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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224UniRule annotation1
Active sitei226UniRule annotation1
Active sitei231UniRule annotation1
Active sitei404UniRule annotation1
Active sitei406UniRule annotation1
Active sitei411UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:SPA1138
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008185 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000584921 – 486Cardiolipin synthase AAdd BLAST486

Structurei

3D structure databases

ProteinModelPortaliQ5PCS9
SMRiQ5PCS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 246PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini399 – 426PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000077403
KOiK06131
OMAiGGHNVGD

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q5PCS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTFYTVVSW LVILGYWVLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV
60 70 80 90 100
GIIAYLSVGE LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAQENSSVA
110 120 130 140 150
SSLFKLCERR QGIAGVKGNQ LQLLTDSDDV MQALIRDIQL ARHNIEMVFY
160 170 180 190 200
IWQPGGMADQ VAESLMAAAR RDIHCRLMLD SAGSVAFFRS PWAAMMRNAG
210 220 230 240 250
IEVVEALKVN LMRVFLRRMD LRQHRKMVMI DNYIAYTGSM NMVDPRFFKQ
260 270 280 290 300
DAGVGQWVDL MARMEGPVAT AMGIVYSCDW EIETGKRILP PPPDVNIMPF
310 320 330 340 350
EQASGHTIHT IASGPGFPED LIHQALLTAT YAAREYLIMT TPYFVPSDDL
360 370 380 390 400
LHAICTAAQR GVDVSIILPR KNDSLLVGWA SRAFFSELLA AGVKIYQFEG
410 420 430 440 450
GLLHTKSVLV DGELSLVGTV NLDMRSLWLN FEITLVIDDT GFGADLAAVQ
460 470 480
DDYISRSRLL DARLWVKRPL WQRITERLFY FFSPLL
Length:486
Mass (Da):54,792
Last modified:January 4, 2005 - v1
Checksum:iA7A7F9BF8A54D1C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA Translation: AAV77099.1
RefSeqiWP_000206883.1, NC_006511.1

Genome annotation databases

EnsemblBacteriaiAAV77099; AAV77099; SPA1138
KEGGispt:SPA1138

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA Translation: AAV77099.1
RefSeqiWP_000206883.1, NC_006511.1

3D structure databases

ProteinModelPortaliQ5PCS9
SMRiQ5PCS9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV77099; AAV77099; SPA1138
KEGGispt:SPA1138

Phylogenomic databases

HOGENOMiHOG000077403
KOiK06131
OMAiGGHNVGD

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCLSA_SALPA
AccessioniPrimary (citable) accession number: Q5PCS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 4, 2005
Last modified: July 18, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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