UniProtKB - Q5PPJ9 (SHLB2_RAT)
Protein
Endophilin-B2
Gene
Sh3glb2
Organism
Rattus norvegicus (Rat)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Endophilin-B2Alternative name(s): SH3 domain-containing GRB2-like protein B2 |
Gene namesi | Name:Sh3glb2Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1305886, Sh3glb2 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307713 | 1 – 404 | Endophilin-B2Add BLAST | 404 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 10 | PhosphoserineBy similarity | 1 | |
Modified residuei | 404 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q5PPJ9 |
PaxDbi | Q5PPJ9 |
PRIDEi | Q5PPJ9 |
PTM databases
iPTMneti | Q5PPJ9 |
PhosphoSitePlusi | Q5PPJ9 |
SwissPalmi | Q5PPJ9 |
Interactioni
Subunit structurei
Homodimer, and heterodimer with SH3GLB1.
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 260069, 2 interactors |
IntActi | Q5PPJ9, 1 interactor |
STRINGi | 10116.ENSRNOP00000023527 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 291 | BARPROSITE-ProRule annotationAdd BLAST | 268 | |
Domaini | 344 – 404 | SH3PROSITE-ProRule annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | Membrane-binding amphipathic helixBy similarityAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 209 – 239 | Sequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the endophilin family.Sequence analysis
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG3725, Eukaryota |
InParanoidi | Q5PPJ9 |
OrthoDBi | 803053at2759 |
PhylomeDBi | Q5PPJ9 |
Family and domain databases
CDDi | cd11944, SH3_Endophilin_B2, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR004148, BAR_dom IPR035640, Endophilin_B2_SH3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF03114, BAR, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00721, BAR, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51021, BAR, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5PPJ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK
60 70 80 90 100
NWTERILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAE
110 120 130 140 150
AASELGPNTP YGKTLMKVSE AEKRLGAAER DFIHTASLSF LTPLRNFLEG
160 170 180 190 200
DWKTISKERR LLQNRRLDLD ACKARLKKAK AAEAKATCEG DTVPDFQETR
210 220 230 240 250
PRNYILSASA SALWNDEVDK AEQELRAAQT EFDRQAEVTR LLLEGISSAH
260 270 280 290 300
VNHLRCLHEF VKSQTTYYAQ CYRHMLDLQK QLGSSQGAIF PGTFVGTTEP
310 320 330 340 350
ASPPLSSTSP TTTAATMPVV PTGAGLAPPE EAALCLEEVA PPASGTRKAR
360 370 380 390 400
VLYDYEAADS SELALLADEL ITVYSLPGMD PDWLIGERGN KKGKVPVTYL
ELLS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K9P4 | A0A0G2K9P4_RAT | Endophilin-B2 | Sh3glb2 | 400 | Annotation score: | ||
D4A7V1 | D4A7V1_RAT | Endophilin-B2 | Sh3glb2 | 330 | Annotation score: |
Sequence cautioni
The sequence AAH87652 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC087652 mRNA Translation: AAH87652.1 Frameshift. |
RefSeqi | NP_001009692.1, NM_001009692.1 XP_006233880.1, XM_006233818.3 |
Genome annotation databases
GeneIDi | 311848 |
KEGGi | rno:311848 |
UCSCi | RGD:1305886, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC087652 mRNA Translation: AAH87652.1 Frameshift. |
RefSeqi | NP_001009692.1, NM_001009692.1 XP_006233880.1, XM_006233818.3 |
3D structure databases
SMRi | Q5PPJ9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 260069, 2 interactors |
IntActi | Q5PPJ9, 1 interactor |
STRINGi | 10116.ENSRNOP00000023527 |
PTM databases
iPTMneti | Q5PPJ9 |
PhosphoSitePlusi | Q5PPJ9 |
SwissPalmi | Q5PPJ9 |
Proteomic databases
jPOSTi | Q5PPJ9 |
PaxDbi | Q5PPJ9 |
PRIDEi | Q5PPJ9 |
Genome annotation databases
GeneIDi | 311848 |
KEGGi | rno:311848 |
UCSCi | RGD:1305886, rat |
Organism-specific databases
CTDi | 56904 |
RGDi | 1305886, Sh3glb2 |
Phylogenomic databases
eggNOGi | KOG3725, Eukaryota |
InParanoidi | Q5PPJ9 |
OrthoDBi | 803053at2759 |
PhylomeDBi | Q5PPJ9 |
Miscellaneous databases
PROi | PR:Q5PPJ9 |
Family and domain databases
CDDi | cd11944, SH3_Endophilin_B2, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR004148, BAR_dom IPR035640, Endophilin_B2_SH3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF03114, BAR, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00721, BAR, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51021, BAR, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHLB2_RAT | |
Accessioni | Q5PPJ9Primary (citable) accession number: Q5PPJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 99 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families