UniProtKB - Q5PRF9 (SMAG2_HUMAN)
Protein
Protein Smaug homolog 2
Gene
SAMD4B
Organism
Homo sapiens (Human)
Status
Functioni
Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.1 Publication
GO - Molecular functioni
- mRNA binding Source: GO_Central
- RNA binding Source: UniProtKB
- translation repressor activity Source: GO_Central
GO - Biological processi
- negative regulation of translation Source: GO_Central
- nuclear-transcribed mRNA poly(A) tail shortening Source: GO_Central
- regulation of mRNA stability Source: GO_Central
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q5PRF9 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Smaug homolog 2Short name: Smaug 2 Short name: hSmaug2 Alternative name(s): Sterile alpha motif domain-containing protein 4B Short name: SAM domain-containing protein 4B |
Gene namesi | Name:SAMD4B Synonyms:SMAUG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25492, SAMD4B |
neXtProti | NX_Q5PRF9 |
VEuPathDBi | HostDB:ENSG00000179134.14 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55095 |
OpenTargetsi | ENSG00000179134 |
PharmGKBi | PA143485607 |
Miscellaneous databases
Pharosi | Q5PRF9, Tbio |
Genetic variation databases
BioMutai | SAMD4B |
DMDMi | 74736136 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000260080 | 1 – 694 | Protein Smaug homolog 2Add BLAST | 694 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 172 | PhosphoserineCombined sources | 1 | |
Modified residuei | 271 | PhosphoserineCombined sources | 1 | |
Modified residuei | 278 | PhosphoserineBy similarity | 1 | |
Modified residuei | 279 | PhosphoserineBy similarity | 1 | |
Modified residuei | 281 | PhosphoserineBy similarity | 1 | |
Modified residuei | 407 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 555 | PhosphoserineCombined sources | 1 | |
Modified residuei | 557 | PhosphoserineCombined sources | 1 | |
Modified residuei | 563 | PhosphoserineCombined sources | 1 | |
Modified residuei | 592 | PhosphoserineCombined sources | 1 | |
Modified residuei | 600 | PhosphoserineCombined sources | 1 | |
Modified residuei | 602 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 628 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q5PRF9 |
jPOSTi | Q5PRF9 |
MassIVEi | Q5PRF9 |
MaxQBi | Q5PRF9 |
PaxDbi | Q5PRF9 |
PeptideAtlasi | Q5PRF9 |
PRIDEi | Q5PRF9 |
ProteomicsDBi | 63602 |
PTM databases
iPTMneti | Q5PRF9 |
PhosphoSitePlusi | Q5PRF9 |
Expressioni
Tissue specificityi
Widely expressed in embryonic and adult tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000179134, Expressed in lower esophagus mucosa and 213 other tissues |
ExpressionAtlasi | Q5PRF9, baseline and differential |
Genevisiblei | Q5PRF9, HS |
Organism-specific databases
HPAi | ENSG00000179134, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ5PRF9
Protein-protein interaction databases
BioGRIDi | 120407, 114 interactors |
IntActi | Q5PRF9, 23 interactors |
MINTi | Q5PRF9 |
STRINGi | 9606.ENSP00000317224 |
Miscellaneous databases
RNActi | Q5PRF9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 299 – 372 | SAMAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the SMAUG family.Curated
Phylogenomic databases
eggNOGi | KOG3791, Eukaryota |
GeneTreei | ENSGT00940000159702 |
HOGENOMi | CLU_016365_0_1_1 |
InParanoidi | Q5PRF9 |
OMAi | QFQMPPR |
OrthoDBi | 670335at2759 |
PhylomeDBi | Q5PRF9 |
TreeFami | TF324165 |
Family and domain databases
CDDi | cd09557, SAM_Smaug, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf IPR037634, Smaug_SAM |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q5PRF9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMFRDQVGIL AGWFKGWNEC EQTVALLSLL KRVTRTQARF LQLCLEHSLA
60 70 80 90 100
DCNDIHLLES EANSAAIVSQ WQQESKEKVV SLLLSHLPLL QPGNTEAKSE
110 120 130 140 150
YMRLLQKVLA YSIESNAFIE ESRQLLSYAL IHPATTLEDR NALALWLSHL
160 170 180 190 200
EERLASGFRS RPEPSYHSRQ GSDEWGGPAE LGPGEAGPGW QDKPPRENGH
210 220 230 240 250
VPFHPSSSVP PAINSIGSNA NTGLPCQIHP SPLKRSMSLI PTSPQVPGEW
260 270 280 290 300
PSPEELGARA AFTTPDHAPL SPQSSVASSG SEQTEEQGSS RNTFQEDGSG
310 320 330 340 350
MKDVPSWLKS LRLHKYAALF SQMSYEEMMT LTEQHLESQN VTKGARHKIA
360 370 380 390 400
LSIQKLRERQ SVLKSLEKDV LEGGNLRNAL QELQQIIITP IKAYSVLQAT
410 420 430 440 450
