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Protein

Solute carrier family 35 member D3

Gene

SLC35D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.By similarity

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Protein family/group databases

TCDBi2.A.7.15.5 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member D3
Alternative name(s):
Fringe connection-like protein 1
Gene namesi
Name:SLC35D3
Synonyms:FRCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000182747.4
HGNCiHGNC:15621 SLC35D3
MIMi612519 gene
neXtProtiNX_Q5M8T2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi340146
OpenTargetsiENSG00000182747
PharmGKBiPA134876893

Polymorphism and mutation databases

BioMutaiSLC35D3
DMDMi74736118

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077271 – 416Solute carrier family 35 member D3Add BLAST416

Proteomic databases

PaxDbiQ5M8T2
PeptideAtlasiQ5M8T2
PRIDEiQ5M8T2
ProteomicsDBi63567

PTM databases

iPTMnetiQ5M8T2
PhosphoSitePlusiQ5M8T2

Expressioni

Gene expression databases

BgeeiENSG00000182747 Expressed in 48 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC35D3
GenevisibleiQ5M8T2 HS

Organism-specific databases

HPAiHPA030431
HPA067497

Interactioni

Protein-protein interaction databases

BioGridi131002, 3 interactors
STRINGi9606.ENSP00000333591

Structurei

3D structure databases

ProteinModelPortaliQ5M8T2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1444 Eukaryota
COG5070 LUCA
GeneTreeiENSGT00390000014204
HOGENOMiHOG000090215
HOVERGENiHBG106477
InParanoidiQ5M8T2
KOiK15281
OMAiIIHASYL
OrthoDBiEOG091G0AQT
PhylomeDBiQ5M8T2
TreeFamiTF313307

Family and domain databases

InterProiView protein in InterPro
IPR038802 Slc35d3
PANTHERiPTHR44735 PTHR44735, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M8T2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS
60 70 80 90 100
TAALSLELLR RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS
110 120 130 140 150
LPMYVVFKRC LPLVTMLIGV LVLKNGAPSP GVLAAVLITT CGAALAGAGD
160 170 180 190 200
LTGDPIGYVT GVLAVLVHAA YLVLIQKASA DTEHGPLTAQ YVIAVSATPL
210 220 230 240 250
LVICSFASTD SIHAWTFPGW KDPAMVCIFV ACILIGCAMN FTTLHCTYIN
260 270 280 290 300
SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA
310 320 330 340 350
KFMETRKQSN YEDLEAQPRG EEAQLSGDQL PFVMEELPGE GGNGRSEGGE
360 370 380 390 400
AAGGPAQESR QEVRGSPRGV PLVAGSSEEG SRRSLKDAYL EVWRLVRGTR
410
YMKKDYLIEN EELPSP
Length:416
Mass (Da):44,183
Last modified:February 1, 2005 - v1
Checksum:i7995E3B253757C79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295424 mRNA Translation: BAG58370.1
AL365223 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47939.1
BC067217 mRNA Translation: AAH67217.1
BC087842 mRNA Translation: AAH87842.1
CCDSiCCDS34544.1
RefSeqiNP_001008783.1, NM_001008783.2
UniGeneiHs.369703

Genome annotation databases

EnsembliENST00000331858; ENSP00000333591; ENSG00000182747
GeneIDi340146
KEGGihsa:340146
UCSCiuc003qhe.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295424 mRNA Translation: BAG58370.1
AL365223 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47939.1
BC067217 mRNA Translation: AAH67217.1
BC087842 mRNA Translation: AAH87842.1
CCDSiCCDS34544.1
RefSeqiNP_001008783.1, NM_001008783.2
UniGeneiHs.369703

3D structure databases

ProteinModelPortaliQ5M8T2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131002, 3 interactors
STRINGi9606.ENSP00000333591

Protein family/group databases

TCDBi2.A.7.15.5 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ5M8T2
PhosphoSitePlusiQ5M8T2

Polymorphism and mutation databases

BioMutaiSLC35D3
DMDMi74736118

Proteomic databases

PaxDbiQ5M8T2
PeptideAtlasiQ5M8T2
PRIDEiQ5M8T2
ProteomicsDBi63567

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331858; ENSP00000333591; ENSG00000182747
GeneIDi340146
KEGGihsa:340146
UCSCiuc003qhe.4 human

Organism-specific databases

CTDi340146
DisGeNETi340146
EuPathDBiHostDB:ENSG00000182747.4
GeneCardsiSLC35D3
HGNCiHGNC:15621 SLC35D3
HPAiHPA030431
HPA067497
MIMi612519 gene
neXtProtiNX_Q5M8T2
OpenTargetsiENSG00000182747
PharmGKBiPA134876893
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1444 Eukaryota
COG5070 LUCA
GeneTreeiENSGT00390000014204
HOGENOMiHOG000090215
HOVERGENiHBG106477
InParanoidiQ5M8T2
KOiK15281
OMAiIIHASYL
OrthoDBiEOG091G0AQT
PhylomeDBiQ5M8T2
TreeFamiTF313307

Miscellaneous databases

GenomeRNAii340146
PROiPR:Q5M8T2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182747 Expressed in 48 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC35D3
GenevisibleiQ5M8T2 HS

Family and domain databases

InterProiView protein in InterPro
IPR038802 Slc35d3
PANTHERiPTHR44735 PTHR44735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS35D3_HUMAN
AccessioniPrimary (citable) accession number: Q5M8T2
Secondary accession number(s): B4DI58, Q5QNZ6, Q6NX71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 1, 2005
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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