UniProtKB - Q5NVS2 (TTHY_PONAB)
Protein
Transthyretin
Gene
TTR
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 35 | Thyroid hormoneBy similarity | 1 | |
Binding sitei | 74 | Thyroid hormoneBy similarity | 1 |
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- thyroid hormone binding Source: InterPro
GO - Biological processi
- retinol metabolic process Source: InterPro
- thyroid hormone transport Source: InterPro
Keywordsi
Molecular function | Hormone, Thyroid hormone |
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: TransthyretinAlternative name(s): Prealbumin |
Gene namesi | Name:TTR |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
ChainiPRO_0000045960 | 21 – 147 | TransthyretinAdd BLAST | 127 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 62 | 4-carboxyglutamateBy similarity | 1 | |
Modified residuei | 72 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Gamma-carboxyglutamic acid, Glycoprotein, PhosphoproteinProteomic databases
PRIDEi | Q5NVS2 |
Expressioni
Tissue specificityi
Detected in liver.
Interactioni
Subunit structurei
Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules.
Interacts with RBP4 (By similarity).
By similarityGO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000010206 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 139 | Thyroid hormone bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the transthyretin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3006, Eukaryota |
InParanoidi | Q5NVS2 |
OrthoDBi | 1453185at2759 |
Family and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR023418, Thyroxine_BS IPR030178, Transthyretin IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf IPR023419, Transthyretin_CS |
PANTHERi | PTHR10395, PTHR10395, 1 hit PTHR10395:SF12, PTHR10395:SF12, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SMARTi | View protein in SMART SM00095, TR_THY, 1 hit |
SUPFAMi | SSF49472, SSF49472, 1 hit |
PROSITEi | View protein in PROSITE PS00768, TRANSTHYRETIN_1, 1 hit PS00769, TRANSTHYRETIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5NVS2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASHRLLLLC LAGLVFVSEA GPTGAGESKC PLMVKVLDAV RGSPAVNVAV
60 70 80 90 100
NVFKRAADET WEPFASGKTS ESGELHGLTT EEEFVEGIYK VEIDTKSYWK
110 120 130 140
ALGISPFHEH AEVVFAANDS GPRRYTIAAL LSPYSYSTTA VVTNPKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR925931 mRNA Translation: CAI29591.1 |
RefSeqi | NP_001127064.1, NM_001133592.2 |
Genome annotation databases
GeneIDi | 100174094 |
KEGGi | pon:100174094 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR925931 mRNA Translation: CAI29591.1 |
RefSeqi | NP_001127064.1, NM_001133592.2 |
3D structure databases
SMRi | Q5NVS2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000010206 |
Proteomic databases
PRIDEi | Q5NVS2 |
Genome annotation databases
GeneIDi | 100174094 |
KEGGi | pon:100174094 |
Organism-specific databases
CTDi | 7276 |
Phylogenomic databases
eggNOGi | KOG3006, Eukaryota |
InParanoidi | Q5NVS2 |
OrthoDBi | 1453185at2759 |
Family and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR023418, Thyroxine_BS IPR030178, Transthyretin IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf IPR023419, Transthyretin_CS |
PANTHERi | PTHR10395, PTHR10395, 1 hit PTHR10395:SF12, PTHR10395:SF12, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SMARTi | View protein in SMART SM00095, TR_THY, 1 hit |
SUPFAMi | SSF49472, SSF49472, 1 hit |
PROSITEi | View protein in PROSITE PS00768, TRANSTHYRETIN_1, 1 hit PS00769, TRANSTHYRETIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTHY_PONAB | |
Accessioni | Q5NVS2Primary (citable) accession number: Q5NVS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | January 4, 2005 | |
Last modified: | December 2, 2020 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families