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Protein

Transcription termination factor 2

Gene

Ttf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi572 – 579ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation, Transcription termination
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 2 (EC:3.6.4.-)
Alternative name(s):
RNA polymerase II termination factor
Transcription release factor 2
Gene namesi
Name:Ttf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1921294 Ttf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743771 – 1138Transcription termination factor 2Add BLAST1138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei436PhosphoserineBy similarity1
Modified residuei859PhosphoserineBy similarity1
Modified residuei884PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5NC05
MaxQBiQ5NC05
PaxDbiQ5NC05
PeptideAtlasiQ5NC05
PRIDEiQ5NC05

PTM databases

iPTMnetiQ5NC05
PhosphoSitePlusiQ5NC05

Expressioni

Gene expression databases

BgeeiENSMUSG00000033222 Expressed in 183 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ5NC05 baseline and differential
GenevisibleiQ5NC05 MM

Interactioni

Subunit structurei

Interacts with CDC5L. Part of the spliceosome (By similarity).By similarity

Protein-protein interaction databases

BioGridi216447, 1 interactor
IntActiQ5NC05, 1 interactor
STRINGi10090.ENSMUSP00000076208

Structurei

3D structure databases

ProteinModelPortaliQ5NC05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini559 – 762Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST204
Domaini971 – 1133Helicase C-terminalPROSITE-ProRule annotationAdd BLAST163

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi713 – 716DEAH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Phylogenomic databases

eggNOGiKOG1001 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00910000144263
HOGENOMiHOG000154708
HOVERGENiHBG053179
InParanoidiQ5NC05
KOiK15173
OMAiQWTSMLK
OrthoDBiEOG091G08AX
PhylomeDBiQ5NC05
TreeFamiTF316297

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR010666 Znf_GRF
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
PF06839 zf-GRF, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5NC05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLVKCPEHG DACFLKTGVR DGPNKGKSFY VCRTNTCGFV QATDIPVSHC
60 70 80 90 100
LLHEEFVVEL QGLFLPQDKK EWRLFFRCAR TKAEGKQWCG NVPWRQDPNP
110 120 130 140 150
KELSVTSKPQ QPSESQLHSP SQPRNPFRVL NKNQKTLERK QFVEEGERKT
160 170 180 190 200
ADKKLRENNE QLLDQRKEQK PKSNSRMEKD PSSDLVATRQ SGGDREEQEK
210 220 230 240 250
SKFQPKTKKA EGMASKQGHG EVLQGIPKGP HMSESESRGV PNKPETLREK
260 270 280 290 300
ETQLLVPSVP GQNPESKVQK EGHVSREPLK NGEAPSAQVT QRGLAQGPLQ
310 320 330 340 350
GPSKTWRPVP EAPAAPELCS GMAHHATSSS EDSEDDGVSS RPGSPLLFDS
360 370 380 390 400
TVDSQKKGSL QHSDQSVQRQ MPAASGVSKK GDSSDPAAQR ANLTTQLKQK
410 420 430 440 450
KGTLAAVNIQ ALPDKGEKLL KQIQALEDAL SALALSPEQG TKEKCSAQEP
460 470 480 490 500
EQSNITKAAA APLHLVPPQP LPRPLIQPAS SLGLKAGRQE TPEGASQCSG
510 520 530 540 550
GHMNQHHLYN VWKITSEAID ELHRSLKSCP GETAVAEDPA GLKVPLLLHQ
560 570 580 590 600
KQALAWLLWR ESQKPQGGIL ADDMGLGKTL TMIALILTKK NQQKSKEKER
610 620 630 640 650
SEPVTWLSKN DSSVFTSSGT LIVCPASLIH HWKNEVEKRV TSNRLRIYLY
660 670 680 690 700
HGPNRSRHAK VLSTYDIVIT TYSLLAKEIP TTKQEGEVPG ANLSVEGTSA
710 720 730 740 750
PLLQVVWARI ILDEAHNVKN PRVQTSIAVC KLQAQARWAV TGTPIQNNLL
760 770 780 790 800
DMYSLMKFLR CSPFDEFSLW KSQVDNGSMK GGERLSILTK SLLLRRTKDQ
810 820 830 840 850
LDSTGKPLVA LPARRCQLHR LKLSEDERAV YDIFLARSRS ALQSYLKRQE
860 870 880 890 900
GRGSHHGRSP DNPFSRVAQE FGSSVSQGCP AADSQRPSTV HVLSQLLRLR
910 920 930 940 950
QCCCHLSLLK SALDPTELES EGLVLSLEEQ LSALTLSKVD VSEPSPTVSL
960 970 980 990 1000
NGTCFKAELF DDTRRSTKVS SLLAELEAIQ KGPGSQKSVI VSQWTSMLQV
1010 1020 1030 1040 1050
VALHLKKNRL TYATIDGSVN PKQRMDLVEA FNHSQGPQVM LISLLAGGVG
1060 1070 1080 1090 1100
LNLTGGNHLF LLDMHWNPSL EDQACDRIYR VGQKKDVVIH RFVCEGTVEE
1110 1120 1130
KILQLQEKKK DLAKQVLSGS EGPVTKLTLA DLKILFGI
Length:1,138
Mass (Da):125,530
Last modified:July 10, 2007 - v2
Checksum:iEA46A8F37DECCC56
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RQ10F6RQ10_MOUSE
Transcription termination factor 2
Ttf2
182Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5K → E in AAH87733 (PubMed:15489334).Curated1
Sequence conflicti100P → R in CAI26225 (PubMed:19468303).Curated1
Sequence conflicti175S → C in CAI26225 (PubMed:19468303).Curated1
Sequence conflicti199E → EE in CAI26225 (PubMed:19468303).Curated1
Sequence conflicti208K → E in AAH87733 (PubMed:15489334).Curated1
Sequence conflicti246T → P in CAI26225 (PubMed:19468303).Curated1
Sequence conflicti290 – 292TQR → AQK in CAI26225 (PubMed:19468303).Curated3
Sequence conflicti317E → G in CAI26225 (PubMed:19468303).Curated1
Sequence conflicti355Q → K in CAI26225 (PubMed:19468303).Curated1
Sequence conflicti437 – 438PE → SD in CAI26225 (PubMed:19468303).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669872 Genomic DNA Translation: CAM22070.1
AL669937 Genomic DNA Translation: CAI26225.2
BC087733 mRNA Translation: AAH87733.1
BC096625 mRNA Translation: AAH96625.1
CCDSiCCDS17679.1
RefSeqiNP_001013044.2, NM_001013026.2
UniGeneiMm.270961

