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Entry version 117 (13 Feb 2019)
Sequence version 2 (05 Sep 2012)
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Protein

WD repeat-containing protein 81

Gene

Wdr81

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (By similarity). May also be involved in maintenance of normal mitochondrial structure and organization (PubMed:23595742).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 81Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Wdr81Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2681828 Wdr81

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Lysosome, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Brain-specific, conditional knockout mice are born at the expected Mendelian frequency, but most of them die a few hours after birth. If they show no overt brain morphological abnormalities, a neuronal accumulation of SQSTM1 in foci is observed.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1349L → P: Progressive ataxia associated with Purkinje cell death. Retinal thinning due to photoreceptor cell death. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002472451 – 1934WD repeat-containing protein 81Add BLAST1934

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5ND34

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5ND34

PeptideAtlas

More...
PeptideAtlasi
Q5ND34

PRoteomics IDEntifications database

More...
PRIDEi
Q5ND34

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5ND34

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5ND34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, Purkinje cells of cerebellum, retinal photoreceptor cells and spinal cord (at protein level) (PubMed:23595742). In brain, specifically expressed by neuronal cells (at protein level). Detected in a wide range of tissues including intestine, adipose tissue, liver, pancreas, thymus, spleen, kidney, heart, eye, sciatic nerve, and testis (PubMed:21885617, PubMed:23595742, PubMed:28404643).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045374 Expressed in 256 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5ND34 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5ND34 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WDR91; involved in early to late endosome cargo transport. Interacts with BECN1; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes. Interacts with SQSTM1; the interaction is direct and regulates the interaction of SQSTM1 with ubiquitinated proteins. Interacts with MAP1LC3C; recruits MAP1LC3C to ubiquitinated protein aggregates in the aggrephagy process.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
228693, 1 interactor

Protein interaction database and analysis system

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IntActi
Q5ND34, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000134266

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5ND34

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini335 – 612BEACHPROSITE-ProRule annotationAdd BLAST278
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1639 – 1678WD 1Add BLAST40
Repeati1685 – 1725WD 2Add BLAST41
Repeati1777 – 1816WD 3Add BLAST40
Repeati1819 – 1857WD 4Add BLAST39
Repeati1904 – 1934WD 5Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 645Necessary and sufficient for the interaction with SQSTM1By similarityAdd BLAST645

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1146 – 1210Glu-richAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat WDR81 family.Curated

Keywords - Domaini

Repeat, Transit peptide, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1786 Eukaryota
KOG4190 Eukaryota
ENOG410XR4I LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000151039

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154851

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG083542

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5ND34

KEGG Orthology (KO)

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KOi
K17601

Identification of Orthologs from Complete Genome Data

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OMAi
EYPASME

Database of Orthologous Groups

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OrthoDBi
101142at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323353

