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Protein

Integrin beta-like protein 1

Gene

Itgbl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • integrin binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-like protein 1
Gene namesi
Name:Itgbl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1560635 Itgbl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000032302424 – 494Integrin beta-like protein 1Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5PQQ8
PRIDEiQ5PQQ8

Expressioni

Gene expression databases

BgeeiENSRNOG00000004516 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiQ5PQQ8 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006264

Structurei

3D structure databases

ProteinModelPortaliQ5PQQ8
SMRiQ5PQQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 95IAdd BLAST45
Repeati96 – 142IIAdd BLAST47
Repeati143 – 184IIIAdd BLAST42
Repeati185 – 230IVAdd BLAST46
Repeati231 – 275VAdd BLAST45
Repeati276 – 326VIAdd BLAST51
Repeati327 – 367VIIAdd BLAST41
Repeati368 – 414VIIIAdd BLAST47
Repeati415 – 454IXAdd BLAST40
Repeati455 – 494XAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 494Cysteine-rich tandem repeatsAdd BLAST444

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 476Cys-richAdd BLAST414

Domaini

Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000113115
HOVERGENiHBG052797
InParanoidiQ5PQQ8
OMAiCQYPTHC
OrthoDBiEOG091G05SQ
PhylomeDBiQ5PQQ8
TreeFamiTF332636

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR027070 Integrin_b-like_p1
IPR015812 Integrin_bsu
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF3 PTHR10082:SF3, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS00243 INTEGRIN_BETA, 9 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPPGFKNFL LLVSSLFFIG LSAAPQSFSP SLRSLSGAPC RLSRAESERR
60 70 80 90 100
CRAPGQPPGS ALCHDRGRCE CGVCICHVTE PGTYFGPLCE CHDWVCETYD
110 120 130 140 150
GKTCAGHGTC DCGKCKCDVG WSGEACQYPT KCDLTKKISN QMCKNSQDVI
160 170 180 190 200
CSNAGTCHCG RCKCDNSDGH GLIYGKFCEC DDRECIDDET EEICGGHGKC
210 220 230 240 250
YCGNCYCEAG WHGDKCEFQC DITPWESKRR CTSPDGKVCS NRGTCVCGEC
260 270 280 290 300
SCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
310 320 330 340 350
CRAGWYGKKC EHPKNCPLSA EESTRKCQGS SDLPCSGRGR CECGRCTCYP
360 370 380 390 400
PGDSRVYGKT CECDDRRCED LDGVVCGGRG TCSCGRCVCE KGWFGKLCQH
410 420 430 440 450
PRKCNMTEEQ SRSLCESADG TLCSGKGSCH CGKCICSGEE WYISGEFCDC
460 470 480 490
DDRDCDKHDG LICTGNGICS CGNCECWDGW NGNACEIWLG TEYP
Length:494
Mass (Da):53,904
Last modified:January 4, 2005 - v1
Checksum:i8A60A8CA4FADD366
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087076 mRNA Translation: AAH87076.1
RefSeqiNP_001017505.1, NM_001017505.1
UniGeneiRn.12893

Genome annotation databases

EnsembliENSRNOT00000006264; ENSRNOP00000006264; ENSRNOG00000004516
GeneIDi498564
KEGGirno:498564
UCSCiRGD:1560635 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087076 mRNA Translation: AAH87076.1
RefSeqiNP_001017505.1, NM_001017505.1
UniGeneiRn.12893

3D structure databases

ProteinModelPortaliQ5PQQ8
SMRiQ5PQQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006264

Proteomic databases

PaxDbiQ5PQQ8
PRIDEiQ5PQQ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006264; ENSRNOP00000006264; ENSRNOG00000004516
GeneIDi498564
KEGGirno:498564
UCSCiRGD:1560635 rat

Organism-specific databases

CTDi9358
RGDi1560635 Itgbl1

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064
HOGENOMiHOG000113115
HOVERGENiHBG052797
InParanoidiQ5PQQ8
OMAiCQYPTHC
OrthoDBiEOG091G05SQ
PhylomeDBiQ5PQQ8
TreeFamiTF332636

Miscellaneous databases

PROiPR:Q5PQQ8

Gene expression databases

BgeeiENSRNOG00000004516 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiQ5PQQ8 RN

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR027070 Integrin_b-like_p1
IPR015812 Integrin_bsu
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF3 PTHR10082:SF3, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS00243 INTEGRIN_BETA, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiITGBL_RAT
AccessioniPrimary (citable) accession number: Q5PQQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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