UniProtKB - Q5MJP3 (SCX3_ANUPH)
Protein
Phaiodotoxin-3
Gene
phtx3
Organism
Anuroctonus phaiodactylus (Mafia scorpion)
Status
Functioni
Sodium channel (Nav) specific neurotoxin.By similarity
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Phaiodotoxin-3 |
Gene namesi | Name:phtx3Imported |
Organismi | Anuroctonus phaiodactylus (Mafia scorpion) |
Taxonomic identifieri | 246982 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Chactoidea › Chactidae › Uroctoninae › Anuroctonus |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066726 | ‹1 – 72 | Phaiodotoxin-3Add BLAST | ›72 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 13 ↔ 38 | PROSITE-ProRule annotation | ||
Disulfide bondi | 23 ↔ 50 | PROSITE-ProRule annotation | ||
Disulfide bondi | 27 ↔ 52 | PROSITE-ProRule annotation | ||
Disulfide bondi | 63 ↔ 71 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Structurei
3D structure databases
ProteinModelPortali | Q5MJP3 |
SMRi | Q5MJP3 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | ‹1 – 72 | LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | ›72 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q5MJP3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KFIRHKDESF YECGQSIGYQ QYCVDACQAH GSKEKGYCKA MAPFGLPGGC
60 70
YCPKLPSNRV KMCFGALESK CA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY781124 mRNA Translation: AAW29439.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY781124 mRNA Translation: AAW29439.1 |
3D structure databases
ProteinModelPortali | Q5MJP3 |
SMRi | Q5MJP3 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | SCX3_ANUPH | |
Accessioni | Q5MJP3Primary (citable) accession number: Q5MJP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | February 1, 2005 | |
Last modified: | July 18, 2018 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |