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Protein

Mitochondrial inner membrane protease subunit 2

Gene

immp2l

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40By similarity1
Active sitei88By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protease subunit 2 (EC:3.4.21.-)
Alternative name(s):
IMP2-like protein
Gene namesi
Name:immp2l
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1010852 immp2l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 31HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595801 – 170Mitochondrial inner membrane protease subunit 2Add BLAST170

Proteomic databases

PRIDEiQ5PQ63

Interactioni

Subunit structurei

Heterodimer of 2 subunits, IMMPL1 and IMMPL2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5PQ63
SMRiQ5PQ63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family. IMP2 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG081792
KOiK09648

Family and domain databases

InterProiView protein in InterPro
IPR037730 IMP2
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR015927 Peptidase_S24_S26A/B/C
PANTHERiPTHR12383:SF3 PTHR12383:SF3, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PQ63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQHGRRYVR AFISGFFVAV PVTVTFLDRV ACIARVEGVS MQPSLNPDAR
60 70 80 90 100
GESDIVLLNR WRARNYDVQR GDIVSLVSPK NPEQKIIKRV IALEGDIVKT
110 120 130 140 150
LGHKNRYVKV PRGHVWVEGD HHGHSFDSNA FGPVSLGLLH SHATHILWPP
160 170
NRWQKLKPFL PVERESVQND
Length:170
Mass (Da):19,269
Last modified:January 4, 2005 - v1
Checksum:iD92E09E30CCFF710
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087345 mRNA Translation: AAH87345.1
RefSeqiNP_001088705.1, NM_001095236.1
XP_018106654.1, XM_018251165.1
UniGeneiXl.48705
Xl.49939

Genome annotation databases

GeneIDi495969
KEGGixla:495969

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087345 mRNA Translation: AAH87345.1
RefSeqiNP_001088705.1, NM_001095236.1
XP_018106654.1, XM_018251165.1
UniGeneiXl.48705
Xl.49939

3D structure databases

ProteinModelPortaliQ5PQ63
SMRiQ5PQ63
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5PQ63

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi495969
KEGGixla:495969

Organism-specific databases

CTDi495969
XenbaseiXB-GENE-1010852 immp2l

Phylogenomic databases

HOVERGENiHBG081792
KOiK09648

Family and domain databases

InterProiView protein in InterPro
IPR037730 IMP2
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR015927 Peptidase_S24_S26A/B/C
PANTHERiPTHR12383:SF3 PTHR12383:SF3, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00761 SPASE_I_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIMP2L_XENLA
AccessioniPrimary (citable) accession number: Q5PQ63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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