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Protein

Endothelin-2

Gene

EDN2

Organism
Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.By similarity

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Gene namesi
Name:EDN2
OrganismiAtelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
Taxonomic identifieri9368 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeAtelerix

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000000807827 – 47By similarityAdd BLAST21
PeptideiPRO_000000807950 – 70Endothelin-2Add BLAST21
PropeptideiPRO_000000808071 – 180By similarityAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 64By similarity
Disulfide bondi52 ↔ 60By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei70 – 71Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Structurei

3D structure databases

SMRiQ5NRP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 112Endothelin-likeAdd BLAST16

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051441

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
IPR015658 ET-2
PANTHERiPTHR13874:SF9 PTHR13874:SF9, 1 hit
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NRP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVALPTAWCS VALALLVALH EGKSQSAATS EEPPAPSARA RGSHLRLRRC
60 70 80 90 100
SCNSWLDKEC VYFCHLDIIW VNTPGQTAPY GLGNPPRRQR RSLPRRCECY
110 120 130 140 150
STRDSACVTF CHQKPWPKAS AVPGEGSPTD LLWTSKTRTT AGELLRRLRD
160 170 180
IFAAKRNFTR HQQQKATREP ESSHSRWRKR
Length:180
Mass (Da):20,382
Last modified:February 1, 2005 - v1
Checksum:i08BBC520F8CFC753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB197701 mRNA Translation: BAD83373.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB197701 mRNA Translation: BAD83373.1

3D structure databases

SMRiQ5NRP8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG051441

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
IPR015658 ET-2
PANTHERiPTHR13874:SF9 PTHR13874:SF9, 1 hit
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEDN2_ATEAB
AccessioniPrimary (citable) accession number: Q5NRP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 1, 2005
Last modified: December 20, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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