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Protein

Neuronal regeneration-related protein

Gene

NREP

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May have roles in neural function and cellular differentiation. Ectopic expression promotes axonal regeneration, induces differentiation of fibroblast into myofibroblast, induces myofibroblast ameboid migration, augments motility of gliomas, and increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal regeneration-related protein
Alternative name(s):
Neuronal protein 3.1
Protein p311
Gene namesi
Name:NREP
Synonyms:P311
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535961 – 68Neuronal regeneration-related proteinAdd BLAST68

Post-translational modificationi

Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5NVD3

Interactioni

Subunit structurei

Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction. Interacts with FLNA.By similarity

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG052654
InParanoidiQ5NVD3

Family and domain databases

InterProiView protein in InterPro
IPR024417 Neuronal_3.1
PANTHERiPTHR17102 PTHR17102, 1 hit
PfamiView protein in Pfam
PF11092 Alveol-reg_P311, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD019364 PD019364, 1 hit

Sequencei

Sequence statusi: Complete.

Q5NVD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVYYPELSVW VSQEPFPNKD MEGRLPKGRL PVPKEVNRKK NDETNAASLT
60
PLGSSELRSP RISYLHSF
Length:68
Mass (Da):7,789
Last modified:January 4, 2005 - v1
Checksum:i520D5BC93CC15137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR926104 mRNA Translation: CAI29730.1
RefSeqiNP_001127120.1, NM_001133648.1
UniGeneiPab.18381

Genome annotation databases

GeneIDi100174166
KEGGipon:100174166

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR926104 mRNA Translation: CAI29730.1
RefSeqiNP_001127120.1, NM_001133648.1
UniGeneiPab.18381

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5NVD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174166
KEGGipon:100174166

Organism-specific databases

CTDi9315

Phylogenomic databases

HOVERGENiHBG052654
InParanoidiQ5NVD3

Family and domain databases

InterProiView protein in InterPro
IPR024417 Neuronal_3.1
PANTHERiPTHR17102 PTHR17102, 1 hit
PfamiView protein in Pfam
PF11092 Alveol-reg_P311, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD019364 PD019364, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNREP_PONAB
AccessioniPrimary (citable) accession number: Q5NVD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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