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Entry version 135 (10 Feb 2021)
Sequence version 2 (02 Oct 2007)
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Protein

Ectonucleoside triphosphate diphosphohydrolase 8

Gene

ENTPD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity, Mg2+By similarityNote: Ca2+ or Mg2+. Has lower efficiency with Mg2+.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Not inhibited by ARL 67156.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=81 µM for ATP1 Publication
  2. KM=137 µM for ADP1 Publication
  3. KM=480 µM for UTP1 Publication
  4. KM=241 µM for UDP1 Publication
  1. Vmax=790 nmol/min/mg enzyme with ATP as substrate1 Publication
  2. Vmax=163 nmol/min/mg enzyme with ADP as substrate1 Publication
  3. Vmax=1100 nmol/min/mg enzyme with UTP as substrate1 Publication
  4. Vmax=110 nmol/min/mg enzyme with UDP as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei168Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5MY95

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8850843, Phosphate bond hydrolysis by NTPDase proteins

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q5MY95

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 8 (EC:3.6.1.5)
Short name:
E-NTPDase 8
Short name:
NTPDase 8
Short name:
NTPDase8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENTPD8
ORF Names:UNQ2492/PRO5779
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24860, ENTPD8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616748, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5MY95

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000188833.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 471ExtracellularSequence analysisAdd BLAST442
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 495CytoplasmicSequence analysis3

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
377841

Open Targets

More...
OpenTargetsi
ENSG00000188833

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671906

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5MY95, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5338

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENTPD8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158705943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068821 – 495Ectonucleoside triphosphate diphosphohydrolase 8Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi78 ↔ 102By similarity
Disulfide bondi246 ↔ 292By similarity
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 335By similarity
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi381 ↔ 403By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5MY95

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5MY95

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5MY95

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5MY95

PeptideAtlas

More...
PeptideAtlasi
Q5MY95

PRoteomics IDEntifications database

More...
PRIDEi
Q5MY95

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63592 [Q5MY95-1]
63593 [Q5MY95-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q5MY95, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5MY95

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5MY95

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188833, Expressed in mucosa of transverse colon and 76 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5MY95, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188833, Tissue enriched (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
132022, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q5MY95, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360561

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q5MY95

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5MY95, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5MY95

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembranous domains are involved in regulation of enzyme activity.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1386, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01010000222337

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010246_2_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5MY95

Identification of Orthologs from Complete Genome Data

More...
OMAi
QFYAFSN

Database of Orthologous Groups

More...
OrthoDBi
1337265at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5MY95

TreeFam database of animal gene trees

More...
TreeFami
TF332859

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000407, GDA1_CD39_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR11782, PTHR11782, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01150, GDA1_CD39, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01238, GDA1_CD39_NTPASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5MY95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLSRKEQVF LALLGASGVS GLTALILLLV EATSVLLPTD IKFGIVFDAG
60 70 80 90 100
SSHTSLFLYQ WLANKENGTG VVSQALACQV EGPGISSYTS NAAQAGESLQ
110 120 130 140 150
GCLEEALVLI PEAQHRKTPT FLGATAGMRL LSRKNSSQAR DIFAAVTQVL
160 170 180 190 200
GRSPVDFWGA ELLAGQAEGA FGWITVNYGL GTLVKYSFTG EWIQPPEEML
210 220 230 240 250
VGALDMGGAS TQITFVPGGP ILDKSTQADF RLYGSDYSVY THSYLCFGRD
260 270 280 290 300
QMLSRLLVGL VQSRPAALLR HPCYLSGYQT TLALGPLYES PCVHATPPLS
310 320 330 340 350
LPQNLTVEGT GNPGACVSAI RELFNFSSCQ GQEDCAFDGV YQPPLRGQFY
360 370 380 390 400
AFSNFYYTFH FLNLTSRQPL STVNATIWEF CQRPWKLVEA SYPGQDRWLR
410 420 430 440 450
DYCASGLYIL TLLHEGYGFS EETWPSLEFR KQAGGVDIGW TLGYMLNLTG
460 470 480 490
MIPADAPAQW RAESYGVWVA KVVFMVLALV AVVGAALVQL FWLQD
Length:495
Mass (Da):53,904
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i030200E15F662D82
GO
Isoform 2 (identifier: Q5MY95-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-387: Missing.

