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Entry version 109 (07 Apr 2021)
Sequence version 1 (01 Feb 2005)
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Protein

Sperm protein associated with the nucleus on the X chromosome N2

Gene

SPANXN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5MJ10

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome N2
Alternative name(s):
Nuclear-associated protein SPAN-Xn2
Short name:
SPANX-N2
SPANX family member N2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPANXN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33175, SPANXN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300665, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5MJ10

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000268988.1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000268988

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162404384

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5MJ10, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPANXN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74743052

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002855391 – 180Sperm protein associated with the nucleus on the X chromosome N2Add BLAST180

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5MJ10

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5MJ10

PeptideAtlas

More...
PeptideAtlasi
Q5MJ10

PRoteomics IDEntifications database

More...
PRIDEi
Q5MJ10

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63582

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5MJ10

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5MJ10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000268988, Expressed in testis and 6 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000268988, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q5MJ10
With#Exp.IntAct
ANKRD1 [Q15327]3EBI-12023934,EBI-5653378
ANKRD11 [X5D778]3EBI-12023934,EBI-17183751
BANP - isoform 2 [Q8N9N5-2]3EBI-12023934,EBI-11524452
BEND7 - isoform 2 [Q8N7W2-2]3EBI-12023934,EBI-10181188
BHLHB9 [Q6PI77]3EBI-12023934,EBI-11519926
BIVM [Q86UB2]5EBI-12023934,EBI-12191873
CAVIN1 [Q6NZI2]3EBI-12023934,EBI-2559016
CDC14B [O60729]3EBI-12023934,EBI-970231
CDCA8 [Q53HL2]3EBI-12023934,EBI-979174
CDYL2 [Q8N8U2]3EBI-12023934,EBI-8467076
COIL [P38432]3EBI-12023934,EBI-945751
DPPA4 [Q7L190]3EBI-12023934,EBI-710457
EPB41L3 - isoform 2 [Q9Y2J2-2]3EBI-12023934,EBI-11100740
FAM193B [Q96PV7]3EBI-12023934,EBI-741770
FAM204A [Q9H8W3]3EBI-12023934,EBI-8465160
H2BC15 [U3KQK0]3EBI-12023934,EBI-12142839
KHDC4 - isoform 4 [Q7Z7F0-4]3EBI-12023934,EBI-9089060
KRCC1 [Q9NPI7]3EBI-12023934,EBI-2805442
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-12023934,EBI-11985629
MEOX2 [Q6FHY5]3EBI-12023934,EBI-16439278
MTIF3 [Q9H2K0]3EBI-12023934,EBI-3923617
NOL12 [Q9UGY1]3EBI-12023934,EBI-716098
PBX4 [Q9BYU1]3EBI-12023934,EBI-10302990
PICK1 [Q9NRD5]3EBI-12023934,EBI-79165
RRP1 [P56182]3EBI-12023934,EBI-2880285
SFMBT1 [Q9UHJ3]3EBI-12023934,EBI-747398
SMN2 [Q16637]3EBI-12023934,EBI-395421
SNIP1 [Q8TAD8]3EBI-12023934,EBI-749336
SNRPD2 [P62316]3EBI-12023934,EBI-297993
SP3 [Q02447]3EBI-12023934,EBI-348158
SP4 [Q02446]3EBI-12023934,EBI-10198587
SRP14 [P37108]3EBI-12023934,EBI-353399
STAC3 [Q96MF2]3EBI-12023934,EBI-745680
SYTL4 [Q96C24]3EBI-12023934,EBI-747142
THAP1 [Q9NVV9]3EBI-12023934,EBI-741515
TNNI1 [P19237]3EBI-12023934,EBI-746692
VAX1 - isoform 2 [Q5SQQ9-2]3EBI-12023934,EBI-12227803
YAF2 - isoform 2 [Q8IY57-5]3EBI-12023934,EBI-12111538
ZBTB48 [P10074]3EBI-12023934,EBI-744864
ZNF19 [P17023]3EBI-12023934,EBI-12884200
ZNF2 [Q9BSG1]3EBI-12023934,EBI-8489229
ZNF438 [Q7Z4V0]3EBI-12023934,EBI-11962468
ZNF526 [Q8TF50]3EBI-12023934,EBI-11035148
ZNF655 [Q8N720]3EBI-12023934,EBI-625509
ZNF75A [Q96N20]3EBI-12023934,EBI-21734356
ZNF84 [P51523]3EBI-12023934,EBI-2849074

