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Entry version 126 (29 Sep 2021)
Sequence version 1 (04 Jan 2005)
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Protein
Submitted name:

Ncor1 protein

Gene

Ncor1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ncor1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncor1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1349717, Ncor1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5PRE9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5PRE9, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini436 – 487SANTInterPro annotationAdd BLAST52
Domaini620 – 674HTH myb-typeInterPro annotationAdd BLAST55
Domaini620 – 670Myb-likeInterPro annotationAdd BLAST51
Domaini623 – 674SANTInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 117DisorderedSequence analysisAdd BLAST117
Regioni139 – 178DisorderedSequence analysisAdd BLAST40
Regioni207 – 232DisorderedSequence analysisAdd BLAST26
Regioni498 – 630DisorderedSequence analysisAdd BLAST133
Regioni680 – 878DisorderedSequence analysisAdd BLAST199
Regioni985 – 1009DisorderedSequence analysisAdd BLAST25
Regioni1383 – 1478DisorderedSequence analysisAdd BLAST96
Regioni1631 – 1714DisorderedSequence analysisAdd BLAST84
Regioni1836 – 1874DisorderedSequence analysisAdd BLAST39
Regioni1893 – 1993DisorderedSequence analysisAdd BLAST101
Regioni2019 – 2108DisorderedSequence analysisAdd BLAST90
Regioni2237 – 2330DisorderedSequence analysisAdd BLAST94
Regioni2359 – 2387DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili309 – 329Sequence analysisAdd BLAST21
Coiled coili1806 – 1826Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 39Polar residuesSequence analysisAdd BLAST39
Compositional biasi47 – 70Polar residuesSequence analysisAdd BLAST24
Compositional biasi101 – 116Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi164 – 178Polar residuesSequence analysisAdd BLAST15
Compositional biasi505 – 571Basic and acidic residuesSequence analysisAdd BLAST67
Compositional biasi605 – 620Pro residuesSequence analysisAdd BLAST16
Compositional biasi801 – 839Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi1424 – 1469Polar residuesSequence analysisAdd BLAST46
Compositional biasi1649 – 1682Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi1857 – 1873Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1903 – 1917Polar residuesSequence analysisAdd BLAST15
Compositional biasi1947 – 1975Polar residuesSequence analysisAdd BLAST29
Compositional biasi2019 – 2061Polar residuesSequence analysisAdd BLAST43
Compositional biasi2076 – 2090Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2278 – 2308Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the N-CoR nuclear receptor corepressors family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
12227at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167, SANT, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017930, Myb_dom
IPR031557, N-CoR_GPS2_interact
IPR001005, SANT/Myb
IPR017884, SANT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15784, GPS2_interact, 1 hit
PF00249, Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717, SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51294, HTH_MYB, 1 hit
PS50090, MYB_LIKE, 1 hit
PS51293, SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5PRE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSGYPPNQ GAFSTEQSRY PSHSVQYTFP STRHQQEFAV PDYRSSHIEV
60 70 80 90 100
SQASQLLQQQ QQQQQLRRRP SLLSEFHPGS DRPQERRTGY EQFHSGPSPV
110 120 130 140 150
DHDSLESKRP RLEPVSDAHF QRVSAAVLPL VHSLPEGLRS SADAKKDSAF
160 170 180 190 200
GSKHEAPSSP LAGQPCGDDQ NASPSKLSKE ELIQSMDRVD REIAKVEQQI
210 220 230 240 250
LKLKKKQQQL EEEAAKPPEP EKPVSPPPVE QKHRSIVQII YDENRKKAEE
260 270 280 290 300
AHKIFEGLGP KVELPLYNQP SDTKVYHENI KTNQVMRKKL ILFFKRRNHA
310 320 330 340 350
RKQREQKICQ RYDQLMEAWE KKVDRIENNP RRKAKESKTR EYYEKQFPEI
360 370 380 390 400
RKQREQQERF QRVGQRGAGL SATIARSEHE ISEIIDGLSE QENNEKQMRQ
410 420 430 440 450
LSVIPPMMFD AEQRRVKFIN MNGLMEDPMK VYKDRQFMNV WTDHEKEIFK
460 470 480 490 500
DKFIQHPKNF GLIASYLERK SVPDCVLYYY LTKKNENYKA LVRRNYGKRR
510 520 530 540 550
GRNQQIARPS QEEKVEEKEE DKAEKTEKKE EEKKDDEEKD DKEDSKETTK
560 570 580 590 600
EKDRTEATAE EPEEREQVTP RGRKTANSQG RRKGRVTRSM TSEAAAANAA
610 620 630 640 650
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI
660 670 680 690 700
AKMVGTKSEA QCKNFYFNYK RRHNLDNLLQ QHKQKVSRAV VASRKPREER
710 720 730 740 750
