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UniProtKB - Q5PPN0 (Q5PPN0_RAT)
Protein
Submitted name:
Hairy and enhancer of split 6 (Drosophila)
Gene
Hes6
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- cell differentiation Source: RGD
- negative regulation of DNA-binding transcription factor activity Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- nervous system development Source: RGD
- regulation of neurogenesis Source: GO_Central
- regulation of transcription by RNA polymerase II Source: RGD
Keywordsi
Molecular function | RepressorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Hairy and enhancer of split 6 (Drosophila)ImportedSubmitted name: Hes family bHLH transcription factor 6 |
Gene namesi | Name:Hes6Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1312047, Hes6 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- transcription regulator complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000020194, Expressed in liver and 21 other tissues |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000063598 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 87 | BHLHInterPro annotationAdd BLAST | 53 | |
Domaini | 106 – 139 | OrangeInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 214 | DisorderedSequence analysisAdd BLAST | 53 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000161398 |
OMAi | SAVSKCM |
OrthoDBi | 1483774at2759 |
TreeFami | TF351373 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5PPN0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTVGKHGGT ARCGQGLRVD GPAGGCTGQG LSSRFPQARK PLVEKKRRAR
60 70 80 90 100
INESLQELRL LLAGTEVQAK LENAEVLELT VRRVQGALRG RAREREQLQA
110 120 130 140 150
EASERFAAGY IQCMHEVHTF VSTCQAIDAT VSAELLNHLL ESMPLREGSS
160 170 180 190 200
FRDLLGDSLA GLPGGSGRSS WPPGGSPESP LSSPPGPGDD LCSDLEEIPE
210 220 230
AELNRVPAEG PDLVPTSLGI LTTARRAQSV WRPW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K6W4 | A0A0G2K6W4_RAT | Hairy and enhancer of split 6 (Dros... | Hes6 rCG_55552 | 224 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC087597 mRNA Translation: AAH87597.1 |
RefSeqi | NP_001013197.1, NM_001013179.1 |
Genome annotation databases
Ensembli | ENSRNOT00000066346.3; ENSRNOP00000063598.1; ENSRNOG00000020194.8 |
GeneIDi | 316626 |
KEGGi | rno:316626 |
UCSCi | RGD:1312047, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC087597 mRNA Translation: AAH87597.1 |
RefSeqi | NP_001013197.1, NM_001013179.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000063598 |
Genome annotation databases
Ensembli | ENSRNOT00000066346.3; ENSRNOP00000063598.1; ENSRNOG00000020194.8 |
GeneIDi | 316626 |
KEGGi | rno:316626 |
UCSCi | RGD:1312047, rat |
Organism-specific databases
CTDi | 55502 |
RGDi | 1312047, Hes6 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000161398 |
OMAi | SAVSKCM |
OrthoDBi | 1483774at2759 |
TreeFami | TF351373 |
Gene expression databases
Bgeei | ENSRNOG00000020194, Expressed in liver and 21 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5PPN0_RAT | |
Accessioni | Q5PPN0Primary (citable) accession number: Q5PPN0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 4, 2005 |
Last sequence update: | January 4, 2005 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |