UniProtKB - Q5PQJ5 (RHG29_RAT)
Rho GTPase-activating protein 29
Arhgap29
Functioni
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity).
In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 609 – 654 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 46 |
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- PDZ domain binding Source: RGD
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-8980692, RHOA GTPase cycle R-RNO-9013148, CDC42 GTPase cycle R-RNO-9013149, RAC1 GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 29Alternative name(s): Rho-type GTPase-activating protein 29 |
Gene namesi | Name:Arhgap29 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306185, Arhgap29 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317584 | 1 – 1266 | Rho GTPase-activating protein 29Add BLAST | 1266 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 166 | PhosphoserineCombined sources | 1 | |
Modified residuei | 171 | PhosphoserineCombined sources | 1 | |
Modified residuei | 174 | PhosphoserineCombined sources | 1 | |
Modified residuei | 185 | PhosphoserineCombined sources | 1 | |
Modified residuei | 496 | PhosphoserineBy similarity | 1 | |
Modified residuei | 516 | PhosphoserineBy similarity | 1 | |
Modified residuei | 549 | PhosphoserineCombined sources | 1 | |
Modified residuei | 915 | PhosphoserineCombined sources | 1 | |
Modified residuei | 951 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1023 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1149 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1151 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q5PQJ5 |
PRIDEi | Q5PQJ5 |
PTM databases
iPTMneti | Q5PQJ5 |
PhosphoSitePlusi | Q5PQJ5 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000012563, Expressed in lung and 21 other tissues |
ExpressionAtlasi | Q5PQJ5, baseline and differential |
Interactioni
Subunit structurei
Interacts with PTPN13/PTPL1.
Interacts with RAP2A via its coiled coil domain (By similarity).
Interacts with RASIP1 (By similarity).
By similarityGO - Molecular functioni
- PDZ domain binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 259768, 1 interactor |
STRINGi | 10116.ENSRNOP00000017076 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 187 – 457 | F-BARPROSITE-ProRule annotationAdd BLAST | 271 | |
Domaini | 668 – 883 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 216 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 538 – 596 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 1033 – 1054 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1114 – 1153 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 1222 – 1248 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1263 – 1266 | Interaction with PTPN13/PTPL1By similarity | 4 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 291 – 413 | Sequence analysisAdd BLAST | 123 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 538 – 554 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1036 – 1051 | Polar residuesSequence analysisAdd BLAST | 16 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 609 – 654 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 46 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1453, Eukaryota |
GeneTreei | ENSGT00950000183110 |
InParanoidi | Q5PQJ5 |
PhylomeDBi | Q5PQJ5 |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR002219, PE/DAG-bd IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS50238, RHOGAP, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIAHKQKKAK KKRVWASGQL SAAITTSEMG LKSVSSNSIF DPEYIKELVN
60 70 80 90 100
DIRKFSHVLL YLKEAILSDC FKEVIHIRLD ELLHMSKHQN LNSVDLQNAA
110 120 130 140 150
ETLASKVKAV NFTEVNDENK NDLFREVFSS IETLAFTFGN ILTNFLMGDV
160 170 180 190 200
GNDSILRLPI SRESKSFENI SMDSVDLPHE KGNFSPIELD NLLLKNSDSI
210 220 230 240 250
ELALSYAKTW SKYTKNIVSW VEKKLNLELE STRNIVKLAE ATRSSIGIQE
260 270 280 290 300
FMPLQSLFTN ALLNDIHSSH LLQQTIAALQ ANKFVQPLLG RKNEMEKQRK
310 320 330 340 350
EIKELWKQQQ NKLLETETAL KKAKLLCMQR QDEYEKAKSS MFRAEEEQLS
360 370 380 390 400
SSVGLGKNLN KLLEKRRRLE EEALQKVEEA NEHYKVCVTN VEERRNDLEN
410 420 430 440 450
TKREILTQLR TLVFQCDLTL KAVTVNLFHM QQLQAASLAN SLQSLCDSAK
460 470 480 490 500
LYDPGQEYSE FVKATSSSEL EEKVDGNVNK QIASSPQTSG YEPADSLEDV
510 520 530 540 550
ARLPDSCHKL EEDRCSNSAD MTGPSFIRSW KFGMFSDSES TGGSSESRSL
560 570 580 590 600
DSESISPGDF HRKLPRTPSS GTMSSADDLD EREPPSPSEA GPNSLGTFKK
610 620 630 640 650
TLMSKAALTH KFRKLRSPTK CRDCEGIVMF PGVECEECLL VCHRKCLENL
660 670 680 690 700
VIVCGHQKLQ GKMHIFGAEF IQVAKKEPDG IPFVLKICAS EIESRALCLQ
710 720 730 740 750
GIYRVCGNKI KTEKLCQALE NGMHLVDISE FSSHDICDVL KLYLRQLPEP
760 770 780 790 800
FILFRLYKEF IDLAKEIQHV NEEQEAKKDS PEDKKHPHVS IEINRILLRS
810 820 830 840 850
KDLLRQLPAS NFNSLHYLIV HLKRVVDHAE ENKMNSKNLG VIFGPTLIRP
860 870 880 890 900
RPTTAPVTIS SLAEYSSQAR VVEFLITYAQ KIFDGSLQPQ AGVIANTGAI
910 920 930 940 950
APQVDHGCHP KPLLSPDERD SDHSLKQLFF SSKEDIRTMD CESKTFELTT
960 970 980 990 1000
SFEESERKQN ALGKCDAPIL DNKVHLLFDQ ELESASHKTE DTCKSPKLLL
1010 1020 1030 1040 1050
LRSDRVANSV QRPTPRTRLR PVSLPVDRLL LLAGSPTERS SRNTGNTDSD
1060 1070 1080 1090 1100
KFGKNAAFEG LHRKDNSNTT CSKVNGFDQQ NVQKSWDKQN ERNSFTAKTT
1110 1120 1130 1140 1150
VIIPSAYAEK GLAVSTGNNR GHSSGAAQPS KAHADPARSA RDTSEHSSSD
1160 1170 1180 1190 1200
SCPVAAVRAP RTLQPQHWTT FYKPPNPTFN VRGTEEKTAF PSAAVPPVLV
1210 1220 1230 1240 1250
HAPQSHVAKS DPDLEATLAC PVQTSGQPKE SSEEPGLPEG TPTCQRPRLK
1260
RMQQFEDLED EIPQFV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1LPZ1 | F1LPZ1_RAT | Rho GTPase-activating protein 29 | Arhgap29 rCG_28970 | 1,271 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031061 | 1 – 84 | Missing in isoform 2. 1 PublicationAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03012575 Genomic DNA No translation available. BC087167 mRNA Translation: AAH87167.1 |
RefSeqi | NP_001009405.1, NM_001009405.1 [Q5PQJ5-2] |
Genome annotation databases
Ensembli | ENSRNOT00000066486; ENSRNOP00000062636; ENSRNOG00000012563 [Q5PQJ5-2] |
GeneIDi | 310833 |
KEGGi | rno:310833 |
UCSCi | RGD:1306185, rat [Q5PQJ5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03012575 Genomic DNA No translation available. BC087167 mRNA Translation: AAH87167.1 |
RefSeqi | NP_001009405.1, NM_001009405.1 [Q5PQJ5-2] |
3D structure databases
SMRi | Q5PQJ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 259768, 1 interactor |
STRINGi | 10116.ENSRNOP00000017076 |
PTM databases
iPTMneti | Q5PQJ5 |
PhosphoSitePlusi | Q5PQJ5 |
Proteomic databases
PaxDbi | Q5PQJ5 |
PRIDEi | Q5PQJ5 |
Genome annotation databases
Ensembli | ENSRNOT00000066486; ENSRNOP00000062636; ENSRNOG00000012563 [Q5PQJ5-2] |
GeneIDi | 310833 |
KEGGi | rno:310833 |
UCSCi | RGD:1306185, rat [Q5PQJ5-1] |
Organism-specific databases
CTDi | 9411 |
RGDi | 1306185, Arhgap29 |
Phylogenomic databases
eggNOGi | KOG1453, Eukaryota |
GeneTreei | ENSGT00950000183110 |
InParanoidi | Q5PQJ5 |
PhylomeDBi | Q5PQJ5 |
Enzyme and pathway databases
Reactomei | R-RNO-8980692, RHOA GTPase cycle R-RNO-9013148, CDC42 GTPase cycle R-RNO-9013149, RAC1 GTPase cycle |
Miscellaneous databases
PROi | PR:Q5PQJ5 |
Gene expression databases
Bgeei | ENSRNOG00000012563, Expressed in lung and 21 other tissues |
ExpressionAtlasi | Q5PQJ5, baseline and differential |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR002219, PE/DAG-bd IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS50238, RHOGAP, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG29_RAT | |
Accessioni | Q5PQJ5Primary (citable) accession number: Q5PQJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | September 29, 2021 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |