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Protein

E3 ubiquitin-protein ligase TRIM41

Gene

Trim41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 61RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM41 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM41Curated
Tripartite motif-containing protein 41
Gene namesi
Name:Trim41
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2384814 Trim41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003866431 – 630E3 ubiquitin-protein ligase TRIM41Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphothreonineBy similarity1
Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei447PhosphoserineBy similarity1

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ5NCC3
PaxDbiQ5NCC3
PeptideAtlasiQ5NCC3
PRIDEiQ5NCC3

PTM databases

iPTMnetiQ5NCC3
PhosphoSitePlusiQ5NCC3

Expressioni

Gene expression databases

BgeeiENSMUSG00000040365 Expressed in 286 organ(s), highest expression level in placenta
ExpressionAtlasiQ5NCC3 baseline and differential
GenevisibleiQ5NCC3 MM

Interactioni

Subunit structurei

Interacts with PRKCA. Interacts with NOD2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5NCC3, 1 interactor
STRINGi10090.ENSMUSP00000037055

Structurei

3D structure databases

ProteinModelPortaliQ5NCC3
SMRiQ5NCC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini413 – 630B30.2/SPRYPROSITE-ProRule annotationAdd BLAST218

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili281 – 374Sequence analysisAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 164Glu-richAdd BLAST114
Compositional biasi172 – 177Poly-Pro6

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 61RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000234133
InParanoidiQ5NCC3
KOiK12017
OMAiWTSGMGG
OrthoDBiEOG091G04RX
PhylomeDBiQ5NCC3
TreeFamiTF342569

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q5NCC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG
60 70 80 90 100
EDEEDRDELD REEEEEEVGE EEEVEAVGAG GGWDTPMREE DYEGDMEEEA
110 120 130 140 150
EEEEEVFWSS GIGGSNWDNM DYVWEEEEEE EEEELDYYLG DVADLRGEDE
160 170 180 190 200
DEEEEVLEED EEEELDPITQ LPPPPAPRRC FTCPQCRKSF PRRSFRPNLQ
210 220 230 240 250
LANMVQVIRQ MHPTPGRGSR VNEQGICPRH QEALKLFCEV DEEAICVVCR
260 270 280 290 300
ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT
310 320 330 340 350
ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA
360 370 380 390 400
NRLEEQAAQL SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EIQLQPPEIW
410 420 430 440 450
SPDPCQPHSH DFLTDAIVRK MSRMFCQAAR VDLTLDPDTA HPALLLSPDR
460 470 480 490 500
RGVRLAERRQ EVPEHSKRFS ADCCVLGAQG FRSGRHYWEV EVGGRRGWAV
510 520 530 540 550
GAARESTHHK EKVGSGGSSV SSGDASSSRH HHRRRRLHLP QQLLLQREVW
560 570 580 590 600
CVGTHGKRYQ AQSSTEQTLL SPCEKPRRFG VYLDYEAGRL GFYNADTLAH
610 620 630
VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP
Length:630
Mass (Da):71,818
Last modified:February 1, 2005 - v1
Checksum:i3CAD7D459DF882DE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5NCC2Q5NCC2_MOUSE
E3 ubiquitin-protein ligase TRIM41
Trim41
161Annotation score:
F6X2H0F6X2H0_MOUSE
E3 ubiquitin-protein ligase TRIM41
Trim41
157Annotation score:
Q5NCC4Q5NCC4_MOUSE
E3 ubiquitin-protein ligase TRIM41
Trim41
126Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645849 Genomic DNA Translation: CAI35108.1
CH466575 Genomic DNA Translation: EDL33789.1
CCDSiCCDS36138.1
RefSeqiNP_663352.2, NM_145377.2
UniGeneiMm.794

Genome annotation databases

EnsembliENSMUST00000047145; ENSMUSP00000037055; ENSMUSG00000040365
GeneIDi211007
KEGGimmu:211007
UCSCiuc007ipc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645849 Genomic DNA Translation: CAI35108.1
CH466575 Genomic DNA Translation: EDL33789.1
CCDSiCCDS36138.1
RefSeqiNP_663352.2, NM_145377.2
UniGeneiMm.794

3D structure databases

ProteinModelPortaliQ5NCC3
SMRiQ5NCC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5NCC3, 1 interactor
STRINGi10090.ENSMUSP00000037055

PTM databases

iPTMnetiQ5NCC3
PhosphoSitePlusiQ5NCC3

Proteomic databases

MaxQBiQ5NCC3
PaxDbiQ5NCC3
PeptideAtlasiQ5NCC3
PRIDEiQ5NCC3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047145; ENSMUSP00000037055; ENSMUSG00000040365
GeneIDi211007
KEGGimmu:211007
UCSCiuc007ipc.1 mouse

Organism-specific databases

CTDi90933
MGIiMGI:2384814 Trim41

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000234133
InParanoidiQ5NCC3
KOiK12017
OMAiWTSGMGG
OrthoDBiEOG091G04RX
PhylomeDBiQ5NCC3
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q5NCC3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040365 Expressed in 286 organ(s), highest expression level in placenta
ExpressionAtlasiQ5NCC3 baseline and differential
GenevisibleiQ5NCC3 MM

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI41_MOUSE
AccessioniPrimary (citable) accession number: Q5NCC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 1, 2005
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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