UniProtKB - Q5MNY4 (IL2RA_MACMU)
Protein
Interleukin-2 receptor subunit alpha
Gene
IL2RA
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.By similarity
GO - Molecular functioni
- interleukin-2 binding Source: GO_Central
- interleukin-2 receptor activity Source: GO_Central
GO - Biological processi
- immune system process Source: UniProtKB-KW
- inflammatory response Source: GO_Central
Keywordsi
Molecular function | Receptor |
Biological process | Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-2 receptor subunit alphaShort name: IL-2 receptor subunit alpha Short name: IL-2-RA Short name: IL-2R subunit alpha Short name: IL2-RA Alternative name(s): CD_antigen: CD25 |
Gene namesi | Name:IL2RA |
Organismi | Macaca mulatta (Rhesus macaque) |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Other locations
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 240 | ExtracellularSequence analysisAdd BLAST | 219 | |
Transmembranei | 241 – 259 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 260 – 272 | CytoplasmicSequence analysisAdd BLAST | 13 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000011025 | 22 – 272 | Interleukin-2 receptor subunit alphaAdd BLAST | 251 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 67 | PROSITE-ProRule annotation | ||
Disulfide bondi | 49 ↔ 80 | PROSITE-ProRule annotation | ||
Disulfide bondi | 51 ↔ 82 | PROSITE-ProRule annotation | ||
Glycosylationi | 70 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 125 ↔ 168 | PROSITE-ProRule annotation | ||
Disulfide bondi | 152 ↔ 184 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).
By similarityGO - Molecular functioni
- interleukin-2 binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000036344 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 84 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 123 – 186 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 64 |
Keywords - Domaini
Repeat, Signal, Sushi, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SUAG, Eukaryota |
InParanoidi | Q5MNY4 |
OrthoDBi | 1236351at2759 |
Family and domain databases
CDDi | cd00033, CCP, 1 hit |
InterProi | View protein in InterPro IPR015486, IL-2_rcpt_alpha IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
PANTHERi | PTHR10573, PTHR10573, 1 hit |
Pfami | View protein in Pfam PF00084, Sushi, 1 hit |
SMARTi | View protein in SMART SM00032, CCP, 2 hits |
SUPFAMi | SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5MNY4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPYLLMWGL LTFITVPGCQ AELCDDDPPK ITHATFKAVA YKEGTMLNCE
60 70 80 90 100
CKRGFRRIKS GSPYMLCTGN SSHSSWDNQC QCTSSAARNT TKQVTPQPEE
110 120 130 140 150
QKERKTTEMQ SQMQLADQVS LPGHCREPPP WENEATERIY HFVVGQMVYY
160 170 180 190 200
QCVQGYRALH RGPAESICKM THGKTRWTQP QLICTGETEP SQFPGEEEPQ
210 220 230 240 250
ASPDGLPESE TSRLVTTTDF RIQTEVAATM ETFIFTTEYQ VAVAGCVFLL
260 270
ISVLLLSGLT WQRRQRKNRR TI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY693777 mRNA Translation: AAV49318.1 |
RefSeqi | NP_001028089.1, NM_001032917.2 |
Genome annotation databases
GeneIDi | 574300 |
KEGGi | mcc:574300 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY693777 mRNA Translation: AAV49318.1 |
RefSeqi | NP_001028089.1, NM_001032917.2 |
3D structure databases
SMRi | Q5MNY4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000036344 |
Genome annotation databases
GeneIDi | 574300 |
KEGGi | mcc:574300 |
Organism-specific databases
CTDi | 3559 |
Phylogenomic databases
eggNOGi | ENOG502SUAG, Eukaryota |
InParanoidi | Q5MNY4 |
OrthoDBi | 1236351at2759 |
Family and domain databases
CDDi | cd00033, CCP, 1 hit |
InterProi | View protein in InterPro IPR015486, IL-2_rcpt_alpha IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
PANTHERi | PTHR10573, PTHR10573, 1 hit |
Pfami | View protein in Pfam PF00084, Sushi, 1 hit |
SMARTi | View protein in SMART SM00032, CCP, 2 hits |
SUPFAMi | SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL2RA_MACMU | |
Accessioni | Q5MNY4Primary (citable) accession number: Q5MNY4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | February 1, 2005 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |