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Protein

Rho GTPase-activating protein 29

Gene

Arhgap29

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri609 – 654Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST46

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 29
Alternative name(s):
Rho-type GTPase-activating protein 29
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1306185 Arhgap29

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175841 – 1266Rho GTPase-activating protein 29Add BLAST1266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei496PhosphoserineBy similarity1
Modified residuei516PhosphoserineBy similarity1
Modified residuei549PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei951PhosphoserineBy similarity1
Modified residuei1023PhosphoserineBy similarity1
Modified residuei1149PhosphoserineBy similarity1
Modified residuei1151PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQJ5
PRIDEiQ5PQJ5

PTM databases

iPTMnetiQ5PQJ5
PhosphoSitePlusiQ5PQJ5

Expressioni

Gene expression databases

BgeeiENSRNOG00000012563 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ5PQJ5 baseline and differential

Interactioni

Subunit structurei

Interacts with PTPN13/PTPL1. Interacts with RAP2A via its coiled coil domain (By similarity). Interacts with RASIP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi259768, 1 interactor
STRINGi10116.ENSRNOP00000017076

Structurei

3D structure databases

ProteinModelPortaliQ5PQJ5
SMRiQ5PQJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 457F-BARPROSITE-ProRule annotationAdd BLAST271
Domaini668 – 883Rho-GAPPROSITE-ProRule annotationAdd BLAST216

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1263 – 1266Interaction with PTPN13/PTPL1By similarity4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili291 – 413Sequence analysisAdd BLAST123

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri609 – 654Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1453 Eukaryota
ENOG410YM3I LUCA
GeneTreeiENSGT00920000148941
HOGENOMiHOG000043077
HOVERGENiHBG108406
InParanoidiQ5PQJ5
KOiK20644
PhylomeDBiQ5PQJ5

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR002219 PE/DAG-bd
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50238 RHOGAP, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5PQJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIAHKQKKAK KKRVWASGQL SAAITTSEMG LKSVSSNSIF DPEYIKELVN
60 70 80 90 100
DIRKFSHVLL YLKEAILSDC FKEVIHIRLD ELLHMSKHQN LNSVDLQNAA
110 120 130 140 150
ETLASKVKAV NFTEVNDENK NDLFREVFSS IETLAFTFGN ILTNFLMGDV
160 170 180 190 200
GNDSILRLPI SRESKSFENI SMDSVDLPHE KGNFSPIELD NLLLKNSDSI
210 220 230 240 250
ELALSYAKTW SKYTKNIVSW VEKKLNLELE STRNIVKLAE ATRSSIGIQE
260 270 280 290 300
FMPLQSLFTN ALLNDIHSSH LLQQTIAALQ ANKFVQPLLG RKNEMEKQRK
310 320 330 340 350
EIKELWKQQQ NKLLETETAL KKAKLLCMQR QDEYEKAKSS MFRAEEEQLS
360 370 380 390 400
SSVGLGKNLN KLLEKRRRLE EEALQKVEEA NEHYKVCVTN VEERRNDLEN
410 420 430 440 450
TKREILTQLR TLVFQCDLTL KAVTVNLFHM QQLQAASLAN SLQSLCDSAK
460 470 480 490 500
LYDPGQEYSE FVKATSSSEL EEKVDGNVNK QIASSPQTSG YEPADSLEDV
510 520 530 540 550
ARLPDSCHKL EEDRCSNSAD MTGPSFIRSW KFGMFSDSES TGGSSESRSL
560 570 580 590 600
DSESISPGDF HRKLPRTPSS GTMSSADDLD EREPPSPSEA GPNSLGTFKK
610 620 630 640 650
TLMSKAALTH KFRKLRSPTK CRDCEGIVMF PGVECEECLL VCHRKCLENL
660 670 680 690 700
VIVCGHQKLQ GKMHIFGAEF IQVAKKEPDG IPFVLKICAS EIESRALCLQ
710 720 730 740 750
GIYRVCGNKI KTEKLCQALE NGMHLVDISE FSSHDICDVL KLYLRQLPEP
760 770 780 790 800
FILFRLYKEF IDLAKEIQHV NEEQEAKKDS PEDKKHPHVS IEINRILLRS
810 820 830 840 850
KDLLRQLPAS NFNSLHYLIV HLKRVVDHAE ENKMNSKNLG VIFGPTLIRP
860 870 880 890 900
RPTTAPVTIS SLAEYSSQAR VVEFLITYAQ KIFDGSLQPQ AGVIANTGAI
910 920 930 940 950
APQVDHGCHP KPLLSPDERD SDHSLKQLFF SSKEDIRTMD CESKTFELTT
960 970 980 990 1000
SFEESERKQN ALGKCDAPIL DNKVHLLFDQ ELESASHKTE DTCKSPKLLL
1010 1020 1030 1040 1050
LRSDRVANSV QRPTPRTRLR PVSLPVDRLL LLAGSPTERS SRNTGNTDSD
1060 1070 1080 1090 1100
KFGKNAAFEG LHRKDNSNTT CSKVNGFDQQ NVQKSWDKQN ERNSFTAKTT
1110 1120 1130 1140 1150
VIIPSAYAEK GLAVSTGNNR GHSSGAAQPS KAHADPARSA RDTSEHSSSD
1160 1170 1180 1190 1200
SCPVAAVRAP RTLQPQHWTT FYKPPNPTFN VRGTEEKTAF PSAAVPPVLV
1210 1220 1230 1240 1250
HAPQSHVAKS DPDLEATLAC PVQTSGQPKE SSEEPGLPEG TPTCQRPRLK
1260
RMQQFEDLED EIPQFV
Length:1,266
Mass (Da):141,943
Last modified:February 5, 2008 - v2
Checksum:iD08AB730726E94D1
GO
Isoform 2 (identifier: Q5PQJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Note: No experimental confirmation.
Show »
Length:1,182
Mass (Da):132,321
Checksum:i1DECAEB495B6D3EB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LPZ1F1LPZ1_RAT
Rho GTPase-activating protein 29
Arhgap29 rCG_28970
1,271Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310611 – 84Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03012575 Genomic DNA No translation available.
BC087167 mRNA Translation: AAH87167.1
RefSeqiNP_001009405.1, NM_001009405.1 [Q5PQJ5-2]
UniGeneiRn.162617

Genome annotation databases

EnsembliENSRNOT00000066486; ENSRNOP00000062636; ENSRNOG00000012563 [Q5PQJ5-2]
GeneIDi310833
KEGGirno:310833
UCSCiRGD:1306185 rat [Q5PQJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03012575 Genomic DNA No translation available.
BC087167 mRNA Translation: AAH87167.1
RefSeqiNP_001009405.1, NM_001009405.1 [Q5PQJ5-2]
UniGeneiRn.162617

3D structure databases

ProteinModelPortaliQ5PQJ5
SMRiQ5PQJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi259768, 1 interactor
STRINGi10116.ENSRNOP00000017076

PTM databases

iPTMnetiQ5PQJ5
PhosphoSitePlusiQ5PQJ5

Proteomic databases

PaxDbiQ5PQJ5
PRIDEiQ5PQJ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066486; ENSRNOP00000062636; ENSRNOG00000012563 [Q5PQJ5-2]
GeneIDi310833
KEGGirno:310833
UCSCiRGD:1306185 rat [Q5PQJ5-1]

Organism-specific databases

CTDi9411
RGDi1306185 Arhgap29

Phylogenomic databases

eggNOGiKOG1453 Eukaryota
ENOG410YM3I LUCA
GeneTreeiENSGT00920000148941
HOGENOMiHOG000043077
HOVERGENiHBG108406
InParanoidiQ5PQJ5
KOiK20644
PhylomeDBiQ5PQJ5

Enzyme and pathway databases

ReactomeiR-RNO-194840 Rho GTPase cycle

Miscellaneous databases

PROiPR:Q5PQJ5

Gene expression databases

BgeeiENSRNOG00000012563 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ5PQJ5 baseline and differential

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR002219 PE/DAG-bd
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50238 RHOGAP, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHG29_RAT
AccessioniPrimary (citable) accession number: Q5PQJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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