UniProtKB - Q5NCU4 (Q5NCU4_MOUSE)
Protein
Osteonectin
Gene
Sparc
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
- collagen binding Source: InterPro
Keywordsi
Ligand | CopperARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: OsteonectinARBA annotationAlternative name(s): SPARCARBA annotation Secreted protein acidic and rich in cysteineARBA annotation |
Gene namesi | Name:SparcImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98373, Sparc |
Subcellular locationi
Extracellular region or secreted
- basement membrane ARBA annotation
Other locations
- Membrane ARBA annotation
Extracellular region or secreted
- basement membrane Source: UniProtKB-SubCell
- extracellular space Source: InterPro
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Basement membraneARBA annotation, Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5004260298 | 18 – 301 | OsteonectinSequence analysisAdd BLAST | 284 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 70 ↔ 81 | UniRule annotation | ||
Disulfide bondi | 75 ↔ 91 | UniRule annotation | ||
Disulfide bondi | 93 ↔ 128 | UniRule annotation | ||
Disulfide bondi | 99 ↔ 121 | UniRule annotation | ||
Disulfide bondi | 110 ↔ 147 | UniRule annotation | ||
Disulfide bondi | 153 ↔ 263 | UniRule annotation | ||
Disulfide bondi | 271 ↔ 287 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotation, GlycoproteinARBA annotationProteomic databases
EPDi | Q5NCU4 |
jPOSTi | Q5NCU4 |
MaxQBi | Q5NCU4 |
PRIDEi | Q5NCU4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000018593, Expressed in vault of skull and 342 other tissues |
ExpressionAtlasi | Q5NCU4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 92 – 149 | Kazal-likeInterPro annotationAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the SPARC family.ARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00510000046787 |
HOGENOMi | CLU_047416_0_0_1 |
OMAi | LVEWGAC |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001999, Osteonectin_CS IPR037641, SPARC IPR019577, SPARC/Testican_Ca-bd-dom |
PANTHERi | PTHR13866:SF6, PTHR13866:SF6, 1 hit |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF00050, Kazal_1, 1 hit PF10591, SPARC_Ca_bdg, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS51465, KAZAL_2, 1 hit PS00612, OSTEONECTIN_1, 1 hit PS00613, OSTEONECTIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q5NCU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAWIFFLLC LAGRALAAPQ TEVAEEIVEE ETVVEETGVP VGANPVQVEM
60 70 80 90 100
GEFEDGAEET VEEVVADNPC QNHHCKHGKV CELDESNTPM CVCQDPTSCP
110 120 130 140 150
APIGEFEKVC SNDNKTFDSS CHFFATKCTL EGTKKGHKLH LDYIGPCKYI
160 170 180 190 200
APCLDSELTE FPLRMRDWLK NVLVTLYERD EGNNLLTEKQ KLRVKKIHEN
210 220 230 240 250
EKRLEAGDHP VELLARDFEK NYNMYIFPVH WQFGQLDQHP IDGYLSHTEL
260 270 280 290 300
APLRAPLIPM EHCTTRFFET CDLDNDKYIA LEEWAGCFGI KEQDINKDLV
I
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP07214 | SPRC_MOUSE | SPARC | Sparc | 302 | Annotation score: | ||
A0A1L1SSH9 | A0A1L1SSH9_MOUSE | Osteonectin | Sparc | 332 | Annotation score: | ||
Q5NCU3 | Q5NCU3_MOUSE | Osteonectin | Sparc | 172 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596207 Genomic DNA No translation available. AL772268 Genomic DNA No translation available. |
RefSeqi | NP_001277746.1, NM_001290817.1 |
Genome annotation databases
Ensembli | ENSMUST00000108858; ENSMUSP00000104486; ENSMUSG00000018593 |
GeneIDi | 20692 |
UCSCi | uc007izi.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596207 Genomic DNA No translation available. AL772268 Genomic DNA No translation available. |
RefSeqi | NP_001277746.1, NM_001290817.1 |
3D structure databases
SMRi | Q5NCU4 |
ModBasei | Search... |
Proteomic databases
EPDi | Q5NCU4 |
jPOSTi | Q5NCU4 |
MaxQBi | Q5NCU4 |
PRIDEi | Q5NCU4 |
Protocols and materials databases
Antibodypediai | 878, 758 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000108858; ENSMUSP00000104486; ENSMUSG00000018593 |
GeneIDi | 20692 |
UCSCi | uc007izi.3, mouse |
Organism-specific databases
CTDi | 6678 |
MGIi | MGI:98373, Sparc |
Phylogenomic databases
GeneTreei | ENSGT00510000046787 |
HOGENOMi | CLU_047416_0_0_1 |
OMAi | LVEWGAC |
Miscellaneous databases
BioGRID-ORCSi | 20692, 1 hit in 19 CRISPR screens |
ChiTaRSi | Sparc, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018593, Expressed in vault of skull and 342 other tissues |
ExpressionAtlasi | Q5NCU4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001999, Osteonectin_CS IPR037641, SPARC IPR019577, SPARC/Testican_Ca-bd-dom |
PANTHERi | PTHR13866:SF6, PTHR13866:SF6, 1 hit |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF00050, Kazal_1, 1 hit PF10591, SPARC_Ca_bdg, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS51465, KAZAL_2, 1 hit PS00612, OSTEONECTIN_1, 1 hit PS00613, OSTEONECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5NCU4_MOUSE | |
Accessioni | Q5NCU4Primary (citable) accession number: Q5NCU4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | February 10, 2021 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |