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Protein

LIM and senescent cell antigen-like-containing domain protein

Gene

Lims2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and senescent cell antigen-like-containing domain proteinUniRule annotation
Gene namesi
Name:Lims2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1305273 Lims2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junctionUniRule annotation, Cell membraneUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000016021

Interactioni

Subunit structurei

Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057770

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 69LIM zinc-bindingInterPro annotationAdd BLAST62
Domaini71 – 128LIM zinc-bindingInterPro annotationAdd BLAST58
Domaini133 – 190LIM zinc-bindingInterPro annotationAdd BLAST58
Domaini191 – 250LIM zinc-bindingInterPro annotationAdd BLAST60

Keywords - Domaini

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000253950
HOVERGENiHBG000053

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q5PQM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSECLADAMC QRCQARFAPT ERIVNSNGEL YHEHCFVCAQ CFRPFPEGLF
60 70 80 90 100
YEFEGRKYCE HDFQMLFAPC CGFCGEFVIG RVIKAMNANW HPGCFRCELC
110 120 130 140 150
DVELADLGFV KNAGRHLCRP CHNREKAKGL GKFICQRCHL AIDEQPLMFK
160 170 180 190 200
NDPYHPDHFS CSHCGKELTS DARELKGELY CLPCHDKMGI PICGACRRPI
210 220 230 240 250
EGRVVNALGK QWHVEHFVCA KCEKPFLGHR HYEKKGLAYC ETHYNQLFGD
260 270 280 290 300
VCYNCSHVIE GDGEASVPKP LPPLLSPNQS VLLVVGGAGG VGGGLGDVGE

WRNCGW
Length:306
Mass (Da):34,342
Last modified:January 4, 2005 - v1
Checksum:iE965AFD6EF6345A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07031670 Genomic DNA No translation available.
AABR07072576 Genomic DNA No translation available.
AC112062 Genomic DNA No translation available.
BC087108 mRNA Translation: AAH87108.1
RefSeqiNP_001012163.1, NM_001012163.1
UniGeneiRn.115282

Genome annotation databases

EnsembliENSRNOT00000061054; ENSRNOP00000057770; ENSRNOG00000016021
GeneIDi361303
KEGGirno:361303
UCSCiRGD:1305273 rat

Similar proteinsi

Entry informationi

Entry nameiQ5PQM7_RAT
AccessioniPrimary (citable) accession number: Q5PQM7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: July 18, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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