VAAATTTPTA KDGAPGEPPL PGAEPPLAHP GTDKGTEAKD PPAVENYPPP
460 470 480 490 500
PAPAPTDGSE PAPAPVADGD IPSQFTRVMG KVCTQLLVSR PDEENITSYL
510 520 530 540 550
QLIEKCLTHE AFTETQKKRL LSWKQQVLKL LRTFPRKAAL EMQNYRQQKG
560 570 580 590 600
WAFGSNSLPI AGSVGMGVAR RTQRQFPMPP RALPPGRMGL LSPSGIGGVS
610 620 630 640 650
PRHALTSPSL GGQGRQNLWF ANPGGSNSMP SQSRSSVQRT HSLPVHSSPQ
660 670 680 690
AILMFPPDCP VPGPDLEINP TLESLCLSMT EHALGDGTDK TSTI
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZ22 | M0QZ22_HUMAN | Protein Smaug homolog 2 | SAMD4B | 692 | Annotation score: | ||
A0A087WZT0 | A0A087WZT0_HUMAN | Protein Smaug homolog 2 | SAMD4B | 663 | Annotation score: | ||
M0R0X3 | M0R0X3_HUMAN | Protein Smaug homolog 2 | SAMD4B | 325 | Annotation score: | ||
M0QY61 | M0QY61_HUMAN | Protein Smaug homolog 2 | SAMD4B | 219 | Annotation score: | ||
M0QX45 | M0QX45_HUMAN | Protein Smaug homolog 2 | SAMD4B | 94 | Annotation score: | ||
M0QZW7 | M0QZW7_HUMAN | Protein Smaug homolog 2 | SAMD4B | 48 | Annotation score: | ||
M0QXV2 | M0QXV2_HUMAN | Protein Smaug homolog 2 | SAMD4B | 75 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF601121 mRNA Translation: ABQ85549.1 CH471126 Genomic DNA Translation: EAW56877.1 BC054518 mRNA Translation: AAH54518.1 BC065211 mRNA Translation: AAH65211.1 |
CCDSi | CCDS33020.1 |
RefSeqi | NP_001290543.1, NM_001303614.1 NP_060498.2, NM_018028.3 XP_011525365.1, XM_011527063.2 XP_016882409.1, XM_017026920.1 XP_016882410.1, XM_017026921.1 |
Genome annotation databases
Ensembli | ENST00000314471; ENSP00000317224; ENSG00000179134 ENST00000610417; ENSP00000484229; ENSG00000179134 |
GeneIDi | 55095 |
KEGGi | hsa:55095 |
UCSCi | uc002olb.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF601121 mRNA Translation: ABQ85549.1 CH471126 Genomic DNA Translation: EAW56877.1 BC054518 mRNA Translation: AAH54518.1 BC065211 mRNA Translation: AAH65211.1 |
CCDSi | CCDS33020.1 |
RefSeqi | NP_001290543.1, NM_001303614.1 NP_060498.2, NM_018028.3 XP_011525365.1, XM_011527063.2 XP_016882409.1, XM_017026920.1 XP_016882410.1, XM_017026921.1 |
3D structure databases
SMRi | Q5PRF9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120407, 114 interactors |
IntActi | Q5PRF9, 23 interactors |
MINTi | Q5PRF9 |
STRINGi | 9606.ENSP00000317224 |
PTM databases
iPTMneti | Q5PRF9 |
PhosphoSitePlusi | Q5PRF9 |
Genetic variation databases
BioMutai | SAMD4B |
DMDMi | 74736136 |
Proteomic databases
EPDi | Q5PRF9 |
jPOSTi | Q5PRF9 |
MassIVEi | Q5PRF9 |
MaxQBi | Q5PRF9 |
PaxDbi | Q5PRF9 |
PeptideAtlasi | Q5PRF9 |
PRIDEi | Q5PRF9 |
ProteomicsDBi | 63602 |
Protocols and materials databases
Antibodypediai | 16754, 139 antibodies |
Genome annotation databases
Ensembli | ENST00000314471; ENSP00000317224; ENSG00000179134 ENST00000610417; ENSP00000484229; ENSG00000179134 |
GeneIDi | 55095 |
KEGGi | hsa:55095 |
UCSCi | uc002olb.4, human |
Organism-specific databases
CTDi | 55095 |
DisGeNETi | 55095 |
GeneCardsi | SAMD4B |
HGNCi | HGNC:25492, SAMD4B |
HPAi | ENSG00000179134, Low tissue specificity |
neXtProti | NX_Q5PRF9 |
OpenTargetsi | ENSG00000179134 |
PharmGKBi | PA143485607 |
VEuPathDBi | HostDB:ENSG00000179134.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3791, Eukaryota |
GeneTreei | ENSGT00940000159702 |
HOGENOMi | CLU_016365_0_1_1 |
InParanoidi | Q5PRF9 |
OMAi | QFQMPPR |
OrthoDBi | 670335at2759 |
PhylomeDBi | Q5PRF9 |
TreeFami | TF324165 |
Enzyme and pathway databases
PathwayCommonsi | Q5PRF9 |
Miscellaneous databases
BioGRID-ORCSi | 55095, 165 hits in 1003 CRISPR screens |
ChiTaRSi | SAMD4B, human |
GenomeRNAii | 55095 |
Pharosi | Q5PRF9, Tbio |
PROi | PR:Q5PRF9 |
RNActi | Q5PRF9, protein |
Gene expression databases
Bgeei | ENSG00000179134, Expressed in lower esophagus mucosa and 213 other tissues |
ExpressionAtlasi | Q5PRF9, baseline and differential |
Genevisiblei | Q5PRF9, HS |
Family and domain databases
CDDi | cd09557, SAM_Smaug, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf IPR037634, Smaug_SAM |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMAG2_HUMAN | |
Accessioni | Q5PRF9Primary (citable) accession number: Q5PRF9 Secondary accession number(s): A5Z0M6, Q6P194 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | January 4, 2005 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families