database

More...CDDi		cd09557, SAM_Smaug, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR037634, Smaug_SAM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00536, SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q5PRF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFRDQVGIL AGWFKGWNEC EQTVALLSLL KRVTRTQARF LQLCLEHSLA 
        60         70         80         90        100
DCNDIHLLES EANSAAIVSQ WQQESKEKVV SLLLSHLPLL QPGNTEAKSE 
       110        120        130        140        150
YMRLLQKVLA YSIESNAFIE ESRQLLSYAL IHPATTLEDR NALALWLSHL 
       160        170        180        190        200
EERLASGFRS RPEPSYHSRQ GSDEWGGPAE LGPGEAGPGW QDKPPRENGH 
       210        220        230        240        250
VPFHPSSSVP PAINSIGSNA NTGLPCQIHP SPLKRSMSLI PTSPQVPGEW 
       260        270        280        290        300
PSPEELGARA AFTTPDHAPL SPQSSVASSG SEQTEEQGSS RNTFQEDGSG 
       310        320        330        340        350
MKDVPSWLKS LRLHKYAALF SQMSYEEMMT LTEQHLESQN VTKGARHKIA 
       360        370        380        390        400
LSIQKLRERQ SVLKSLEKDV LEGGNLRNAL QELQQIIITP IKAYSVLQAT 
       410        420        430        440        450
VAAATTTPTA KDGAPGEPPL PGAEPPLAHP GTDKGTEAKD PPAVENYPPP 
       460        470        480        490        500
PAPAPTDGSE PAPAPVADGD IPSQFTRVMG KVCTQLLVSR PDEENITSYL 
       510        520        530        540        550
QLIEKCLTHE AFTETQKKRL LSWKQQVLKL LRTFPRKAAL EMQNYRQQKG 
       560        570        580        590        600
WAFGSNSLPI AGSVGMGVAR RTQRQFPMPP RALPPGRMGL LSPSGIGGVS 
       610        620        630        640        650
PRHALTSPSL GGQGRQNLWF ANPGGSNSMP SQSRSSVQRT HSLPVHSSPQ 
       660        670        680        690 
AILMFPPDCP VPGPDLEINP TLESLCLSMT EHALGDGTDK TSTI
Length:694
Mass (Da):75,483
Last modified:January 4, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AA4769F38494E56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZ22M0QZ22_HUMAN
Protein Smaug homolog 2
SAMD4B
692Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZT0A0A087WZT0_HUMAN
Protein Smaug homolog 2
SAMD4B
663Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0X3M0R0X3_HUMAN
Protein Smaug homolog 2
SAMD4B
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY61M0QY61_HUMAN
Protein Smaug homolog 2
SAMD4B
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX45M0QX45_HUMAN
Protein Smaug homolog 2
SAMD4B
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZW7M0QZW7_HUMAN
Protein Smaug homolog 2
SAMD4B
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXV2M0QXV2_HUMAN
Protein Smaug homolog 2
SAMD4B
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EF601121 mRNA Translation: ABQ85549.1
CH471126 Genomic DNA Translation: EAW56877.1
BC054518 mRNA Translation: AAH54518.1
BC065211 mRNA Translation: AAH65211.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33020.1

NCBI Reference Sequences

More...RefSeqi		NP_001290543.1, NM_001303614.1
NP_060498.2, NM_018028.3
XP_011525365.1, XM_011527063.2
XP_016882409.1, XM_017026920.1
XP_016882410.1, XM_017026921.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000314471; ENSP00000317224; ENSG00000179134
ENST00000610417; ENSP00000484229; ENSG00000179134

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55095

UCSC genome browser

More...UCSCi		uc002olb.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF601121 mRNA Translation: ABQ85549.1
CH471126 Genomic DNA Translation: EAW56877.1
BC054518 mRNA Translation: AAH54518.1
BC065211 mRNA Translation: AAH65211.1
CCDSiCCDS33020.1
RefSeqiNP_001290543.1, NM_001303614.1
NP_060498.2, NM_018028.3
XP_011525365.1, XM_011527063.2
XP_016882409.1, XM_017026920.1
XP_016882410.1, XM_017026921.1

3D structure databases

SMRiQ5PRF9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120407, 114 interactors
IntActiQ5PRF9, 24 interactors
MINTiQ5PRF9
STRINGi9606.ENSP00000317224

PTM databases

iPTMnetiQ5PRF9
PhosphoSitePlusiQ5PRF9

Genetic variation databases

BioMutaiSAMD4B
DMDMi74736136

Proteomic databases

EPDiQ5PRF9
jPOSTiQ5PRF9
MassIVEiQ5PRF9
MaxQBiQ5PRF9
PaxDbiQ5PRF9
PeptideAtlasiQ5PRF9
PRIDEiQ5PRF9
ProteomicsDBi63602

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16754, 139 antibodies

The DNASU plasmid repository

More...DNASUi		55095

Genome annotation databases

EnsembliENST00000314471; ENSP00000317224; ENSG00000179134
ENST00000610417; ENSP00000484229; ENSG00000179134
GeneIDi55095
KEGGihsa:55095
UCSCiuc002olb.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55095
DisGeNETi55095

GeneCards: human genes, protein and diseases

More...GeneCardsi		SAMD4B
HGNCiHGNC:25492, SAMD4B
HPAiENSG00000179134, Low tissue specificity
neXtProtiNX_Q5PRF9
OpenTargetsiENSG00000179134
PharmGKBiPA143485607
VEuPathDBiHostDB:ENSG00000179134.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3791, Eukaryota
GeneTreeiENSGT00940000159702
HOGENOMiCLU_016365_0_1_1
InParanoidiQ5PRF9
OMAiQFQMPPR
OrthoDBi670335at2759
PhylomeDBiQ5PRF9
TreeFamiTF324165

Enzyme and pathway databases

PathwayCommonsiQ5PRF9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55095, 165 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SAMD4B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55095
PharosiQ5PRF9, Tbio

Protein Ontology

More...PROi		PR:Q5PRF9
RNActiQ5PRF9, protein

Gene expression databases

BgeeiENSG00000179134, Expressed in lower esophagus mucosa and 214 other tissues
ExpressionAtlasiQ5PRF9, baseline and differential
GenevisibleiQ5PRF9, HS

Family and domain databases

CDDicd09557, SAM_Smaug, 1 hit
Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR037634, Smaug_SAM
PfamiView protein in Pfam
PF00536, SAM_1, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMAG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5PRF9
Secondary accession number(s): A5Z0M6, Q6P194
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 4, 2005
Last modified: June 2, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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