Show »
Length:458
Mass (Da):49,393
Checksum:iC2BEDCB65064B6B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5J8H7C5J8_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD8
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03533962L → P4 PublicationsCorresponds to variant dbSNP:rs6606582Ensembl.1
Natural variantiVAR_061385428E → K. Corresponds to variant dbSNP:rs61491031Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028559351 – 387Missing in isoform 2. 2 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY903953 Transcribed RNA Translation: AAW83515.1
AY903954 mRNA Translation: AAW83516.1
AY430414 mRNA Translation: AAR04374.1
AY359088 mRNA Translation: AAQ89446.1
BX322799 Genomic DNA No translation available.
BC141810 mRNA Translation: AAI41811.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43913.1 [Q5MY95-1]
CCDS7043.1 [Q5MY95-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001028285.1, NM_001033113.1 [Q5MY95-1]
NP_940987.2, NM_198585.2 [Q5MY95-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344119; ENSP00000344089; ENSG00000188833 [Q5MY95-2]
ENST00000371506; ENSP00000360561; ENSG00000188833 [Q5MY95-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
377841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:377841

UCSC genome browser

More...
UCSCi
uc004cmw.3, human [Q5MY95-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY903953 Transcribed RNA Translation: AAW83515.1
AY903954 mRNA Translation: AAW83516.1
AY430414 mRNA Translation: AAR04374.1
AY359088 mRNA Translation: AAQ89446.1
BX322799 Genomic DNA No translation available.
BC141810 mRNA Translation: AAI41811.1
CCDSiCCDS43913.1 [Q5MY95-1]
CCDS7043.1 [Q5MY95-2]
RefSeqiNP_001028285.1, NM_001033113.1 [Q5MY95-1]
NP_940987.2, NM_198585.2 [Q5MY95-2]

3D structure databases

SMRiQ5MY95
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi132022, 1 interactor
IntActiQ5MY95, 1 interactor
STRINGi9606.ENSP00000360561

Chemistry databases

BindingDBiQ5MY95
ChEMBLiCHEMBL5338

PTM databases

GlyGeniQ5MY95, 3 sites
iPTMnetiQ5MY95
PhosphoSitePlusiQ5MY95

Genetic variation databases

BioMutaiENTPD8
DMDMi158705943

Proteomic databases

EPDiQ5MY95
jPOSTiQ5MY95
MassIVEiQ5MY95
PaxDbiQ5MY95
PeptideAtlasiQ5MY95
PRIDEiQ5MY95
ProteomicsDBi63592 [Q5MY95-1]
63593 [Q5MY95-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
19016, 147 antibodies

The DNASU plasmid repository

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DNASUi
377841

Genome annotation databases

EnsembliENST00000344119; ENSP00000344089; ENSG00000188833 [Q5MY95-2]
ENST00000371506; ENSP00000360561; ENSG00000188833 [Q5MY95-1]
GeneIDi377841
KEGGihsa:377841
UCSCiuc004cmw.3, human [Q5MY95-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
377841
DisGeNETi377841

GeneCards: human genes, protein and diseases

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GeneCardsi
ENTPD8
HGNCiHGNC:24860, ENTPD8
HPAiENSG00000188833, Tissue enriched (intestine)
MIMi616748, gene
neXtProtiNX_Q5MY95
OpenTargetsiENSG00000188833
PharmGKBiPA142671906
VEuPathDBiHostDB:ENSG00000188833.9

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1386, Eukaryota
GeneTreeiENSGT01010000222337
HOGENOMiCLU_010246_2_3_1
InParanoidiQ5MY95
OMAiQFYAFSN
OrthoDBi1337265at2759
PhylomeDBiQ5MY95
TreeFamiTF332859

Enzyme and pathway databases

PathwayCommonsiQ5MY95
ReactomeiR-HSA-8850843, Phosphate bond hydrolysis by NTPDase proteins
SABIO-RKiQ5MY95

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
377841, 2 hits in 877 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
377841
PharosiQ5MY95, Tbio

Protein Ontology

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PROi
PR:Q5MY95
RNActiQ5MY95, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000188833, Expressed in mucosa of transverse colon and 76 other tissues
ExpressionAtlasiQ5MY95, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000407, GDA1_CD39_NTPase
PANTHERiPTHR11782, PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150, GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238, GDA1_CD39_NTPASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENTP8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5MY95
Secondary accession number(s): A2BG17, Q6UVZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: February 10, 2021
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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