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Protein

Palmitoyltransferase ZDHHC13

Gene

ZDHHC13

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase for HTT and GAD2. May play a role in Mg2+ transport.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei456S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.225By similarity)
Alternative name(s):
Zinc finger DHHC domain-containing protein 13By similarity
Short name:
DHHC-13By similarity
Gene namesi
Name:ZDHHC13By similarity
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128901 – 622Palmitoyltransferase ZDHHC13Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CLIP3. Interacts (via ANK repeats) with DNAJC5 (via C-terminus). Interacts (via ANK repeats) with HTT. Interacts (via ANK repeats) with MAP6. Interacts (via ANK repeats) with SNAP23. Interacts (via ANK repeats) with SNAP25. May interact (via ANK repeats) with SPRED2.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000003933

Structurei

3D structure databases

ProteinModelPortaliQ5NVB9
SMRiQ5NVB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 78ANK 1By similarityAdd BLAST36
Repeati81 – 110ANK 2Sequence analysisAdd BLAST30
Repeati115 – 144ANK 3Sequence analysisAdd BLAST30
Repeati148 – 177ANK 4Sequence analysisAdd BLAST30
Repeati181 – 211ANK 5Sequence analysisAdd BLAST31
Repeati216 – 245ANK 6Sequence analysisAdd BLAST30
Repeati249 – 277ANK 7Sequence analysisAdd BLAST29
Domaini426 – 476DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi328 – 391Phe-richAdd BLAST64

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509 Eukaryota
COG0666 LUCA
COG5273 LUCA
HOVERGENiHBG051907
InParanoidiQ5NVB9
KOiK20032

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
IPR030290 ZDHHC13
PANTHERiPTHR24161:SF16 PTHR24161:SF16, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01529 DHHC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5NVB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPGLGSQC RNHSHGPHPP GFGRYGICAH ENKELANARE ALPLIEDSSN
60 70 80 90 100
CDIVKATQYG IFERCKELVE AGYDVRQPDK ENVSLLHWAA INNRLDLVKF
110 120 130 140 150
YISKGAVVDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLIDGEGF
160 170 180 190 200
SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV NGQTPLMLSA HKVIGPEPTG
210 220 230 240 250
FLLKFNPSLN VVDKIHQNTP LHWAVAAGNV NAVDKLLEAG SSLDIQNVKG
260 270 280 290 300
ETPLDMALQN KNQLIIHMLK TEAKMRANQK FRLWRWLQKC ELFLLLMLSV
310 320 330 340 350
ITMWAVGYIL DFNSDSWLLK GCLLVTLFFL TSLFPRFLVG YKNLVYLPTA
360 370 380 390 400
FLLSSVFWIF MTWFILFFPD LAGAPFYFSF IFSIVAFLYF FYKTWATDPG
410 420 430 440 450
FTKASEEEKK VNIITLAETG SLDFRTFCTS CLIRKPLRSL HCHVCNSCVA
460 470 480 490 500
RYDQHCLWTG RCIGFGNHHY YIFFLFFLSM VCGWIIYGSF IYWSSHCATT
510 520 530 540 550
FKEDGLWTYL NQIVACSPWV LYILMLATFH FSWSTFLLLN QLFQIAFLGL
560 570 580 590 600
TSHERISLQK QSKHMKQTLS LRKTPYNLGF MQNLADFFQC GCFGLVKPCV
610 620
VDWTSQYTVV FHPAREKVLR SV
Length:622
Mass (Da):70,872
Last modified:January 4, 2005 - v1
Checksum:i9590D0BADB1C7AF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR926119 mRNA Translation: CAI29744.1
RefSeqiNP_001127125.1, NM_001133653.1
UniGeneiPab.274

Genome annotation databases

GeneIDi100174171
KEGGipon:100174171

Similar proteinsi

Entry informationi

Entry nameiZDH13_PONAB
AccessioniPrimary (citable) accession number: Q5NVB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: November 22, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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