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06071 Beach, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1540.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR011009 Kinase-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02138 Beach, 1 hit
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01026 Beach, 1 hit
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF56112 SSF56112, 1 hit
SSF81837 SSF81837, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50197 BEACH, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5ND34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQGSRRRKV VLTAGSEGWS PSSGPDMEEL LRSVERDLNI DARQLALAPG
60 70 80 90 100
GTHVVALVST RWLASLRERR LGPCPRAEGL GEAEVRTLLQ RSVQRLPPGW
110 120 130 140 150
TRVEVHGLRK RRLSYPLGGG VPFEEGSCSP ETLTRFMQEV AAQNYRNLWR
160 170 180 190 200
HAYHTYGQPY SHSTAPSALP ALDSIRQALQ RVYGCTFLPV GESIPCLSNV
210 220 230 240 250
RDGPCPSRGS PACPSLLRAE ALLESPEMLY VVHPYVQFSL HDVVTFSPAK
260 270 280 290 300
LTNSQAKVLF LLFRVLRAMD ACHRQGLACG ALSLHHIAVD EKLCSELRLD
310 320 330 340 350
LSAYEMPSED ENQEGSEEKN GTGIKSEKEG EGRTECPTCQ KELRGLVLDW
360 370 380 390 400
VHGRISNFHY LMQLNRLAGR RQGDPNYHPV LPWVVDFTTP YGRFRDLRKS
410 420 430 440 450
KFRLNKGDKQ LDFTYEMTRQ AFVAGGAGSG EPPHVPHHIS DVLSDITYYV
460 470 480 490 500
YKARRTPRSV LCGHVRAQWE PHEYPATMER MQTWTPDECI PEFYTDPSIF
510 520 530 540 550
CSIHPDMPDL DVPAWCSSNQ EFVAAHRALL ESWEVSQDLH HWIDLTFGYK
560 570 580 590 600
LQGKEAVKEK NVCLHLVDAH THLTSYGVVQ LFDQPHPQRL AGSPALAPEP
610 620 630 640 650
PLIPRLLVQP IREATGQEDI SGQLINGAGR LVVEATPCET GWTRDRPGTG
660 670 680 690 700
EDDLEQATEA LDSISLPGKA GDQPGSSSSQ ASPGLLSFSA PSGSRPGRRS
710 720 730 740 750
KAAGLDPGEG EEGKIVLPEG FSPIQALEEL EKVGNFLAKG LGSQLEEPEK
760 770 780 790 800
PHAQPPVHLQ SLFHRDMQVL GVLLAEMVFA TRVRILQPDA PLWVRFEAVR
810 820 830 840 850
GLCIRHSKDI PVSLQPVLDT LLQLSGPKSP MVSKKGKLDP LFEYRPVSQG
860 870 880 890 900
LPPPSPAQLL SPFSSVVPFP PYFPALHKFI LLYQARRVED EVQGRELAFA
910 920 930 940 950
LWQQLGAVLN DITPEGLEIL LPFVLSLMSE EHTAVYTAWY LFEPVAKALG
960 970 980 990 1000
PKNANKYLLK PLIGAYESPC RLHGRFYLYT DCFVAQLVVR LGLQAFLTHL
1010 1020 1030 1040 1050
LPHVLQVLAG VEASQEEGKG LVGTTEDEES ELPVSGPGSC AFGEEIQMDG
1060 1070 1080 1090 1100
QPAASSGLGL PDYRSGVSFH DQADLPDTED FQAGLYVAES PQPQEAEAVS
1110 1120 1130 1140 1150
LGQLSDKSST SEASQGEERG GDDGGAPADK NSVKSGDSSQ DLKQSEGSEE
1160 1170 1180 1190 1200
EEEEEGCVVL EEDQEDEVTG TSELTLSDTM LSMETVVAPG DGRDREEEEE
1210 1220 1230 1240 1250
PLTEQTEGKE QKILLDTACK MVRWLSAKLG PTVASRHVAR NLLRLLTSCY
1260 1270 1280 1290 1300
VGPTRQQFTV SSDDTPPLNA GNIYQKRPVL GDIVSGPVLS CLLHIAYLYG
1310 1320 1330 1340 1350
EPVLTYQYLP YISYLVAPGS NSNPSRLNSR KEAGLLAAVT LTQKIIVYLS
1360 1370 1380 1390 1400
DTTLMDILPR ISHEVLLPVL GFLTSFVTGF PSGAQARTVL CVKTISLIAL
1410 1420 1430 1440 1450
ICLRIGQEMV QQHLSEPVAT FFQVFSHLHE LRQQDLPLDP KGCTEGQLPE
1460 1470 1480 1490 1500
ATFSDGQRRP VDPTLLEELQ KVFTLEMAYT IYVPFSCLLG DIIRKIIPNH
1510 1520 1530 1540 1550
ELVGELAGLY LESMSPSSRN PASMEPTMAS AGPEWDPQSG SCLQDDGHSG
1560 1570 1580 1590 1600
TFGSVLVGNR IQIPDSQPQS PGPLGSLSGV GSSGGLSNRN EDNALKRELP
1610 1620 1630 1640 1650
RSAHGLSGNW LAYWQYEIGV SQQDAHFHFH QIRLQSFPGH TGAVKCVAAL
1660 1670 1680 1690 1700
SSEDFFLSGS KDRTVRLWPL YNYGDGTNET ASRLIYAQHR KSVFYVGQLE
1710 1720 1730 1740 1750
APQYVVSCDG AVHVWDPFTG KTLRTVDPSD SRVPLTAVAV MPAPHTSITM
1760 1770 1780 1790 1800
ASSDSTLRFV DCRKPGLQHE FRLGGGLNPG LVRSLAVSPS GRSVVAGFSS
1810 1820 1830 1840 1850
GFMVLLDTRT GLVLRGWPAH EGDILQIKAV EGSVLISSSS DHSLTVWKEL
1860 1870 1880 1890 1900
EQKPTHHYKS ASDPIHTFDL YGSEVVTGTV ANKIGVCSLL EPPSQATTKL
1910 1920 1930
SSENFRGTLT SLALLPTKRH LLLGSDNGII RLLA
Length:1,934
Mass (Da):211,945
Last modified:September 5, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BE776A85B11C8AB
GO
Isoform 2 (identifier: Q5ND34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1457-1490: Missing.

