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Protein

Interleukin-2 receptor subunit alpha

Gene

IL2RA

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
CD_antigen: CD25
Gene namesi
Name:IL2RA
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 240ExtracellularSequence analysisAdd BLAST219
Transmembranei241 – 259HelicalSequence analysisAdd BLAST19
Topological domaini260 – 272CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001102522 – 272Interleukin-2 receptor subunit alphaAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 67PROSITE-ProRule annotation
Disulfide bondi49 ↔ 80PROSITE-ProRule annotation
Disulfide bondi51 ↔ 82PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi125 ↔ 168PROSITE-ProRule annotation
Disulfide bondi152 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000036344

Structurei

3D structure databases

ProteinModelPortaliQ5MNY4
SMRiQ5MNY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 84Sushi 1PROSITE-ProRule annotationAdd BLAST63
Domaini123 – 186Sushi 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
HOGENOMiHOG000113044
HOVERGENiHBG052109
InParanoidiQ5MNY4
KOiK05068

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5MNY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPYLLMWGL LTFITVPGCQ AELCDDDPPK ITHATFKAVA YKEGTMLNCE
60 70 80 90 100
CKRGFRRIKS GSPYMLCTGN SSHSSWDNQC QCTSSAARNT TKQVTPQPEE
110 120 130 140 150
QKERKTTEMQ SQMQLADQVS LPGHCREPPP WENEATERIY HFVVGQMVYY
160 170 180 190 200
QCVQGYRALH RGPAESICKM THGKTRWTQP QLICTGETEP SQFPGEEEPQ
210 220 230 240 250
ASPDGLPESE TSRLVTTTDF RIQTEVAATM ETFIFTTEYQ VAVAGCVFLL
260 270
ISVLLLSGLT WQRRQRKNRR TI
Length:272
Mass (Da):30,831
Last modified:February 1, 2005 - v1
Checksum:i553E9397033E61B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY693777 mRNA Translation: AAV49318.1
RefSeqiNP_001028089.1, NM_001032917.2
UniGeneiMmu.3810

Genome annotation databases

GeneIDi574300
KEGGimcc:574300

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY693777 mRNA Translation: AAV49318.1
RefSeqiNP_001028089.1, NM_001032917.2
UniGeneiMmu.3810

3D structure databases

ProteinModelPortaliQ5MNY4
SMRiQ5MNY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000036344

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574300
KEGGimcc:574300

Organism-specific databases

CTDi3559

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
HOGENOMiHOG000113044
HOVERGENiHBG052109
InParanoidiQ5MNY4
KOiK05068

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIL2RA_MACMU
AccessioniPrimary (citable) accession number: Q5MNY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 1, 2005
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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