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
138938, 51 interactors

Protein interaction database and analysis system

More...
IntActi
Q5MJ10, 46 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000470584

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5MJ10, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RXMW, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163956

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_140435_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5MJ10

Identification of Orthologs from Complete Genome Data

More...
OMAi
RKHTKIN

Database of Orthologous Groups

More...
OrthoDBi
1536698at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5MJ10

TreeFam database of animal gene trees

More...
TreeFami
TF341404

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010007, SPAN-X_fam

The PANTHER Classification System

More...
PANTHERi
PTHR23425, PTHR23425, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07458, SPAN-X, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5MJ10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQPTSSTNG EKRKSPCESN NKKNDEMQEA PNRVLAPKQS LQKTKTIEYL
60 70 80 90 100
TIIVYYYRKH TKINSNQLEK DQSRENSINP VQEEEDEGLD SAEGSSQEDE
110 120 130 140 150
DLDSSEGSSQ EDEDLDSSEG SSQEDEDLDS SEGSSQEDED LDSSEGSSQE
160 170 180
DEDLDPPEGS SQEDEDLDSS EGSSQEGGED
Length:180
Mass (Da):19,917
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07F91E79E1C4242F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0320258T → I1 PublicationCorresponds to variant dbSNP:rs79543398Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY825030 Genomic DNA Translation: AAV97586.1
DQ336111 mRNA Translation: ABC61862.1
DQ336112 mRNA Translation: ABC61863.1
DQ336113 mRNA Translation: ABC61864.1
DQ336114 mRNA Translation: ABC61865.1
DQ336115 mRNA Translation: ABC61866.1
AL080239 Genomic DNA Translation: CAI41652.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35419.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009615.1, NM_001009615.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000598475; ENSP00000470584; ENSG00000268988

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
494119

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:494119

UCSC genome browser

More...
UCSCi
uc033exw.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825030 Genomic DNA Translation: AAV97586.1
DQ336111 mRNA Translation: ABC61862.1
DQ336112 mRNA Translation: ABC61863.1
DQ336113 mRNA Translation: ABC61864.1
DQ336114 mRNA Translation: ABC61865.1
DQ336115 mRNA Translation: ABC61866.1
AL080239 Genomic DNA Translation: CAI41652.1
CCDSiCCDS35419.1
RefSeqiNP_001009615.1, NM_001009615.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi138938, 51 interactors
IntActiQ5MJ10, 46 interactors
STRINGi9606.ENSP00000470584

PTM databases

iPTMnetiQ5MJ10
PhosphoSitePlusiQ5MJ10

Genetic variation databases

BioMutaiSPANXN2
DMDMi74743052

Proteomic databases

MassIVEiQ5MJ10
PaxDbiQ5MJ10
PeptideAtlasiQ5MJ10
PRIDEiQ5MJ10
ProteomicsDBi63582

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
74059, 7 antibodies

The DNASU plasmid repository

More...
DNASUi
494119

Genome annotation databases

EnsembliENST00000598475; ENSP00000470584; ENSG00000268988
GeneIDi494119
KEGGihsa:494119
UCSCiuc033exw.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
494119

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPANXN2
HGNCiHGNC:33175, SPANXN2
HPAiENSG00000268988, Tissue enriched (testis)
MIMi300665, gene
neXtProtiNX_Q5MJ10
OpenTargetsiENSG00000268988
PharmGKBiPA162404384
VEuPathDBiHostDB:ENSG00000268988.1

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RXMW, Eukaryota
GeneTreeiENSGT00940000163956
HOGENOMiCLU_140435_0_0_1
InParanoidiQ5MJ10
OMAiRKHTKIN
OrthoDBi1536698at2759
PhylomeDBiQ5MJ10
TreeFamiTF341404

Enzyme and pathway databases

PathwayCommonsiQ5MJ10

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
494119, 21 hits in 532 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
494119
PharosiQ5MJ10, Tdark

Protein Ontology

More...
PROi
PR:Q5MJ10
RNActiQ5MJ10, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000268988, Expressed in testis and 6 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR010007, SPAN-X_fam
PANTHERiPTHR23425, PTHR23425, 2 hits
PfamiView protein in Pfam
PF07458, SPAN-X, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPXN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5MJ10
Secondary accession number(s): Q0ZNM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 1, 2005
Last modified: April 7, 2021
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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