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Protein

Magnesium transporter MRS2 homolog, mitochondrial

Gene

Mrs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits.By similarity

GO - Molecular functioni

GO - Biological processi

  • magnesium ion transport Source: GO_Central
  • mitochondrial magnesium ion transmembrane transport Source: UniProtKB

Keywordsi

Biological processIon transport, Transport
LigandMagnesium

Enzyme and pathway databases

ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter MRS2 homolog, mitochondrial
Alternative name(s):
MRS2-like protein
Gene namesi
Name:Mrs2
Synonyms:Gm902, Mrs2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2685748 Mrs2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini54 – 328Mitochondrial matrixSequence analysisAdd BLAST275
Transmembranei329 – 351HelicalSequence analysisAdd BLAST23
Topological domaini352 – 363Mitochondrial intermembraneSequence analysisAdd BLAST12
Transmembranei364 – 381HelicalSequence analysisAdd BLAST18
Topological domaini382 – 434Mitochondrial matrixSequence analysisAdd BLAST53

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 53MitochondrionSequence analysisAdd BLAST53
ChainiPRO_000004283954 – 434Magnesium transporter MRS2 homolog, mitochondrialAdd BLAST381

Proteomic databases

MaxQBiQ5NCE8
PaxDbiQ5NCE8
PeptideAtlasiQ5NCE8
PRIDEiQ5NCE8

PTM databases

PhosphoSitePlusiQ5NCE8

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000021339 Expressed in 212 organ(s), highest expression level in oocyte
GenevisibleiQ5NCE8 MM

Interactioni

Protein-protein interaction databases

BioGridi237667, 1 interactor
STRINGi10090.ENSMUSP00000021772

Structurei

3D structure databases

ProteinModelPortaliQ5NCE8
SMRiQ5NCE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS94 Eukaryota
ENOG410XRIZ LUCA
GeneTreeiENSGT00390000009988
HOGENOMiHOG000013083
HOVERGENiHBG103267
InParanoidiQ5NCE8
KOiK16075
OMAiYHLEHNL
OrthoDBiEOG091G094B
PhylomeDBiQ5NCE8
TreeFamiTF328433

Family and domain databases

CDDicd12823 Mrs2_Mfm1p-like, 1 hit
InterProiView protein in InterPro
IPR039204 MRS2-like
PANTHERiPTHR13890 PTHR13890, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NCE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECLRCLPGL LPRAAQPRRA LWTAVARLSL AACGGRATPL RSRSPKASST
60 70 80 90 100
ARAAGDVLRF RTSDASQATL ASVAQVFAVT KFDKEGNVTS FERKKTELYH
110 120 130 140 150
ELALQARDLR FQHVMSITTR NNRIIMRMEY LKAVITPECL LILDYRNLNL
160 170 180 190 200
EHWLFRELPS QLAGEGQLVT YPLPFEFRAI EALLQYWIST LRGRLSVLQP
210 220 230 240 250
LILETLDALV DPKHSSVDRS KLHVLLQNGK SLSELETDIK IFKESILELL
260 270 280 290 300
DEEEMLEELC LTKWSDPHVF EKSSTGIDHA EEMELLLENY YRLAEDLSNE
310 320 330 340 350
ARELRVLIDD SQSIIFINLD SHRNVMMRLN LQLTMGTFSL SLFGLMGVAF
360 370 380 390 400
GMNLESSLEE DHRVFWLVTG IMFMGSGLIW RRLLSFLGRQ LEAPVPPVMT
410 420 430
SLPKKTLLAN RRMDVKNSLR PEGLGASRTI LASR
Length:434
Mass (Da):49,299
Last modified:November 22, 2005 - v2
Checksum:i38A4DD0088B82643
GO

Sequence cautioni

The sequence CAI35077 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645533 Genomic DNA Translation: CAI35077.1 Different initiation.
CCDSiCCDS26385.2
RefSeqiNP_001013407.2, NM_001013389.2
UniGeneiMm.387097

Genome annotation databases

EnsembliENSMUST00000021772; ENSMUSP00000021772; ENSMUSG00000021339
GeneIDi380836
KEGGimmu:380836
UCSCiuc056ytg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645533 Genomic DNA Translation: CAI35077.1 Different initiation.
CCDSiCCDS26385.2
RefSeqiNP_001013407.2, NM_001013389.2
UniGeneiMm.387097

3D structure databases

ProteinModelPortaliQ5NCE8
SMRiQ5NCE8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237667, 1 interactor
STRINGi10090.ENSMUSP00000021772

PTM databases

PhosphoSitePlusiQ5NCE8

Proteomic databases

MaxQBiQ5NCE8
PaxDbiQ5NCE8
PeptideAtlasiQ5NCE8
PRIDEiQ5NCE8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021772; ENSMUSP00000021772; ENSMUSG00000021339
GeneIDi380836
KEGGimmu:380836
UCSCiuc056ytg.1 mouse

Organism-specific databases

CTDi57380
MGIiMGI:2685748 Mrs2

Phylogenomic databases

eggNOGiENOG410IS94 Eukaryota
ENOG410XRIZ LUCA
GeneTreeiENSGT00390000009988
HOGENOMiHOG000013083
HOVERGENiHBG103267
InParanoidiQ5NCE8
KOiK16075
OMAiYHLEHNL
OrthoDBiEOG091G094B
PhylomeDBiQ5NCE8
TreeFamiTF328433

Enzyme and pathway databases

ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

Miscellaneous databases

PROiPR:Q5NCE8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021339 Expressed in 212 organ(s), highest expression level in oocyte
GenevisibleiQ5NCE8 MM

Family and domain databases

CDDicd12823 Mrs2_Mfm1p-like, 1 hit
InterProiView protein in InterPro
IPR039204 MRS2-like
PANTHERiPTHR13890 PTHR13890, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMRS2_MOUSE
AccessioniPrimary (citable) accession number: Q5NCE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 7, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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