Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 105 (16 Oct 2019)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

NKAP-like protein

Gene

NKAPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NKAP-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NKAPL
Synonyms:C6orf194
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21584 NKAPL

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5M9Q1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
222698

Open Targets

More...
OpenTargetsi
ENSG00000189134

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162397607

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5M9Q1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NKAPL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104209

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002600781 – 402NKAP-like proteinAdd BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5M9Q1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5M9Q1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5M9Q1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5M9Q1

PeptideAtlas

More...
PeptideAtlasi
Q5M9Q1

PRoteomics IDEntifications database

More...
PRIDEi
Q5M9Q1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63571

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5M9Q1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5M9Q1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189134 Expressed in 148 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5M9Q1 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RBPJ, CIR1 and HDAC3.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128814, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q5M9Q1, 9 interactors

Molecular INTeraction database

More...
MINTi
Q5M9Q1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345716

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5M9Q1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi177 – 246Lys-richAdd BLAST70

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NKAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2812 Eukaryota
ENOG4111FVK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163102

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049099

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5M9Q1

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDTWMEQ

Database of Orthologous Groups

More...
OrthoDBi
1561377at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5M9Q1

TreeFam database of animal gene trees

More...
TreeFami
TF315333

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040466 NKAP
IPR009269 NKAP_C

The PANTHER Classification System

More...
PANTHERi
PTHR13087 PTHR13087, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06047 Nkap_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5M9Q1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPVSRSSYS EDIVGSRRRR RSSSGSPPSP QSRCSSWDGC SRSHSRGREG
60 70 80 90 100
LRPPWSELDV GALYPFSRSG SRGRLPRFRN YAFASSWSTS YSGYRYHRHC
110 120 130 140 150
YAEERQSAED YEKEESHRQR RLKERERIGE LGAPEVWGPS PKFPQLDSDE
160 170 180 190 200
HTPVEDEEEV THQKSSSSDS NSEEHRKKKT SRSRNKKKRK NKSSKRKHRK
210 220 230 240 250
YSDSDSNSES DTNSDSDDDK KRVKAKKKKK KKKHKTKKKK NKKTKKESSD
260 270 280 290 300
SSCKDSEEDL SEATWMEQPN VADTMDLIGP EAPIIHTSQD EKPLKYGHAL
310 320 330 340 350
LPGEGAAMAE YVKAGKRIPR RGEIGLTSEE IGSFECSGYV MSGSRHRRME
360 370 380 390 400
AVRLRKENQI YSADEKRALA SFNQEERRKR ESKILASFRE MVHKKTKEKD

DK
Length:402
Mass (Da):46,312
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i071997D7635E219B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02899996Y → C1 PublicationCorresponds to variant dbSNP:rs12000Ensembl.1
Natural variantiVAR_029000152T → N. Corresponds to variant dbSNP:rs1635Ensembl.1
Natural variantiVAR_029001162H → Y. Corresponds to variant dbSNP:rs9461446Ensembl.1
Natural variantiVAR_029002398E → G1 PublicationCorresponds to variant dbSNP:rs1679709Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL390721 Genomic DNA No translation available.
BC038240 mRNA Translation: AAH38240.1
BC101681 mRNA Translation: AAI01682.1
BC101685 mRNA Translation: AAI01686.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34353.1

NCBI Reference Sequences

More...
RefSeqi
NP_001007532.1, NM_001007531.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343684; ENSP00000345716; ENSG00000189134

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
222698

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:222698

UCSC genome browser

More...
UCSCi
uc003nkt.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL390721 Genomic DNA No translation available.
BC038240 mRNA Translation: AAH38240.1
BC101681 mRNA Translation: AAI01682.1
BC101685 mRNA Translation: AAI01686.1
CCDSiCCDS34353.1
RefSeqiNP_001007532.1, NM_001007531.2

3D structure databases

SMRiQ5M9Q1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128814, 4 interactors
IntActiQ5M9Q1, 9 interactors
MINTiQ5M9Q1
STRINGi9606.ENSP00000345716

PTM databases

iPTMnetiQ5M9Q1
PhosphoSitePlusiQ5M9Q1

Polymorphism and mutation databases

BioMutaiNKAPL
DMDMi313104209

Proteomic databases

jPOSTiQ5M9Q1
MassIVEiQ5M9Q1
MaxQBiQ5M9Q1
PaxDbiQ5M9Q1
PeptideAtlasiQ5M9Q1
PRIDEiQ5M9Q1
ProteomicsDBi63571

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
222698

Genome annotation databases

EnsembliENST00000343684; ENSP00000345716; ENSG00000189134
GeneIDi222698
KEGGihsa:222698
UCSCiuc003nkt.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
222698
DisGeNETi222698

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NKAPL
HGNCiHGNC:21584 NKAPL
neXtProtiNX_Q5M9Q1
OpenTargetsiENSG00000189134
PharmGKBiPA162397607

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2812 Eukaryota
ENOG4111FVK LUCA
GeneTreeiENSGT00940000163102
HOGENOMiHOG000049099
InParanoidiQ5M9Q1
OMAiEDTWMEQ
OrthoDBi1561377at2759
PhylomeDBiQ5M9Q1
TreeFamiTF315333

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
222698
PharosiQ5M9Q1

Protein Ontology

More...
PROi
PR:Q5M9Q1

Gene expression databases

BgeeiENSG00000189134 Expressed in 148 organ(s), highest expression level in testis
GenevisibleiQ5M9Q1 HS

Family and domain databases

InterProiView protein in InterPro
IPR040466 NKAP
IPR009269 NKAP_C
PANTHERiPTHR13087 PTHR13087, 1 hit
PfamiView protein in Pfam
PF06047 Nkap_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNKAPL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5M9Q1
Secondary accession number(s): Q3MIV1, Q9H4Q7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 30, 2010
Last modified: October 16, 2019
This is version 105 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again