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Protein

Eukaryotic translation initiation factor 2D

Gene

Eif2d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2D
Short name:
eIF2d
Alternative name(s):
Ligatin
Gene namesi
Name:Eif2d
Synonyms:Lgtn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1561765 Eif2d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001306141 – 570Eukaryotic translation initiation factor 2DAdd BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei238PhosphoserineBy similarity1
Modified residuei241PhosphoserineBy similarity1
Modified residuei348PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PPG7
PRIDEiQ5PPG7

PTM databases

iPTMnetiQ5PPG7
PhosphoSitePlusiQ5PPG7

Expressioni

Gene expression databases

BgeeiENSRNOG00000004910 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ5PPG7 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006768

Structurei

3D structure databases

ProteinModelPortaliQ5PPG7
SMRiQ5PPG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 173PUAPROSITE-ProRule annotationAdd BLAST81
Domaini478 – 551SUI1PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the eIF2D family.Curated

Phylogenomic databases

eggNOGiKOG2522 Eukaryota
ENOG410XSAV LUCA
GeneTreeiENSGT00550000074865
HOVERGENiHBG006268
InParanoidiQ5PPG7
KOiK15027
OMAiREQPYHP
OrthoDBiEOG091G0DTH
PhylomeDBiQ5PPG7
TreeFamiTF105830

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR036885 SWIB_MDM2_dom_sf
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF47592 SSF47592, 1 hit
SSF55159 SSF55159, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit
PS50296 SUI1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PPG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFAKAFRVKS NTAIKGSDRR KLRADVTVAF PTLGTDQVSE LIPGKEELNV
60 70 80 90 100
VKLYAHKGDA VTVYTSGGNP ILFELEKNLY PTVYTLWSHP DLLPAFITWP
110 120 130 140 150
LVLEKLVGGA DLMLPGVVVP PTGLPQVQQG DLCAIALVGN RAPVAVGVAA
160 170 180 190 200
MSTAQMLASG LKGKGISVLH TYQDHLWRSG DKSSPPAIAP LDPTDSCEEK
210 220 230 240 250
ADLGLHGNLR SLSLEGEEEN GQVPNPEASD DPNSRALSQD SVDGKPLQEQ
260 270 280 290 300
MDELLEQCFL HALKSRVKKA DLPLLTSTLL GSHMFSCCPE GQQLDIKKSS
310 320 330 340 350
YKKLSKFLQH MQQEQIVQVK ELSKGVESIV AVDWRHPRIT SFIVPEPSLA
360 370 380 390 400
SQTVQEGSRE KPYLPPDIKS LYCVPANMTQ LFLESGHKKG STLEGSEVRR
410 420 430 440 450
IITDYAKRNN LVDADNRNLV KLDPILCDCI LEKNEQHLVM KLPWDSLLTR
460 470 480 490 500
CLKNLQPAYQ VTFPGQEPII KKGKLCPIDI TLVLKTYNKK VTVVRNLETY
510 520 530 540 550
GLDPCSVAAI LQQRCQASTI VSPAPGAKDS LQVQVQGNQI HHLGQLLLEE
560 570
YRLPGKYIQG LEKAPKPGKK
Length:570
Mass (Da):62,669
Last modified:January 4, 2005 - v1
Checksum:i97434C5FD17DD457
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087701 mRNA Translation: AAH87701.1
RefSeqiNP_001017489.1, NM_001017489.1
UniGeneiRn.162387

Genome annotation databases

EnsembliENSRNOT00000006768; ENSRNOP00000006768; ENSRNOG00000004910
GeneIDi498225
KEGGirno:498225
UCSCiRGD:1561765 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087701 mRNA Translation: AAH87701.1
RefSeqiNP_001017489.1, NM_001017489.1
UniGeneiRn.162387

3D structure databases

ProteinModelPortaliQ5PPG7
SMRiQ5PPG7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006768

PTM databases

iPTMnetiQ5PPG7
PhosphoSitePlusiQ5PPG7

Proteomic databases

PaxDbiQ5PPG7
PRIDEiQ5PPG7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006768; ENSRNOP00000006768; ENSRNOG00000004910
GeneIDi498225
KEGGirno:498225
UCSCiRGD:1561765 rat

Organism-specific databases

CTDi1939
RGDi1561765 Eif2d

Phylogenomic databases

eggNOGiKOG2522 Eukaryota
ENOG410XSAV LUCA
GeneTreeiENSGT00550000074865
HOVERGENiHBG006268
InParanoidiQ5PPG7
KOiK15027
OMAiREQPYHP
OrthoDBiEOG091G0DTH
PhylomeDBiQ5PPG7
TreeFamiTF105830

Miscellaneous databases

PROiPR:Q5PPG7

Gene expression databases

BgeeiENSRNOG00000004910 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ5PPG7 RN

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR036885 SWIB_MDM2_dom_sf
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF47592 SSF47592, 1 hit
SSF55159 SSF55159, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit
PS50296 SUI1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEIF2D_RAT
AccessioniPrimary (citable) accession number: Q5PPG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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