Crk

Functionⁱ

GO - Molecular functionⁱ

cytoskeletal protein binding Source: Ensembl
ephrin receptor binding Source: Ensembl
insulin-like growth factor receptor binding Source: Ensembl
phosphotyrosine residue binding Source: Ensembl
protein self-association Source: Ensembl
protein tyrosine kinase binding Source: Ensembl
scaffold protein binding Source: Ensembl
SH2 domain binding Source: Ensembl
SH3 domain binding Source: Ensembl
signaling adaptor activity Source: Ensembl

GO - Biological processⁱ

actin cytoskeleton organization Source: Ensembl
cellular response to endothelin Source: Ensembl
cellular response to insulin-like growth factor stimulus Source: Ensembl
cellular response to nerve growth factor stimulus Source: Ensembl
cellular response to nitric oxide Source: Ensembl
cellular response to transforming growth factor beta stimulus Source: Ensembl
ephrin receptor signaling pathway Source: Ensembl
negative regulation of cell motility Source: Ensembl
negative regulation of natural killer cell mediated cytotoxicity Source: Ensembl
negative regulation of wound healing Source: Ensembl
positive regulation of smooth muscle cell migration Source: Ensembl
positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
regulation of actin cytoskeleton organization Source: Ensembl
regulation of cell shape Source: Ensembl
regulation of GTPase activity Source: Ensembl
regulation of protein binding Source: Ensembl
regulation of Rac protein signal transduction Source: Ensembl
response to cholecystokinin Source: Ensembl
response to hepatocyte growth factor Source: Ensembl
response to hydrogen peroxide Source: Ensembl
response to yeast Source: Ensembl

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: V-crk sarcoma virus CT10 oncogene-like proteinImported
Gene namesⁱ	Name:CrkImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:88508, Crk
VEuPathDBⁱ	HostDB:ENSMUSG00000017776

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000017776, Expressed in placenta and 316 other tissues

Bgeeⁱ

ENSMUSG00000017776, Expressed in placenta and 316 other tissues

Interactionⁱ

GO - Molecular functionⁱ

cytoskeletal protein binding Source: Ensembl
ephrin receptor binding Source: Ensembl
insulin-like growth factor receptor binding Source: Ensembl
phosphotyrosine residue binding Source: Ensembl
protein self-association Source: Ensembl
protein tyrosine kinase binding Source: Ensembl
scaffold protein binding Source: Ensembl
SH2 domain binding Source: Ensembl
SH3 domain binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	13 – 118	SH2InterPro annotationAdd BLAST	106
Domainⁱ	132 – 192	SH3InterPro annotationAdd BLAST	61
Domainⁱ	235 – 296	SH3InterPro annotationAdd BLAST	62

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	60 – 85	DisorderedSequence analysisAdd BLAST		26
Regionⁱ	201 – 229	DisorderedSequence analysisAdd BLAST		29

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	66 – 82	Pro residuesSequence analysisAdd BLAST		17

Sequence similaritiesⁱ

Belongs to the CRK family.ARBA annotation

Keywords - Domainⁱ

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

HOGENOMⁱ	CLU_060542_0_1_1
Database of Orthologous Groups More...OrthoDBⁱ	1414461at2759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11759, SH3_CRK_C, 1 hit cd11758, SH3_CRK_N, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR035458, CRK_SH3_C IPR035457, CRK_SH3_N IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit
PRINTSⁱ	PR00401, SH2DOMAIN PR00452, SH3DOMAIN
SMARTⁱ	View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 2 hits
SUPFAMⁱ	SSF50044, SSF50044, 2 hits SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5ND51-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS 
        60         70         80         90        100
VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL 
       110        120        130        140        150
LEFYKIHYLD TTTLIEPVAR SRQGSGVILR QEEAEYVRAL FDFNGNDEED 
       160        170        180        190        200
LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL 
       210        220        230        240        250
IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA RVIQKRVPNA 
       260        270        280        290        300
YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD 

EDFS

Length:304

Mass (Da):33,815

Last modified:May 10, 2005 - v1

Checksum:ⁱ5491896FC7A89065

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY902336 Genomic DNA Translation: AAX90621.1 AK154987 mRNA Translation: BAE32976.1 AK161761 mRNA Translation: BAE36562.1
NCBI Reference Sequences More...RefSeqⁱ	NP_598417.2, NM_133656.5

Genome annotation databases

GeneIDⁱ	12928
KEGGⁱ	mmu:12928

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5ND51	Adapter molecule crk	)	MOUSE		304	UniRef100_Q64010
V-crk avian sarcoma virus CT10 oncogene homolog		MUSSI		304
Isoform Crk-I of Adapter molecule crk		MOUSE		204

Protein	Similar proteins		Species	Score	Length	Source
Q5ND51	Adapter molecule crk	)	MOUSE		304	UniRef90_Q64010
Adapter molecule crk		RAT		304
V-crk avian sarcoma virus CT10 oncogene homolog		MUSSI		304
Uncharacterized protein		BOBOX		376
CRK proto-oncogene, adaptor protein		ICTTR		305
+20

Protein	Similar proteins		Species	Score	Length	Source
Q5ND51	Adapter molecule crk	)	HUMAN		304	UniRef50_P46108
Adapter molecule crk	)	MOUSE		304
Adapter molecule crk		RAT		304
adapter molecule crk isoform X1		PHYMC		387
CRK proto-oncogene, adaptor protein		PANTR		304
+102

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY902336 Genomic DNA Translation: AAX90621.1 AK154987 mRNA Translation: BAE32976.1 AK161761 mRNA Translation: BAE36562.1
RefSeqⁱ	NP_598417.2, NM_133656.5

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protocols and materials databases

Antibodypediaⁱ	4185, 642 antibodies from 38 providers
The DNASU plasmid repository More...DNASUⁱ	12928

Genome annotation databases

GeneIDⁱ	12928
KEGGⁱ	mmu:12928

Organism-specific databases

CTDⁱ	1398
MGIⁱ	MGI:88508, Crk
VEuPathDBⁱ	HostDB:ENSMUSG00000017776

Phylogenomic databases

HOGENOMⁱ	CLU_060542_0_1_1
OrthoDBⁱ	1414461at2759

Miscellaneous databases

BioGRID-ORCSⁱ	12928, 4 hits in 71 CRISPR screens
ChiTaRSⁱ	Crk, mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000017776, Expressed in placenta and 316 other tissues

Bgeeⁱ

ENSMUSG00000017776, Expressed in placenta and 316 other tissues

Family and domain databases

CDDⁱ	cd11759, SH3_CRK_C, 1 hit cd11758, SH3_CRK_N, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR035458, CRK_SH3_C IPR035457, CRK_SH3_N IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain
Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit
PRINTSⁱ	PR00401, SH2DOMAIN PR00452, SH3DOMAIN
SMARTⁱ	View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 2 hits
SUPFAMⁱ	SSF50044, SSF50044, 2 hits SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 2 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5ND51_MOUSE
Accessionⁱ	Q5ND51Primary (citable) accession number: Q5ND51
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	May 25, 2022
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5ND51 (Q5ND51_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

V-crk sarcoma virus CT10 oncogene-like protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