Note: No experimental confirmation available.
Show »
Length:1,900
Mass (Da):207,991
Checksum:iDE5CA4E6F7A0805A
GO
Isoform 3 (identifier: Q5ND34-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1769-1828: Missing.

Note: No experimental confirmation available.
Show »
Length:1,874
Mass (Da):205,633
Checksum:i4F04CFC9632365A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K4DI77K4DI77_MOUSE
WD repeat-containing protein 81
Wdr81
1,934Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XD87F6XD87_MOUSE
WD repeat-containing protein 81
Wdr81
756Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD21396 differs from that shown. Reason: Erroneous translation. Incomplete prediction of CDS at the C-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0199561457 – 1490Missing in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0199571769 – 1828Missing in isoform 3. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL591496 Genomic DNA No translation available.
AK131146 mRNA Translation: BAD21396.1 Sequence problems.
AK160585 mRNA Translation: BAE35892.1
AK172019 mRNA Translation: BAE42779.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48849.1 [Q5ND34-1]

NCBI Reference Sequences

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RefSeqi
NP_620400.2, NM_138950.2 [Q5ND34-1]
XP_006532611.1, XM_006532548.3 [Q5ND34-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.340378

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000173320; ENSMUSP00000134266; ENSMUSG00000045374 [Q5ND34-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
192652

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:192652

UCSC genome browser

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UCSCi
uc007kdu.2 mouse [Q5ND34-3]
uc011xzj.1 mouse [Q5ND34-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591496 Genomic DNA No translation available.
AK131146 mRNA Translation: BAD21396.1 Sequence problems.
AK160585 mRNA Translation: BAE35892.1
AK172019 mRNA Translation: BAE42779.1
CCDSiCCDS48849.1 [Q5ND34-1]
RefSeqiNP_620400.2, NM_138950.2 [Q5ND34-1]
XP_006532611.1, XM_006532548.3 [Q5ND34-3]
UniGeneiMm.340378

3D structure databases

ProteinModelPortaliQ5ND34
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228693, 1 interactor
IntActiQ5ND34, 1 interactor
STRINGi10090.ENSMUSP00000134266

PTM databases

iPTMnetiQ5ND34
PhosphoSitePlusiQ5ND34

Proteomic databases

jPOSTiQ5ND34
PaxDbiQ5ND34
PeptideAtlasiQ5ND34
PRIDEiQ5ND34

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000173320; ENSMUSP00000134266; ENSMUSG00000045374 [Q5ND34-1]
GeneIDi192652
KEGGimmu:192652
UCSCiuc007kdu.2 mouse [Q5ND34-3]
uc011xzj.1 mouse [Q5ND34-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
124997
MGIiMGI:2681828 Wdr81

Phylogenomic databases

eggNOGiKOG1786 Eukaryota
KOG4190 Eukaryota
ENOG410XR4I LUCA
GeneTreeiENSGT00930000151039
HOGENOMiHOG000154851
HOVERGENiHBG083542
InParanoidiQ5ND34
KOiK17601
OMAiEYPASME
OrthoDBi101142at2759
TreeFamiTF323353

Miscellaneous databases

Protein Ontology

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PROi
PR:Q5ND34

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045374 Expressed in 256 organ(s), highest expression level in embryo
ExpressionAtlasiQ5ND34 baseline and differential
GenevisibleiQ5ND34 MM

Family and domain databases

CDDicd06071 Beach, 1 hit
Gene3Di1.10.1540.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR011009 Kinase-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02138 Beach, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM01026 Beach, 1 hit
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF56112 SSF56112, 1 hit
SSF81837 SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197 BEACH, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR81_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5ND34
Secondary accession number(s): G5E8V0
, Q3TA90, Q3TUS9, Q6KAR1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: September 5, 2012
Last modified: February 13, 2019
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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