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Protein

Nuclear speckle splicing regulatory protein 1

Gene

Nsrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that mediates pre-mRNA alternative splicing regulation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear speckle splicing regulatory protein 1
Alternative name(s):
Coiled-coil domain-containing protein 55
Nuclear speckle-related protein 70
Short name:
NSrp70
Gene namesi
Name:Nsrp1
Synonyms:Ccdc55, Nsrp70
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144305 Nsrp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show early embryonic lethality shortly after implantation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404351 – 542Nuclear speckle splicing regulatory protein 1Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei254PhosphoserineCombined sources1
Modified residuei255PhosphoserineBy similarity1
Modified residuei277N6-acetyllysineCombined sources1
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei443PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5NCR9
MaxQBiQ5NCR9
PaxDbiQ5NCR9
PeptideAtlasiQ5NCR9
PRIDEiQ5NCR9

PTM databases

iPTMnetiQ5NCR9
PhosphoSitePlusiQ5NCR9

Expressioni

Gene expression databases

BgeeiENSMUSG00000037958 Expressed in 239 organ(s), highest expression level in embryo
CleanExiMM_CCDC55
ExpressionAtlasiQ5NCR9 baseline and differential
GenevisibleiQ5NCR9 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with SRSF1. Interacts (via C-terminus) with SRSF2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099552

Structurei

3D structure databases

SMRiQ5NCR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 169Necessary for alternative splicing activityBy similarityAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili103 – 172Sequence analysisAdd BLAST70
Coiled coili372 – 413Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 352His-richAdd BLAST75

Sequence similaritiesi

Belongs to the NSRP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2117 Eukaryota
ENOG410Z5A1 LUCA
GeneTreeiENSGT00730000111127
HOVERGENiHBG081043
InParanoidiQ5NCR9
KOiK13206
OMAiDQRERND
OrthoDBiEOG091G0KUG
PhylomeDBiQ5NCR9
TreeFamiTF319359

Family and domain databases

InterProiView protein in InterPro
IPR018612 DUF2040
PfamiView protein in Pfam
PF09745 DUF2040, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5NCR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIPGRQYGL ILPKKTQPLH RVLQKPSVFG SDSDDDETSV SESLQREAAK
60 70 80 90 100
KQAMKQTKLE IQKALAEDST VYEYDSVYDE MQKKKEENNP KLLPGKDRKP
110 120 130 140 150
KYIHNLLKAV EIRKKEQEKR MEKKIQRERE MENGEFDDKE AFVTSAYKKK
160 170 180 190 200
LEERAEEEER EKRAAALEAH LDVTKQKDLS GFYRHLLNQA VGEEAAPKSS
210 220 230 240 250
FREARTVIKE EKLRGYPDET NSESRPPQQS CVLQRGAQEA EENPDADREF
260 270 280 290 300
DDESSEDGEK RDHKVKSRGE DTGASMKHPK HHKNRAHSRS SSEERGLGTK
310 320 330 340 350
HHSRGSQSRG HEHQDRQSRD QESCHKDRSH REEKSSHRHR EASHKDHYWK
360 370 380 390 400
KHEQEDKLKG REQEERQDRE GKREKYSSRE QERDRQRNDH DRYSEKEKKR
410 420 430 440 450
KEKEEHTKAR RERCEDSGKH REREKPEGHG QSSERHRDRR ESSPRSRPKD
460 470 480 490 500
DLDQERSSKA RNTEKDKGEQ GKPSHSETSL ATKHRLAEER PEKGSEQERP
510 520 530 540
PEAVSKFAKR SNEETVMSAR DRYLARQMAR INAKTYIEKE DD
Length:542
Mass (Da):63,799
Last modified:February 1, 2005 - v1
Checksum:iCF97836AEDB0F721
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5NCR8Q5NCR8_MOUSE
Nuclear speckle-splicing regulatory...
Nsrp1 Ccdc55
78Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK168573 mRNA Translation: BAE40443.1
AL603842 Genomic DNA No translation available.
BC089560 mRNA Translation: AAH89560.1
CCDSiCCDS25075.1
RefSeqiNP_001012309.1, NM_001012309.2
UniGeneiMm.156195

Genome annotation databases

EnsembliENSMUST00000102494; ENSMUSP00000099552; ENSMUSG00000037958
GeneIDi237859
KEGGimmu:237859
UCSCiuc007kgg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK168573 mRNA Translation: BAE40443.1
AL603842 Genomic DNA No translation available.
BC089560 mRNA Translation: AAH89560.1
CCDSiCCDS25075.1
RefSeqiNP_001012309.1, NM_001012309.2
UniGeneiMm.156195

3D structure databases

SMRiQ5NCR9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099552

PTM databases

iPTMnetiQ5NCR9
PhosphoSitePlusiQ5NCR9

Proteomic databases

EPDiQ5NCR9
MaxQBiQ5NCR9
PaxDbiQ5NCR9
PeptideAtlasiQ5NCR9
PRIDEiQ5NCR9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102494; ENSMUSP00000099552; ENSMUSG00000037958
GeneIDi237859
KEGGimmu:237859
UCSCiuc007kgg.2 mouse

Organism-specific databases

CTDi84081
MGIiMGI:2144305 Nsrp1

Phylogenomic databases

eggNOGiKOG2117 Eukaryota
ENOG410Z5A1 LUCA
GeneTreeiENSGT00730000111127
HOVERGENiHBG081043
InParanoidiQ5NCR9
KOiK13206
OMAiDQRERND
OrthoDBiEOG091G0KUG
PhylomeDBiQ5NCR9
TreeFamiTF319359

Miscellaneous databases

ChiTaRSiCcdc25 mouse
PROiPR:Q5NCR9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037958 Expressed in 239 organ(s), highest expression level in embryo
CleanExiMM_CCDC55
ExpressionAtlasiQ5NCR9 baseline and differential
GenevisibleiQ5NCR9 MM

Family and domain databases

InterProiView protein in InterPro
IPR018612 DUF2040
PfamiView protein in Pfam
PF09745 DUF2040, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNSRP1_MOUSE
AccessioniPrimary (citable) accession number: Q5NCR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 1, 2005
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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