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Entry version 94 (13 Feb 2019)
Sequence version 2 (18 May 2010)
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Protein

F-box only protein 47

Gene

FBXO47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 47
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXO471 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204952.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31969 FBXO47

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609498 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5MNV8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
494188

Open Targets

More...
OpenTargetsi
ENSG00000204952

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162388157

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FBXO47

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434512

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001199521 – 452F-box only protein 47Add BLAST452

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5MNV8

PeptideAtlas

More...
PeptideAtlasi
Q5MNV8

PRoteomics IDEntifications database

More...
PRIDEi
Q5MNV8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63588

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5MNV8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5MNV8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in kidney, liver and pancreas. Down-regulated in tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204952 Expressed in 7 organ(s), highest expression level in testis

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057438

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367319

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5MNV8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 91F-boxPROSITE-ProRule annotationAdd BLAST51

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIZ0 Eukaryota
ENOG410Z5JV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261636

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051584

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5MNV8

KEGG Orthology (KO)

More...
KOi
K10321

Identification of Orthologs from Complete Genome Data

More...
OMAi
AEVSCFK

Database of Orthologous Groups

More...
OrthoDBi
803884at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5MNV8

TreeFam database of animal gene trees

More...
TreeFami
TF343134

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR038946 FBXO47

The PANTHER Classification System

More...
PANTHERi
PTHR34098 PTHR34098, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00646 F-box, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50181 FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5MNV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRINTNFT LIPNQKLRRS NRQTSCYSKT LGSGFQPIST FGNFKALPLE
60 70 80 90 100
IFQIILKYLS VKDISMLSMV SKTVSQHIIN YISTSSGSKR LLLQDFHNLE
110 120 130 140 150
LPDRRQDSAI LEHYRSLGLL FKRCTLLLPT KERLKYIHKI LTEVSCFKFN
160 170 180 190 200
GCAAPMQCLG LTCYGMFLQT LTAGWDELEC HRVYNFLCEL TNLCRKIQMA
210 220 230 240 250
VCSKPGSAQK LELRIRLFCR NVLLDHWTHR SDSAFWLTRI LKPWPMVNQA
260 270 280 290 300
RLLYIIFGPI SPQDGQVVWQ EMIEEPTDEF SLKGLADAIK LLYDASTKEW
310 320 330 340 350
TADDVISLVD ELSVVPREWL LENNARLLML SGNNICFSFM ASKAVNGRTI
360 370 380 390 400
ELARLVVFLA LVCEKELYCM DWTVKMMQKV CKVFSTPVER KNFLQNVANA
410 420 430 440 450
FACVIMEMLQ SIMSGDRDED DRSFLNLFHL VHAQANFHKE VLYLTMNTPL

ST
Length:452
Mass (Da):51,968
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i703CBF21CAF67FB9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080770182R → G Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs759147995Ensembl.1
Natural variantiVAR_049052209Q → R2 PublicationsCorresponds to variant dbSNP:rs9906595Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY700575 mRNA Translation: AAV91324.1
AC006441 Genomic DNA No translation available.
BC140879 mRNA Translation: AAI40880.1
BC140880 mRNA Translation: AAI40881.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32639.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008777.2, NM_001008777.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.549536

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378079; ENSP00000367319; ENSG00000204952

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
494188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:494188

UCSC genome browser

More...
UCSCi
uc002hrc.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY700575 mRNA Translation: AAV91324.1
AC006441 Genomic DNA No translation available.
BC140879 mRNA Translation: AAI40880.1
BC140880 mRNA Translation: AAI40881.1
CCDSiCCDS32639.1
RefSeqiNP_001008777.2, NM_001008777.2
UniGeneiHs.549536

3D structure databases

ProteinModelPortaliQ5MNV8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367319

PTM databases

iPTMnetiQ5MNV8
PhosphoSitePlusiQ5MNV8

Polymorphism and mutation databases

BioMutaiFBXO47
DMDMi296434512

Proteomic databases

PaxDbiQ5MNV8
PeptideAtlasiQ5MNV8
PRIDEiQ5MNV8
ProteomicsDBi63588

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378079; ENSP00000367319; ENSG00000204952
GeneIDi494188
KEGGihsa:494188
UCSCiuc002hrc.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
494188
DisGeNETi494188
EuPathDBiHostDB:ENSG00000204952.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FBXO47

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0039142
HGNCiHGNC:31969 FBXO47
HPAiHPA057438
MIMi609498 gene
neXtProtiNX_Q5MNV8
OpenTargetsiENSG00000204952
PharmGKBiPA162388157

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIZ0 Eukaryota
ENOG410Z5JV LUCA
GeneTreeiENSGT00390000014175
HOGENOMiHOG000261636
HOVERGENiHBG051584
InParanoidiQ5MNV8
KOiK10321
OMAiAEVSCFK
OrthoDBi803884at2759
PhylomeDBiQ5MNV8
TreeFamiTF343134

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
494188

Protein Ontology

More...
PROi
PR:Q5MNV8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204952 Expressed in 7 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR038946 FBXO47
PANTHERiPTHR34098 PTHR34098, 1 hit
PfamiView protein in Pfam
PF00646 F-box, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX47_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5MNV8
Secondary accession number(s): B2RTZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 94 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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