Genome annotation databases

EnsembliENSMUST00000076941; ENSMUSP00000076208; ENSMUSG00000033222
GeneIDi74044
KEGGimmu:74044
UCSCiuc008qrb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669872 Genomic DNA Translation: CAM22070.1
AL669937 Genomic DNA Translation: CAI26225.2
BC087733 mRNA Translation: AAH87733.1
BC096625 mRNA Translation: AAH96625.1
CCDSiCCDS17679.1
RefSeqiNP_001013044.2, NM_001013026.2
UniGeneiMm.270961

3D structure databases

ProteinModelPortaliQ5NC05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216447, 1 interactor
IntActiQ5NC05, 1 interactor
STRINGi10090.ENSMUSP00000076208

PTM databases

iPTMnetiQ5NC05
PhosphoSitePlusiQ5NC05

Proteomic databases

EPDiQ5NC05
MaxQBiQ5NC05
PaxDbiQ5NC05
PeptideAtlasiQ5NC05
PRIDEiQ5NC05

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076941; ENSMUSP00000076208; ENSMUSG00000033222
GeneIDi74044
KEGGimmu:74044
UCSCiuc008qrb.2 mouse

Organism-specific databases

CTDi8458
MGIiMGI:1921294 Ttf2

Phylogenomic databases

eggNOGiKOG1001 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00910000144263
HOGENOMiHOG000154708
HOVERGENiHBG053179
InParanoidiQ5NC05
KOiK15173
OMAiQWTSMLK
OrthoDBiEOG091G08AX
PhylomeDBiQ5NC05
TreeFamiTF316297

Miscellaneous databases

PROiPR:Q5NC05
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033222 Expressed in 183 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ5NC05 baseline and differential
GenevisibleiQ5NC05 MM

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR010666 Znf_GRF
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
PF06839 zf-GRF, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTF2_MOUSE
AccessioniPrimary (citable) accession number: Q5NC05
Secondary accession number(s): Q4V9Y7, Q5M924
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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