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Entry version 109 (07 Apr 2021)
Sequence version 1 (01 Feb 2005)
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Protein

rRNA methyltransferase 3, mitochondrial

Gene

Mrm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei354S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei378S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei387S-adenosyl-L-methionine; via amide nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
rRNA methyltransferase 3, mitochondrialBy similarity (EC:2.1.1.-By similarity)
Alternative name(s):
16S rRNA (guanosine(1370)-2'-O)-methyltransferaseBy similarity
16S rRNA [Gm1370] 2'-O-methyltransferaseBy similarity
RNA methyltransferase-like protein 1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mrm3By similarity
Synonyms:Rnmtl1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914640, Mrm3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 40MitochondrionSequence analysisAdd BLAST40
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031130241 – 418rRNA methyltransferase 3, mitochondrialAdd BLAST378

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5ND52

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5ND52

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5ND52

PeptideAtlas

More...
PeptideAtlasi
Q5ND52

PRoteomics IDEntifications database

More...
PRIDEi
Q5ND52

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
291510

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5ND52

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5ND52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038046, Expressed in myocardium of ventricle and 283 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5ND52, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
212154, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000042882

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5ND52, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2506, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017317

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021322_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5ND52

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDPWESK

Database of Orthologous Groups

More...
OrthoDBi
1183644at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5ND52

TreeFam database of animal gene trees

More...
TreeFami
TF323420

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1330.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029028, Alpha/beta_knot_MTases
IPR029064, L30e-like
IPR001537, SpoU_MeTrfase
IPR013123, SpoU_subst-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00588, SpoU_methylase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00967, SpoU_sub_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55315, SSF55315, 1 hit
SSF75217, SSF75217, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ND52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPAKGMWC SLGSLLRVVQ TRDLNARRWV RALRRSPVRV LSPSGQVEER
60 70 80 90 100
KRAPDQQPRK AVPKASSQGQ RQKQPLETSP SQTPHTWEEA GLRYDKAFPG
110 120 130 140 150
DRRLSSVMTI VKSRPFREKQ GKILLEGRRL IADALKAGAV PKAFFFSRLE
160 170 180 190 200
YVKELPVDKL KDVSLIKVKF EDIKDWSDLV TPQGIMGIFA KPDPVKMTYP
210 220 230 240 250
ETPLHHTLPL VLICDNLRDP GNLGTILRSA AGAGCSKVLL TKGCVDAWEP
260 270 280 290 300
KVLRAGMGAH FQVPIVNNVE WETVPNHLPP DTRVYVADNC GHYAQVQMSD
310 320 330 340 350
KTGDRDWACD RRFLKFHKYE EDLDTKTRKD WLPKLEVQSY DLDWTGAPAA
360 370 380 390 400
VVIGGETHGV SLESLQLAES TGGKRLLIPV VPGVDSLNSA MAASILLFEG
410
KRQLRIKVED LSRDRSYH
Length:418
Mass (Da):46,796
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54E4A589B436141B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH38288 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH90975 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI15623 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI15624 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC25446 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102R → K in AAH38288 (PubMed:15489334).Curated1
Sequence conflicti102R → K in AAI15624 (PubMed:15489334).Curated1
Sequence conflicti102R → K in AAI15623 (PubMed:15489334).Curated1
Sequence conflicti203P → L in AAH38288 (PubMed:15489334).Curated1
Sequence conflicti203P → L in AAI15624 (PubMed:15489334).Curated1
Sequence conflicti203P → L in AAI15623 (PubMed:15489334).Curated1
Sequence conflicti350A → V in BAE28150 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK014739 mRNA Translation: BAC25446.1 Frameshift.
AK147805 mRNA Translation: BAE28150.1
AL591129 Genomic DNA No translation available.
BC038288 mRNA Translation: AAH38288.1 Different initiation.
BC090975 mRNA Translation: AAH90975.2 Different initiation.
BC115622 mRNA Translation: AAI15623.1 Different initiation.
BC115623 mRNA Translation: AAI15624.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48852.1

NCBI Reference Sequences

More...
RefSeqi
NP_899086.2, NM_183263.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040577; ENSMUSP00000042882; ENSMUSG00000038046

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67390

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67390

UCSC genome browser

More...
UCSCi
uc007kfn.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014739 mRNA Translation: BAC25446.1 Frameshift.
AK147805 mRNA Translation: BAE28150.1
AL591129 Genomic DNA No translation available.
BC038288 mRNA Translation: AAH38288.1 Different initiation.
BC090975 mRNA Translation: AAH90975.2 Different initiation.
BC115622 mRNA Translation: AAI15623.1 Different initiation.
BC115623 mRNA Translation: AAI15624.1 Different initiation.
CCDSiCCDS48852.1
RefSeqiNP_899086.2, NM_183263.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi212154, 1 interactor
STRINGi10090.ENSMUSP00000042882

PTM databases

iPTMnetiQ5ND52
PhosphoSitePlusiQ5ND52

Proteomic databases

EPDiQ5ND52
MaxQBiQ5ND52
PaxDbiQ5ND52
PeptideAtlasiQ5ND52
PRIDEiQ5ND52
ProteomicsDBi291510

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10311, 96 antibodies

Genome annotation databases

EnsembliENSMUST00000040577; ENSMUSP00000042882; ENSMUSG00000038046
GeneIDi67390
KEGGimmu:67390
UCSCiuc007kfn.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55178
MGIiMGI:1914640, Mrm3

Phylogenomic databases

eggNOGiKOG2506, Eukaryota
GeneTreeiENSGT00390000017317
HOGENOMiCLU_021322_1_0_1
InParanoidiQ5ND52
OMAiCDPWESK
OrthoDBi1183644at2759
PhylomeDBiQ5ND52
TreeFamiTF323420

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
67390, 7 hits in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q5ND52
RNActiQ5ND52, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038046, Expressed in myocardium of ventricle and 283 other tissues
GenevisibleiQ5ND52, MM

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029028, Alpha/beta_knot_MTases
IPR029064, L30e-like
IPR001537, SpoU_MeTrfase
IPR013123, SpoU_subst-bd
PfamiView protein in Pfam
PF00588, SpoU_methylase, 1 hit
SMARTiView protein in SMART
SM00967, SpoU_sub_bind, 1 hit
SUPFAMiSSF55315, SSF55315, 1 hit
SSF75217, SSF75217, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRM3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5ND52
Secondary accession number(s): A4FUR4
, Q3UGQ7, Q5U5W2, Q8C1J9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 1, 2005
Last modified: April 7, 2021
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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