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Protein

Selenoprotein W

Gene

SELENOW

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAntioxidant

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein WBy similarity
Short name:
SelWBy similarity
Gene namesi
Name:SELENOWBy similarity
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002651011 – 87Selenoprotein WAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki10 ↔ 13Cysteinyl-selenocysteine (Cys-Sec); redox-activeBy similarity
Modified residuei37S-glutathionyl cysteineBy similarity1

Keywords - PTMi

Glutathionylation

Interactioni

Subunit structurei

Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5NVB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOVERGENiHBG059755
InParanoidiQ5NVB2

Family and domain databases

InterProiView protein in InterPro
IPR011893 Selenoprotein_Rdx-typ
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF10262 Rdx, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02174 CXXU_selWTH, 1 hit

Sequencei

Sequence statusi: Complete.

Q5NVB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAVRVVYC GAUGYKSKYL QLKKKLEDEF PGRLDICGEG TPQATGFFEV
60 70 80
MVAGKLIHSK KKGDGYVDTE SKFLKLVAAI KAALAQG
Length:87
Mass (Da):9,448
Last modified:February 26, 2008 - v4
Checksum:iF8FDF3194B0654E9
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei13Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR926472 mRNA Translation: CAI30265.1
RefSeqiNP_001127129.1, NM_001133657.1
UniGeneiPab.9649

Genome annotation databases

GeneIDi100174175
KEGGipon:100174175

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSELW_PONAB
AccessioniPrimary (citable) accession number: Q5NVB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 26, 2008
Last modified: October 25, 2017
This is version 59 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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