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UniProtKB - Q5MCW4 (ZN569_HUMAN)

Entry version 142 (10 Feb 2021)
Sequence version 1 (01 Feb 2005)
Previous versions | rss
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Protein

Zinc finger protein 569

Gene

ZNF569

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5MCW4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 569
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF569
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24737, ZNF569

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613904, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5MCW4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196437.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		148266

Open Targets

More...OpenTargetsi		ENSG00000196437

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134899564

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5MCW4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF569

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762209

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476591 – 686Zinc finger protein 569Add BLAST686

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5MCW4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5MCW4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5MCW4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5MCW4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5MCW4

PeptideAtlas

More...PeptideAtlasi		Q5MCW4

PRoteomics IDEntifications database

More...PRIDEi		Q5MCW4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61164
63573 [Q5MCW4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5MCW4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5MCW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196437, Expressed in testis and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5MCW4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5MCW4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196437, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127137, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q5MCW4, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000325018

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5MCW4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5MCW4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154650

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_17_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5MCW4

Identification of Orthologs from Complete Genome Data

More...OMAi		QSYECNE

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5MCW4

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 18 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 11 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5MCW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTESQGTVTF KDVAIDFTQE EWKRLDPAQR KLYRNVMLEN YNNLITVGYP 
        60         70         80         90        100
FTKPDVIFKL EQEEEPWVME EEVLRRHWQG EIWGVDEHQK NQDRLLRQVE 
       110        120        130        140        150
VKFQKTLTEE KGNECQKKFA NVFPLNSDFF PSRHNLYEYD LFGKCLEHNF 
       160        170        180        190        200
DCHNNVKCLM RKEHCEYNEP VKSYGNSSSH FVITPFKCNH CGKGFNQTLD 
       210        220        230        240        250
LIRHLRIHTG EKPYECSNCR KAFSHKEKLI KHYKIHSREQ SYKCNECGKA 
       260        270        280        290        300
FIKMSNLIRH QRIHTGEKPY ACKECEKSFS QKSNLIDHEK IHTGEKPYEC 
       310        320        330        340        350
NECGKAFSQK QSLIAHQKVH TGEKPYACNE CGKAFPRIAS LALHMRSHTG 
       360        370        380        390        400
EKPYKCDKCG KAFSQFSMLI IHVRIHTGEK PYECNECGKA FSQSSALTVH 
       410        420        430        440        450
MRSHTGEKPY ECKECRKAFS HKKNFITHQK IHTREKPYEC NECGKAFIQM 
       460        470        480        490        500
SNLVRHQRIH TGEKPYICKE CGKAFSQKSN LIAHEKIHSG EKPYECNECG 
       510        520        530        540        550
KAFSQKQNFI THQKVHTGEK PYDCNECGKA FSQIASLTLH LRSHTGEKPY 
       560        570        580        590        600
ECDKCGKAFS QCSLLNLHMR SHTGEKPYVC NECGKAFSQR TSLIVHMRGH 
       610        620        630        640        650
TGEKPYECNK CGKAFSQSSS LTIHIRGHTG EKPFDCSKCG KAFSQISSLT 
       660        670        680 
LHMRKHTGEK PYHCIECGKA FSQKSHLVRH QRIHTH
Length:686
Mass (Da):79,583
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB95FC95665EA561B
GO
Isoform 2 (identifier: Q5MCW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Show »
Length:527
Mass (Da):60,421
Checksum:i3EBC08050A067AA0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELU1K7ELU1_HUMAN
Zinc finger protein 569
ZNF569 hCG_42406
710Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ12K7EJ12_HUMAN
Zinc finger protein 569
ZNF569
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENQ2K7ENQ2_HUMAN
Zinc finger protein 569
ZNF569
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKE0K7EKE0_HUMAN
Zinc finger protein 569
ZNF569
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK056615 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti598R → G in AK056615 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03558929Q → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_03559087E → G in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1349967796Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559661 – 159Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY835704 mRNA Translation: AAV97944.1
AK056615 mRNA No translation available.
AK289987 mRNA Translation: BAF82676.1
AC008806 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56728.1
BC117219 mRNA Translation: AAI17220.1
M88363 Genomic DNA Translation: AAA61321.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12503.1 [Q5MCW4-1]
CCDS82341.1 [Q5MCW4-2]

