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Entry version 108 (02 Jun 2021)
Sequence version 1 (01 Feb 2005)
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Protein

Neuralized-like protein 4

Gene

Neurl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuralized-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Neurl4
Synonyms:Kiaa1787
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921092, Neurl4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002991061 – 1563Neuralized-like protein 4Add BLAST1563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei504PhosphoserineBy similarity1
Modified residuei909PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; undergoes HERC2-dependent 'Lys-48' ubiquitination. This ubiquitination leads to proteasomal degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5NCX5

PRoteomics IDEntifications database

More...
PRIDEi
Q5NCX5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
287386 [Q5NCX5-1]
287387 [Q5NCX5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5NCX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5NCX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000047284, Expressed in cerebellum and 290 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5NCX5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5NCX5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97.

Interacts with the E3 ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3A may be indirect and mediated by HERC2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229809, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q5NCX5, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000053235

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5NCX5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5NCX5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 209NHR 1PROSITE-ProRule annotationAdd BLAST167
Domaini319 – 486NHR 2PROSITE-ProRule annotationAdd BLAST168
Domaini522 – 688NHR 3PROSITE-ProRule annotationAdd BLAST167
Domaini718 – 886NHR 4PROSITE-ProRule annotationAdd BLAST169
Domaini915 – 1087NHR 5PROSITE-ProRule annotationAdd BLAST173
Domaini1132 – 1295NHR 6PROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni692 – 717DisorderedSequence analysisAdd BLAST26
Regioni1087 – 1121DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi699 – 716Polar residuesSequence analysisAdd BLAST18
Compositional biasi1090 – 1105Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4625, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159866

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002040_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5NCX5

Database of Orthologous Groups

More...
OrthoDBi
74097at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5NCX5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR037962, Neuralized
IPR006573, NHR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12429, PTHR12429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07177, Neuralized, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00588, NEUZ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51065, NHR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5NCX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGSGGSGG SGAGPGPGPG PGGGGGPGSS GPGLGSGGGL GGGGELHPRT
60 70 80 90 100
GRLVSLSACG RTARRQQPGQ EFNHGLVLSR EPLRDGRVFT VRIDRKVNSW
110 120 130 140 150
SGSIEIGVTA LDPSVLDFPS SATGLKGGSW VVSGCSVLRD GRSVLEEYGQ
160 170 180 190 200
DLDQLVEGDR VGVERTATGE LRLWVNGRDC GVAATGLPAR VWAVVDLYGK
210 220 230 240 250
CTQITVLPSE PGFSPPTPVP TPPLEPLAPP EDSALLEQGT SVDEAFMVSP
260 270 280 290 300
AQARPETFPN SLDSHNDFAS MELSEVVSNA ILSAYNGGLL NVSLSSPPAG
310 320 330 340 350
DGLASSGPAT SPILTSNDAL LFHEKCGTLI KLSNNNKTAE RRRPLDEFNN
360 370 380 390 400
GVVMTNRPLR DNEMFEIRID KLVDKWSGSI EIGVTTHNPN SLEYPATMTN
410 420 430 440 450
LQSGTIMMSG CGILTNGKGT RREYCEFSLD ELQEGDHIGL TRKSNSALHF
460 470 480 490 500
FINGIDQGVA TPLTPPVVYG VVDLYGMAVK VTIVHNNNHS DRLRRNNAIL
510 520 530 540 550
RALSPEGALR RAAPAAQAEP ERLLFHPNCG QKAAITHEGR TALRPHATDD
560 570 580 590 600
FNHGVVLSSR ALRDGEVFQV RIDKMVDKWA GSIEIGVTTH NPAYLQLPST
610 620 630 640 650
MTNLRSGTWM MTGNGVMHNG TTILDEYGHN LDRLKAGDTV GVVRREDGTL
660 670 680 690 700
HFFVNGMTQG PAAWNVPPGV YAVVDLYGQA AQATIVDDVE VPPVSEPLPE
710 720 730 740 750
GNNQMSPSSP SSAAGGSDLR FHQLHGSNAV ITNGGRTALR HNCRSEFNDA
760 770 780 790 800
IVISNRALRD GELFEIVIQK MVDRWSGSIE AGVTAIRPED LEFPNTMTDI
810 820 830 840 850
DYDTWMLSGT AIMQDGNTMR NNYGCDLDAL GTGARIGMMR TAKGDLHYFI
860 870 880 890 900
NGQDQGAACS GLPPGKEVYA VVDLYGQCVQ VSITNATGPM DNSLATSNTA
910 920 930 940 950
TEKSFPLHSP VAGVAHRFHS MCGKNVTLEE DGTRAVRVAG YAHGLVFSTK
960 970 980 990 1000
ELKAEEVFEV KVEELDEKWA GSLRLGLTTL APEDMGPGAG SGPGLPPSLP
1010 1020 1030 1040 1050
ELRTKTTWMV SSCEVRRDGH LQRMNYGRNL ERLGVGSRVG IRRCADDTMH
1060 1070 1080 1090 1100
ILVDGEDMGP AAAGIAKNVW AVLDLYGPVR SVAIVSSTRL EEPEGTQPPS
1110 1120 1130 1140 1150
PSSDTGSEVE EDDEVEEQGL RGQNQVGIVP TALEFLENHG KNILLSNGNR
1160 1170 1180 1190 1200
TATRVASYNQ GIVVISQPLV PHMLVQVRID FLNRQWTSSL VLGVITCPPE
1210 1220 1230 1240 1250
RLNFPASACA LKRAAWLLRG RGVFHNGLKI CEKFGPNLDT CPEGTILGLR
1260 1270 1280 1290 1300
LDSSGGLHLH INGVDQGVAV PDVPQPCHAL VDLYGQCEQV TIVSPDPGTA
1310 1320 1330 1340 1350
SGKIAGTQGD MEKADMVDGI KESVCWGPPP AASPLKSCEY HALCSRFQEL
1360 1370 1380 1390 1400
LLLPEDYFMP PPKRSLCYCE SCRKLRGDEA HRRRGEPPRE YALPFGWCRF
1410 1420 1430 1440 1450
NLRVNPHLEA GTLTKKWHMA YHGSSVAVVR RVLDRGELGA GTTSILSCRP
1460 1470 1480 1490 1500
LKGEPGVGFE EPGENCAPPR EEQPPPVLLS PSLQYAGAEM LASKVQFRDP
1510 1520 1530 1540 1550
KSQRTHQAQV AFQVCVRPGS YTPGPPSAAL RELPDQHFSP SELEWVTKEK
1560
GATLLYALLV RVE
Length:1,563
Mass (Da):167,637
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65F86EC95429B6C0
GO
Isoform 2 (identifier: Q5NCX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-266: Missing.