DVSQCESVAS TVSAQEDEDI EASNEEENPE DSEAVPTTKP AERESVEAQV
760 770 780 790 800
TDSASAETAE PMDVDHEECG AEGSSVLDPP APTKADSVDP EMQVPENTAS
810 820 830 840 850
KGEGDAKERD LESTSEKTEA RDEDVVVAEQ IERPEPQSDD DSSATCSADE
860 870 880 890 900
GVDGEPERQR VFPMDAKPSL LTPPGSILIS SPIKPNPLDL PQLQHRAAVI
910 920 930 940 950
PPMVSCTPCN IPIGTPVSGY ALYQRHIKAM HESALLEEQR QRQEQVDLEC
960 970 980 990 1000
RSSTSPCSTS KSPNREWEVL QPAPHQVITN LPEGVRLPTT RPTRPPPPLI
1010 1020 1030 1040 1050
PSSKTTVASE KPSFIMGGSI SQGTPGTYLS SHNQAYPQEA PKPSVGSISL
1060 1070 1080 1090 1100
GLPRQQESTK AAPLTYIKQE EFSPRSQNSQ PEGLLVRAQH EGTAGAVQEG
1110 1120 1130 1140 1150
SITRGTPASK ISVETISSLR GSITQGTPAL PQAGIPTEAL VKGPVSRMPI
1160 1170 1180 1190 1200
EESSPEKVRE EAASKGHVIY EGKSGHILSY DNIKNAREGT RSPRTAHEMS
1210 1220 1230 1240 1250
LKRSYEAVEG SIKQGLICRA LPRGSPHSDL KERTVLSGSI MQGTPRATAE
1260 1270 1280 1290 1300
SFEDGLKYPK QIKRESPPIR AFEGAITKGK PYDGITTIKE MGRSIHEIPR
1310 1320 1330 1340 1350
QDILTQESRK TPEVVQSTRP IIEGSISQGT PIKFDNNSGQ SAIKHNVKSL
1360 1370 1380 1390 1400
ITGPSKLPRG MLEIVPENIK VVERGKYEDV KAGEPVRARH TSVVSSGPSV
1410 1420 1430 1440 1450
LRSTLHEAPK AQLSPGLYDD SSARRTPVSY QNTISRGSPM MNRTSDVSSS
1460 1470 1480 1490 1500
KSASHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH HRSSAAGEVY
1510 1520 1530 1540 1550
RSHLPTHLDP AMPFHRALDP AAAAYLLQRQ LSPTPGYPSQ YQLYAMENTR
1560 1570 1580 1590 1600
QTILNDYITS QQMQVNLRPD VTRGLSPREQ PLGLPYPATR GIIDLTNMPP
1610 1620 1630 1640 1650
TILVPHAGGT STPPMDRITY IPGTQVTFPP RPYNAASLSP GHPTHLAAAA
1660 1670 1680 1690 1700
SAERERERER EKERERERER ERERERERIA AAPADLYLRP GSEQPGRPGS
1710 1720 1730 1740 1750
HGYVRSPSPS VRTQETILQQ RPSVFQGTNG TSVITPLDPT AQLRIMPLPS
1760 1770 1780 1790 1800
GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE
1810 1820 1830 1840 1850
ENLRSRSAAV SEQQQLEQKN LEVEKRSVQC VCTSSALPSG KAQPHASVVY
1860 1870 1880 1890 1900
SEAGKDKGPP PKSRYEEELR TRGKTTITAA NFIDVIITRQ IASDKDARER
1910 1920 1930 1940 1950
GSQSSDSSSS LSSHRYETAS DAIEVISPAS SPAPPQEKPQ AYQPDMVKAN
1960 1970 1980 1990 2000
QAENESTRQY EGPLHHYRSQ QESPSPQQQP PLPPSSQSEG MGQVPRTHRL
2010 2020 2030 2040 2050
ITLADHICQI ITQDFARNQV PSQPSTSTFQ TSPSALSSTP VRTKTSSRYS
2060 2070 2080 2090 2100
PESQSQTVLH PRPGPRVSPE NLVDKSRGSR PGKSPERSHI PSEPYEPISP
2110 2120 2130 2140 2150
PQGPAVHEKQ DSMLLLSQRG VDPAEQRSDS RSPGSISYLP SFFTKLESTS
2160 2170 2180 2190 2200
PMVKSKKQEI FRKLNSSGGG DSDMAAAQPG TEIFNLPAVT TSGAVSSRSH
2210 2220 2230 2240 2250
SFADPASNLG LEDIIRKALM GSFDDKVEDH GVVMSHPVGI MPGSASTSVV
2260 2270 2280 2290 2300
TSSEARRDEG EPSPHAGVCK PKLINKSNSR KSKSPIPGQS YLGTERPSSV
2310 2320 2330 2340 2350
SSVHSEGDYH RQTPGWAWED RPSSTGSTQF PYNPLTIRML SSTPPTQIAC
2360 2370 2380
APSAITQAAP HQQNRIWERE PAPLLSAQYE TLSDSDD
Length:2,387
Mass (Da):264,125
Last modified:January 4, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70C0E85EEBB5E63F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC086657 mRNA Translation: AAH86657.1

NCBI Reference Sequences

More...
RefSeqi
NP_035438.3, NM_011308.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20185

UCSC genome browser

More...
UCSCi
uc007jix.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086657 mRNA Translation: AAH86657.1
RefSeqiNP_035438.3, NM_011308.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ5PRE9

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
20185

Genome annotation databases

GeneIDi20185
UCSCiuc007jix.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9611
MGIiMGI:1349717, Ncor1

Phylogenomic databases

OrthoDBi12227at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
20185, 4 hits in 67 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ncor1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ5PRE9, MM

Family and domain databases

CDDicd00167, SANT, 2 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017930, Myb_dom
IPR031557, N-CoR_GPS2_interact
IPR001005, SANT/Myb
IPR017884, SANT_dom
PfamiView protein in Pfam
PF15784, GPS2_interact, 1 hit
PF00249, Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717, SANT, 2 hits
SUPFAMiSSF46689, SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51294, HTH_MYB, 1 hit
PS50090, MYB_LIKE, 1 hit
PS51293, SANT, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5PRE9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5PRE9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: September 29, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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