POZ (BTB) and AT hook-containing zinc finger 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR."
    Bilic I., Koesters C., Unger B., Sekimata M., Hertweck A., Maschek R., Wilson C.B., Ellmeier W.
    Nat Immunol 7:392-400(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR."
    Bilic I., Koesters C., Unger B., Sekimata M., Hertweck A., Maschek R., Wilson C.B., Ellmeier W.
    Nat Immunol 7:392-400(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• male gonad development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "PATZ1 gene has a critical role in the spermatogenesis and testicular tumours."
    Fedele M., Franco R., Salvatore G., Paronetto M.P., Barbagallo F., Pero R., Chiariotti L., Sette C., Tramontano D., Chieffi G., Fusco A., Chieffi P.
    J Pathol 215:39-47(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: MGI <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor."
    Fedele M., Benvenuto G., Pero R., Majello B., Battista S., Lembo F., Vollono E., Day P.M., Santoro M., Lania L., Bruni C.B., Fusco A., Chiatiotti L.
    J. Biol. Chem. 275:7894-7901(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain."
    Kobayashi A., Yamagiwa H., Hoshino H., Muto A., Sato K., Morita M., Hayashi N., Yamamoto M., Igarashi K.
    Mol Cell Biol 20:1733-1746(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: MGIInferred from direct assayⁱ
  • "Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR."
    Bilic I., Koesters C., Unger B., Sekimata M., Hertweck A., Maschek R., Wilson C.B., Ellmeier W.
    Nat Immunol 7:392-400(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR."
    Bilic I., Koesters C., Unger B., Sekimata M., Hertweck A., Maschek R., Wilson C.B., Ellmeier W.
    Nat Immunol 7:392-400(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "PATZ1 gene has a critical role in the spermatogenesis and testicular tumours."
    Fedele M., Franco R., Salvatore G., Paronetto M.P., Barbagallo F., Pero R., Chiariotti L., Sette C., Tramontano D., Chieffi G., Fusco A., Chieffi P.
    J Pathol 215:39-47(2008) [PubMed] [Europe PMC] [Abstract]
• T cell differentiation Source: MGIInferred from direct assayⁱ
  • "Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR."
    Bilic I., Koesters C., Unger B., Sekimata M., Hertweck A., Maschek R., Wilson C.B., Ellmeier W.
    Nat Immunol 7:392-400(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE 
        60         70         80         90        100
SFPAHRAVLA ACSEYFESVF SAQLGDGGAA DGGPADVGGA AAAPGGGAGG 
       110        120        130        140        150
SRELEMHTIS SKVFGDILDF AYTSRIVVRL ESFPELMTAA KFLLMRSVIE 
       160        170        180        190        200
ICQEVIKQSN VQILVPPARA DIMLFRPPGT SDLGFPLDMT NGAAMAANSN 
       210        220        230        240        250
GIAGSMQPEE EAARATGAAI AGQASLPVLP GVDRLPMVAG PLSPQLLTSP 
       260        270        280        290        300
FPNVASSAPP LTSKRGRGRP RKANLLDSMF GSPGGLREAG ILPCGLCGKV 
       310        320        330        340        350
FTDANRLRQH EAQHGVTSLQ LGYIDLPPPR LGENGLPISE DPDGPRKRSR 
       360        370        380        390        400
TRKQVACEIC GKIFRDVYHL NRHKLSHSGE KPYSCPVCGL RFKRKDRMSY 
       410        420        430        440        450
HVRSHDGSVG KPYICQSCGK GFSRPDHLNG HIKQVHTSER PHKCQVWVGS 
       460        470        480        490        500
SSGLPPLEPL PSDLPSWDFA QPALWRSSHS VPDTAFSLSL KKSFPALENL 
       510        520        530 
SPAHSSNALF CSAPPGYLRQ GWTAPEGSLA FTQWPVG               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