Show »
Length:1,541
Mass (Da):165,239
Checksum:i08AA3BAF649E8C72
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BK72H3BK72_MOUSE
Neuralized-like protein 4
Neurl4
1,539Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJZ3H3BJZ3_MOUSE
Neuralized-like protein 4
Neurl4
1,561Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9H9T3H9H9T3_MOUSE
Neuralized-like protein 4
Neurl4
972Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WND1F6WND1_MOUSE
Neuralized-like protein 4
Neurl4
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLC3H3BLC3_MOUSE
Neuralized-like protein 4
Neurl4
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI35150 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1247L → M in BAE33965 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027564245 – 266Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL596185 Genomic DNA Translation: CAI35149.1
AL596185 Genomic DNA Translation: CAI35150.1 Sequence problems.
AK157107 mRNA Translation: BAE33965.1
AK173264 mRNA Translation: BAD32542.1
BC023037 mRNA Translation: AAH23037.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24921.1 [Q5NCX5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001013432.1, NM_001013414.3 [Q5NCX5-1]
NP_001278047.1, NM_001291118.1
NP_001278048.1, NM_001291119.1
XP_017169947.1, XM_017314458.1 [Q5NCX5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061837; ENSMUSP00000053235; ENSMUSG00000047284 [Q5NCX5-1]
ENSMUST00000108617; ENSMUSP00000104257; ENSMUSG00000047284 [Q5NCX5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
216860

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:216860

UCSC genome browser

More...
UCSCi
uc007jsn.3, mouse [Q5NCX5-1]
uc011xxf.2, mouse [Q5NCX5-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596185 Genomic DNA Translation: CAI35149.1
AL596185 Genomic DNA Translation: CAI35150.1 Sequence problems.
AK157107 mRNA Translation: BAE33965.1
AK173264 mRNA Translation: BAD32542.1
BC023037 mRNA Translation: AAH23037.1
CCDSiCCDS24921.1 [Q5NCX5-1]
RefSeqiNP_001013432.1, NM_001013414.3 [Q5NCX5-1]
NP_001278047.1, NM_001291118.1
NP_001278048.1, NM_001291119.1
XP_017169947.1, XM_017314458.1 [Q5NCX5-2]

3D structure databases

SMRiQ5NCX5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229809, 8 interactors
IntActiQ5NCX5, 4 interactors
STRINGi10090.ENSMUSP00000053235

PTM databases

iPTMnetiQ5NCX5
PhosphoSitePlusiQ5NCX5

Proteomic databases

PaxDbiQ5NCX5
PRIDEiQ5NCX5
ProteomicsDBi287386 [Q5NCX5-1]
287387 [Q5NCX5-2]

Genome annotation databases

EnsembliENSMUST00000061837; ENSMUSP00000053235; ENSMUSG00000047284 [Q5NCX5-1]
ENSMUST00000108617; ENSMUSP00000104257; ENSMUSG00000047284 [Q5NCX5-2]
GeneIDi216860
KEGGimmu:216860
UCSCiuc007jsn.3, mouse [Q5NCX5-1]
uc011xxf.2, mouse [Q5NCX5-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84461
MGIiMGI:1921092, Neurl4

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG4625, Eukaryota
GeneTreeiENSGT00940000159866
HOGENOMiCLU_002040_1_0_1
InParanoidiQ5NCX5
OrthoDBi74097at2759
PhylomeDBiQ5NCX5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
216860, 1 hit in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Neurl4, mouse

Protein Ontology

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PROi
PR:Q5NCX5
RNActiQ5NCX5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000047284, Expressed in cerebellum and 290 other tissues
ExpressionAtlasiQ5NCX5, baseline and differential
GenevisibleiQ5NCX5, MM

Family and domain databases

Gene3Di2.60.120.920, 6 hits
InterProiView protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR037962, Neuralized
IPR006573, NHR_dom
PANTHERiPTHR12429, PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177, Neuralized, 6 hits
SMARTiView protein in SMART
SM00588, NEUZ, 6 hits
SUPFAMiSSF49899, SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51065, NHR, 6 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEUL4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5NCX5
Secondary accession number(s): Q3U090
, Q5NCX4, Q69ZA2, Q8R1V5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 1, 2005
Last modified: June 2, 2021
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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