UniProtKB - Q5ND51 (Q5ND51_MOUSE)
Protein
Submitted name:
V-crk sarcoma virus CT10 oncogene-like protein
Gene
Crk
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cytoskeletal protein binding Source: Ensembl
- ephrin receptor binding Source: Ensembl
- insulin-like growth factor receptor binding Source: Ensembl
- phosphotyrosine residue binding Source: Ensembl
- protein self-association Source: Ensembl
- protein tyrosine kinase binding Source: Ensembl
- scaffold protein binding Source: Ensembl
- SH2 domain binding Source: Ensembl
- SH3 domain binding Source: Ensembl
- signaling adaptor activity Source: Ensembl
GO - Biological processi
- actin cytoskeleton organization Source: Ensembl
- cellular response to endothelin Source: Ensembl
- cellular response to insulin-like growth factor stimulus Source: Ensembl
- cellular response to nerve growth factor stimulus Source: Ensembl
- cellular response to nitric oxide Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- ephrin receptor signaling pathway Source: Ensembl
- negative regulation of cell motility Source: Ensembl
- negative regulation of natural killer cell mediated cytotoxicity Source: Ensembl
- negative regulation of wound healing Source: Ensembl
- positive regulation of smooth muscle cell migration Source: Ensembl
- positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
- regulation of actin cytoskeleton organization Source: Ensembl
- regulation of cell shape Source: Ensembl
- regulation of GTPase activity Source: Ensembl
- regulation of protein binding Source: Ensembl
- regulation of Rac protein signal transduction Source: Ensembl
- response to cholecystokinin Source: Ensembl
- response to hepatocyte growth factor Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to yeast Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: V-crk sarcoma virus CT10 oncogene-like proteinImported |
Gene namesi | Name:CrkImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:88508, Crk |
Subcellular locationi
Other locations
- membrane raft Source: Ensembl
- protein-containing complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000017776, Expressed in placenta and 310 other tissues |
ExpressionAtlasi | Q5ND51, baseline and differential |
Interactioni
GO - Molecular functioni
- cytoskeletal protein binding Source: Ensembl
- ephrin receptor binding Source: Ensembl
- insulin-like growth factor receptor binding Source: Ensembl
- phosphotyrosine residue binding Source: Ensembl
- protein self-association Source: Ensembl
- protein tyrosine kinase binding Source: Ensembl
- scaffold protein binding Source: Ensembl
- SH2 domain binding Source: Ensembl
- SH3 domain binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 118 | SH2InterPro annotationAdd BLAST | 106 | |
Domaini | 132 – 192 | SH3InterPro annotationAdd BLAST | 61 | |
Domaini | 235 – 296 | SH3InterPro annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 60 – 85 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 201 – 229 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 66 – 82 | Pro-richSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the CRK family.ARBA annotation
Keywords - Domaini
SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_060542_0_1_1 |
OrthoDBi | 1414461at2759 |
Family and domain databases
CDDi | cd11759, SH3_CRK_C, 1 hit cd11758, SH3_CRK_N, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035458, CRK_SH3_C IPR035457, CRK_SH3_N IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF50044, SSF50044, 2 hits SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 2 hits |
i Sequence
Sequence statusi: Complete.
Q5ND51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS
60 70 80 90 100
VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL
110 120 130 140 150
LEFYKIHYLD TTTLIEPVAR SRQGSGVILR QEEAEYVRAL FDFNGNDEED
160 170 180 190 200
LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL
210 220 230 240 250
IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA RVIQKRVPNA
260 270 280 290 300
YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD
EDFS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY902336 Genomic DNA Translation: AAX90621.1 AK154987 mRNA Translation: BAE32976.1 AK161761 mRNA Translation: BAE36562.1 |
RefSeqi | NP_598417.2, NM_133656.5 |
Genome annotation databases
GeneIDi | 12928 |
KEGGi | mmu:12928 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY902336 Genomic DNA Translation: AAX90621.1 AK154987 mRNA Translation: BAE32976.1 AK161761 mRNA Translation: BAE36562.1 |
RefSeqi | NP_598417.2, NM_133656.5 |
3D structure databases
SMRi | Q5ND51 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q5ND51 |
Protocols and materials databases
Antibodypediai | 4185, 623 antibodies |
DNASUi | 12928 |
Genome annotation databases
GeneIDi | 12928 |
KEGGi | mmu:12928 |
Organism-specific databases
CTDi | 1398 |
MGIi | MGI:88508, Crk |
Phylogenomic databases
HOGENOMi | CLU_060542_0_1_1 |
OrthoDBi | 1414461at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12928, 2 hits in 52 CRISPR screens |
ChiTaRSi | Crk, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000017776, Expressed in placenta and 310 other tissues |
ExpressionAtlasi | Q5ND51, baseline and differential |
Family and domain databases
CDDi | cd11759, SH3_CRK_C, 1 hit cd11758, SH3_CRK_N, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035458, CRK_SH3_C IPR035457, CRK_SH3_N IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF50044, SSF50044, 2 hits SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5ND51_MOUSE | |
Accessioni | Q5ND51Primary (citable) accession number: Q5ND51 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |