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Entry version 110 (26 Feb 2020)
Sequence version 1 (04 Jan 2005)
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Protein

Zinc transporter 9

Gene

slc30a9

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a zinc transporter involved in intracellular zinc homeostasis. May play a role as nuclear receptor coactivator.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transcription, Transcription regulation, Transport, Zinc transport
LigandZinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc transporter 9
Short name:
ZnT-9
Alternative name(s):
Solute carrier family 30 member 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:slc30a9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040724-254 slc30a9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002958081 – 573Zinc transporter 9Add BLAST573

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5PQZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000057272 Expressed in retina and 27 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5PQZ3 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000074317

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5PQZ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2802 Eukaryota
COG0053 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008346

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021126_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5PQZ3

KEGG Orthology (KO)

More...
KOi
K14696

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVAGACM

Database of Orthologous Groups

More...
OrthoDBi
667718at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5PQZ3

TreeFam database of animal gene trees

More...
TreeFami
TF314526

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1510.10, 1 hit
3.90.530.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
IPR009061 DNA-bd_dom_put_sf
IPR040177 SLC30A9
IPR037129 XPA_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13414 PTHR13414, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01545 Cation_efflux, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161111 SSF161111, 1 hit
SSF46955 SSF46955, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01297 CDF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5PQZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPCLAHRPW QVLCRVYLQQ RAPLSQRSSK ISKPCFGWQS RGGVHKLWFS
60 70 80 90 100
FPDFRVTSLT WTQVQNCSTS GSGKDGSPTR PEEPKTTEKA QAAQPAAKGA
110 120 130 140 150
GSKPQGLTKA ESIQVKVRAV LKKREYGLKY TQNNFITAVR AMNEFCLKPS
160 170 180 190 200
DLEHLRKIRR RSPHDDTEAF TVFLRSDVEA KALEVWGSQE ALARERDQRK
210 220 230 240 250
EVEREYQENI FRNQKLLKEY KDFWGNTKPR SRKRATFLQG PGKVVMVAIC
260 270 280 290 300
INGLNFFFKL LAWVYTGSAS MFSEAIHSLA DTCNQALLAL GISQSVRNPD
310 320 330 340 350
AIHPYGFSNM RYIASLISGV GIFMMGAGLS WYHGIMGLLH PQPIESLLWA
360 370 380 390 400
YCILAGSLVS EGATLLVAIN EIKKSARTQG LSFYEYVMQS RDPSTNVVLL
410 420 430 440 450
EDAAAVLGVV LAAGCMGLTS LTGNPYYDSL GSLGVGTLLG TVSAFLIYTN
460 470 480 490 500
TEALLGRSIQ AEHMQKLTEF LENDPAVRAI HDVKATDMGL SKVRFKAEVD
510 520 530 540 550
FDGRVVTRSY LEKQDIEQIL NEIQQVKTPE ELENFMLKHG ENIIDTLGAE
560 570
VDRLEKELKQ RNPEVRHVDL EIL
Length:573
Mass (Da):64,178
Last modified:January 4, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FFAC56B39D76068
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QJE8F1QJE8_DANRE
Zinc transporter 9
slc30a9
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LFU8A0A140LFU8_DANRE
Zinc transporter 9
slc30a9
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAE30408 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL808108 Genomic DNA Translation: CAE30408.1 Sequence problems.
BC086961 mRNA Translation: AAH86961.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008575.1, NM_001008575.1
XP_005173391.1, XM_005173334.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000079866; ENSDARP00000074317; ENSDARG00000057272
ENSDART00000180361; ENSDARP00000148224; ENSDARG00000057272

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
497184

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:497184

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808108 Genomic DNA Translation: CAE30408.1 Sequence problems.
BC086961 mRNA Translation: AAH86961.1
RefSeqiNP_001008575.1, NM_001008575.1
XP_005173391.1, XM_005173334.3

3D structure databases

SMRiQ5PQZ3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000074317

Proteomic databases

PaxDbiQ5PQZ3

Genome annotation databases

EnsembliENSDART00000079866; ENSDARP00000074317; ENSDARG00000057272
ENSDART00000180361; ENSDARP00000148224; ENSDARG00000057272
GeneIDi497184
KEGGidre:497184

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10463
ZFINiZDB-GENE-040724-254 slc30a9

Phylogenomic databases

eggNOGiKOG2802 Eukaryota
COG0053 LUCA
GeneTreeiENSGT00390000008346
HOGENOMiCLU_021126_3_0_1
InParanoidiQ5PQZ3
KOiK14696
OMAiMVAGACM
OrthoDBi667718at2759
PhylomeDBiQ5PQZ3
TreeFamiTF314526

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5PQZ3

Gene expression databases

BgeeiENSDARG00000057272 Expressed in retina and 27 other tissues
ExpressionAtlasiQ5PQZ3 baseline

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
3.90.530.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
IPR009061 DNA-bd_dom_put_sf
IPR040177 SLC30A9
IPR037129 XPA_sf
PANTHERiPTHR13414 PTHR13414, 1 hit
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit
SSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNT9_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5PQZ3
Secondary accession number(s): Q7SZY6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: January 4, 2005
Last modified: February 26, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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