UniProtKB - Q5MP50 (Q5MP50_9ENTO)
Genome polyprotein
Functioni
Acts as a primer for viral RNA replication and remains covalently bound to viral genomic RNA. VPg is uridylylated prior to priming replication into VPg-pUpU (By similarity).
The oriI viral genomic sequence may act as a template for this. The VPg-pUpU is then used as primer on the genomic RNA poly(A) by the RNA-dependent RNA polymerase to replicate the viral genome (By similarity).
Following genome release from the infecting virion in the cytoplasm, the VPg-RNA linkage is probably removed by host TDP2 (By similarity).
During the late stage of the replication cycle, host TDP2 is excluded from sites of viral RNA synthesis and encapsidation, allowing for the generation of progeny virions.
ARBA annotationGO - Molecular functioni
- peptidase activity Source: UniProtKB-KW
- structural molecule activity Source: InterPro
GO - Biological processi
- viral entry into host cell Source: UniProtKB-KW
- virion attachment to host cell Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, ProteaseARBA annotation |
Biological process | Host-virus interaction, Viral attachment to host cellARBA annotation, Virus entry into host cell |
Protein family/group databases
MEROPSi | C03.020 |
Names & Taxonomyi
Protein namesi | Recommended name: Genome polyproteinARBA annotation |
Organismi | Coxsackievirus A9Imported |
Taxonomic identifieri | 12067 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Picornavirales › Picornaviridae › Enterovirus › Enterovirus B |
Subcellular locationi
- Cytoplasm ARBA annotation
- Host cytoplasm ARBA annotation
Keywords - Cellular componenti
Host cytoplasmARBA annotation, VirionStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 39 | RhvInterPro annotationAdd BLAST | 39 | |
Domaini | 143 – 269 | Pico_P2AInterPro annotationAdd BLAST | 127 | |
Domaini | 274 – 373 | Pico_P2BInterPro annotationAdd BLAST | 100 |
Family and domain databases
CDDi | cd00205, rhv_like, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.60.120.20, 1 hit |
InterProi | View protein in InterPro IPR000081, Peptidase_C3 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR002527, Pico_P2B IPR001676, Picornavirus_capsid IPR033703, Rhv-like IPR029053, Viral_coat |
Pfami | View protein in Pfam PF00947, Pico_P2A, 1 hit PF01552, Pico_P2B, 1 hit PF00073, Rhv, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
i Sequence
Sequence statusi: Fragment.
10 20 30 40 50
NAPARMSIPF ISIGNAYSNF YDGWSNFDQK GSYGYNTLNN LGHIYVRHVS
60 70 80 90 100
GSSPHPITST IRIYFKPKHT RAWVPRPPRL CQYKKAFSVD FTPTPITDTR
110 120 130 140 150
KDINTVTTIV QSEHRGDLAV LNTHGAFGHQ SGAIYVGNYK VVNRHLATHA
160 170 180 190 200
DWQNCVWEEY NRDLLISTTT AHGCDTIARC QCTTGVYFCA SKNKHYPVTF
210 220 230 240 250
EGPGLVEVQE SEYYPRRYQS HVLLAAGFSE PGDCGGILRC EHGVIGIVTM
260 270 280 290 300
GGEGVVGFAD VRDLLWLEDD AMEQGVKDYV EQLGNAFGSG FTNQICEQVN
310 320 330 340 350
LLKESLVGQD SILEKSLRAL VKIISALVIV VRNHDDLITV TATLALVGCT
360 370 380 390 400
SSPWRWLKQK VSQYYGIPMA ERQNNGWLKK FTEMTNACKG MEWIAIKIQK
410 420 430 440 450
FIEWLKVKIL PEVKEKHEFL NRLKQLPLLE SQIATIEQSA PSQSDQEQLF
460 470
SNVQYFAHYC RKYAPLYAAE AKRVFSL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 477 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY684138 Genomic RNA Translation: AAT99728.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY684138 Genomic RNA Translation: AAT99728.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | C03.020 |
Family and domain databases
CDDi | cd00205, rhv_like, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.60.120.20, 1 hit |
InterProi | View protein in InterPro IPR000081, Peptidase_C3 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR002527, Pico_P2B IPR001676, Picornavirus_capsid IPR033703, Rhv-like IPR029053, Viral_coat |
Pfami | View protein in Pfam PF00947, Pico_P2A, 1 hit PF01552, Pico_P2B, 1 hit PF00073, Rhv, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5MP50_9ENTO | |
Accessioni | Q5MP50Primary (citable) accession number: Q5MP50 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 1, 2005 |
Last sequence update: | February 1, 2005 | |
Last modified: | May 25, 2022 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |