Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE), Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Multifunctional fusion protein (trpF), Multifunctional fusion protein (trpC)
  4. Multifunctional fusion protein (trpF), Multifunctional fusion protein (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB), Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciFTUL177416:G1G1C-2051-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:FTT_1773c
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000001174 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000183451 – 396Tryptophan synthase beta chainAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

IntActiQ5NE79, 4 interactors
STRINGi177416.FTT_1773c

Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 10Combined sources4
Helixi18 – 20Combined sources3
Helixi21 – 36Combined sources16
Helixi38 – 50Combined sources13
Beta strandi58 – 60Combined sources3
Turni64 – 67Combined sources4
Beta strandi68 – 76Combined sources9
Helixi77 – 79Combined sources3
Helixi88 – 98Combined sources11
Turni99 – 101Combined sources3
Beta strandi104 – 108Combined sources5
Beta strandi110 – 112Combined sources3
Helixi113 – 124Combined sources12
Beta strandi128 – 134Combined sources7
Helixi135 – 140Combined sources6
Helixi142 – 150Combined sources9
Beta strandi154 – 158Combined sources5
Helixi165 – 179Combined sources15
Turni180 – 182Combined sources3
Beta strandi183 – 185Combined sources3
Beta strandi188 – 190Combined sources3
Helixi196 – 204Combined sources9
Helixi206 – 218Combined sources13
Beta strandi224 – 229Combined sources6
Beta strandi231 – 233Combined sources3
Helixi234 – 240Combined sources7
Helixi241 – 243Combined sources3
Beta strandi249 – 258Combined sources10
Helixi261 – 263Combined sources3
Turni270 – 272Combined sources3
Beta strandi274 – 278Combined sources5
Beta strandi281 – 285Combined sources5
Helixi301 – 303Combined sources3
Helixi310 – 317Combined sources8
Beta strandi320 – 327Combined sources8
Helixi328 – 340Combined sources13
Helixi348 – 363Combined sources16
Beta strandi369 – 375Combined sources7
Beta strandi377 – 379Combined sources3
Helixi380 – 382Combined sources3
Helixi383 – 393Combined sources11

3D structure databases

ProteinModelPortaliQ5NE79
SMRiQ5NE79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CG0 Bacteria
COG0133 LUCA
HOGENOMiHOG000161710
KOiK01696
OMAiHGMKSYF

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5NE79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLNAYFGE YGGQFVPQIL VPALDQLEQE FIKAQADESF KQEFKELLQE
60 70 80 90 100
YAGRPTALTK TRNIVKNTRT KLYLKREDLL HGGAHKTNQV LGQALLAKRM
110 120 130 140 150
GKKEIIAETG AGQHGVATAL ACALLDLKCR VYMGAKDVER QSPNVFRMKL
160 170 180 190 200
MGAEVIPVHS GSATLKDACN EALRDWSANY SKAHYLLGTA AGPHPFPTIV
210 220 230 240 250
REFQRMIGEE TKQQMLAKEG RLPDAVIACV GGGSNAIGMF ADFIDEKNVK
260 270 280 290 300
LIGVEPAGKG IETGEHGAPL KHGKTGIFFG MKAPLMQNSD GQIEESYSIS
310 320 330 340 350
AGLDFPSVGP QHAHLLAIGR AKYASATDDE ALDAFKLLCK KEGIIPALES
360 370 380 390
SHALAHALKL AYEDPNKEQL LVVNLSGRGD KDIFTVHDIL KEKGEI
Length:396
Mass (Da):43,079
Last modified:February 1, 2005 - v1
Checksum:iE2A4B441C8930606
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA Translation: CAG46406.1
RefSeqiWP_003022755.1, NZ_CP010290.1
YP_170663.1, NC_006570.2

Genome annotation databases

EnsemblBacteriaiCAG46406; CAG46406; FTT_1773c
GeneIDi3190984
KEGGiftu:FTT_1773c

Similar proteinsi

Entry informationi

Entry nameiTRPB_FRATT
AccessioniPrimary (citable) accession number: Q5NE79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health