Protein sequence database of the Protein Information Resource

More...PIRi		G43284

NCBI Reference Sequences

More...RefSeqi		NP_001317411.1, NM_001330482.1 [Q5MCW4-2]
NP_689697.2, NM_152484.2 [Q5MCW4-1]
XP_011524841.1, XM_011526539.2 [Q5MCW4-1]
XP_016881865.1, XM_017026376.1 [Q5MCW4-1]
XP_016881866.1, XM_017026377.1 [Q5MCW4-1]
XP_016881868.1, XM_017026379.1 [Q5MCW4-2]
XP_016881869.1, XM_017026380.1 [Q5MCW4-2]
XP_016881871.1, XM_017026382.1 [Q5MCW4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316950; ENSP00000325018; ENSG00000196437 [Q5MCW4-1]
ENST00000392149; ENSP00000375992; ENSG00000196437 [Q5MCW4-1]
ENST00000392150; ENSP00000375993; ENSG00000196437 [Q5MCW4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		148266

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:148266

UCSC genome browser

More...UCSCi		uc002ogh.4, human [Q5MCW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY835704 mRNA Translation: AAV97944.1
AK056615 mRNA No translation available.
AK289987 mRNA Translation: BAF82676.1
AC008806 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56728.1
BC117219 mRNA Translation: AAI17220.1
M88363 Genomic DNA Translation: AAA61321.1
CCDSiCCDS12503.1 [Q5MCW4-1]
CCDS82341.1 [Q5MCW4-2]
PIRiG43284
RefSeqiNP_001317411.1, NM_001330482.1 [Q5MCW4-2]
NP_689697.2, NM_152484.2 [Q5MCW4-1]
XP_011524841.1, XM_011526539.2 [Q5MCW4-1]
XP_016881865.1, XM_017026376.1 [Q5MCW4-1]
XP_016881866.1, XM_017026377.1 [Q5MCW4-1]
XP_016881868.1, XM_017026379.1 [Q5MCW4-2]
XP_016881869.1, XM_017026380.1 [Q5MCW4-2]
XP_016881871.1, XM_017026382.1 [Q5MCW4-2]

3D structure databases

SMRiQ5MCW4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127137, 6 interactors
IntActiQ5MCW4, 6 interactors
STRINGi9606.ENSP00000325018

PTM databases

iPTMnetiQ5MCW4
PhosphoSitePlusiQ5MCW4

Genetic variation databases

BioMutaiZNF569
DMDMi74762209

Proteomic databases

EPDiQ5MCW4
jPOSTiQ5MCW4
MassIVEiQ5MCW4
MaxQBiQ5MCW4
PaxDbiQ5MCW4
PeptideAtlasiQ5MCW4
PRIDEiQ5MCW4
ProteomicsDBi61164
63573 [Q5MCW4-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		44797, 94 antibodies

Genome annotation databases

EnsembliENST00000316950; ENSP00000325018; ENSG00000196437 [Q5MCW4-1]
ENST00000392149; ENSP00000375992; ENSG00000196437 [Q5MCW4-1]
ENST00000392150; ENSP00000375993; ENSG00000196437 [Q5MCW4-2]
GeneIDi148266
KEGGihsa:148266
UCSCiuc002ogh.4, human [Q5MCW4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		148266
DisGeNETi148266

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF569
HGNCiHGNC:24737, ZNF569
HPAiENSG00000196437, Low tissue specificity
MIMi613904, gene
neXtProtiNX_Q5MCW4
OpenTargetsiENSG00000196437
PharmGKBiPA134899564
VEuPathDBiHostDB:ENSG00000196437.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000154650
HOGENOMiCLU_002678_17_1_1
InParanoidiQ5MCW4
OMAiQSYECNE
OrthoDBi1318335at2759
PhylomeDBiQ5MCW4

Enzyme and pathway databases

PathwayCommonsiQ5MCW4
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		148266, 10 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF569, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		148266
PharosiQ5MCW4, Tbio

Protein Ontology

More...PROi		PR:Q5MCW4
RNActiQ5MCW4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196437, Expressed in testis and 188 other tissues
ExpressionAtlasiQ5MCW4, baseline and differential
GenevisibleiQ5MCW4, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 18 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN569_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5MCW4
Secondary accession number(s): A8K1S2
, Q15925, Q17RR6, Q96MQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: February 1, 2005
Last modified: February 10, 2021
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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