SLC35D3

Functionⁱ

May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.By similarity

GO - Biological processⁱ

carbohydrate transport Source: UniProtKB-KW
energy homeostasis Source: Ensembl
positive regulation of protein exit from endoplasmic reticulum Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Sugar transport, Transport

Biological process

Sugar transport, Transport

Protein family/group databases

TCDBⁱ	2.A.7.15.5 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.15.5 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 35 member D3 Alternative name(s): Fringe connection-like protein 1
Gene namesⁱ	Name:SLC35D3 Synonyms:FRCL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182747.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15621 SLC35D3
MIMⁱ	612519 gene
neXtProtⁱ	NX_Q5M8T2

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	9 – 29	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	38 – 58	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	64 – 84	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	103 – 123	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	131 – 151	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	155 – 175	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	187 – 207	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	224 – 244	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	257 – 277	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	280 – 300	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	340146
Open Targets More...OpenTargetsⁱ	ENSG00000182747
PharmGKBⁱ	PA134876893

Polymorphism and mutation databases

BioMutaⁱ	SLC35D3
DMDMⁱ	74736118

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000307727	1 – 416	Solute carrier family 35 member D3Add BLAST		416

Proteomic databases

PaxDbⁱ	Q5M8T2
PeptideAtlas More...PeptideAtlasⁱ	Q5M8T2
PRIDEⁱ	Q5M8T2
ProteomicsDBⁱ	63567

PTM databases

iPTMnetⁱ	Q5M8T2
PhosphoSitePlusⁱ	Q5M8T2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000182747 Expressed in 48 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_SLC35D3
Genevisibleⁱ	Q5M8T2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030431 HPA067497

HPAⁱ

HPA030431
HPA067497

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	131002, 3 interactors
STRINGⁱ	9606.ENSP00000333591

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5M8T2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TPT transporter family. SLC35D subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1444 Eukaryota COG5070 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014204
HOGENOMⁱ	HOG000090215
HOVERGENⁱ	HBG106477
InParanoidⁱ	Q5M8T2
KEGG Orthology (KO) More...KOⁱ	K15281
OMAⁱ	IIHASYL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AQT
PhylomeDBⁱ	Q5M8T2
TreeFamⁱ	TF313307

Family and domain databases

InterProⁱ	View protein in InterPro IPR038802 Slc35d3
PANTHERⁱ	PTHR44735 PTHR44735, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5M8T2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS 
        60         70         80         90        100
TAALSLELLR RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS 
       110        120        130        140        150
LPMYVVFKRC LPLVTMLIGV LVLKNGAPSP GVLAAVLITT CGAALAGAGD 
       160        170        180        190        200
LTGDPIGYVT GVLAVLVHAA YLVLIQKASA DTEHGPLTAQ YVIAVSATPL 
       210        220        230        240        250
LVICSFASTD SIHAWTFPGW KDPAMVCIFV ACILIGCAMN FTTLHCTYIN 
       260        270        280        290        300
SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA 
       310        320        330        340        350
KFMETRKQSN YEDLEAQPRG EEAQLSGDQL PFVMEELPGE GGNGRSEGGE 
       360        370        380        390        400
AAGGPAQESR QEVRGSPRGV PLVAGSSEEG SRRSLKDAYL EVWRLVRGTR 
       410 
YMKKDYLIEN EELPSP

Length:416

Mass (Da):44,183

Last modified:February 1, 2005 - v1

Checksum:ⁱ7995E3B253757C79

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK295424 mRNA Translation: BAG58370.1 AL365223 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47939.1 BC067217 mRNA Translation: AAH67217.1 BC087842 mRNA Translation: AAH87842.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34544.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001008783.1, NM_001008783.2
UniGeneⁱ	Hs.369703

Genome annotation databases

Ensemblⁱ	ENST00000331858; ENSP00000333591; ENSG00000182747
GeneIDⁱ	340146
KEGGⁱ	hsa:340146
UCSC genome browser More...UCSCⁱ	uc003qhe.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5M8T2	Uncharacterized protein		CEREH		423	UniRef90_Q5M8T2
Uncharacterized protein		MUSPF		423
Solute carrier family 35 member D3		BOVIN		423
solute carrier family 35 member D3		Enhydra lutris kenyoni		423
solute carrier family 35 member D3		PHYCD		423
+84

Protein	Similar proteins		Species	Score	Length	Source
Q5M8T2	Solute carrier family 35 member D3		MOUSE		422	UniRef50_Q8BGF8
Solute carrier family 35 member D3 (Fragment)		OPHHA		389
Solute carrier family 35 member D3		SARHA		419
Uncharacterized protein		MONDO		418
Solute carrier family 35 member D3		ORYLA		419
+235

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK295424 mRNA Translation: BAG58370.1 AL365223 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47939.1 BC067217 mRNA Translation: AAH67217.1 BC087842 mRNA Translation: AAH87842.1
CCDSⁱ	CCDS34544.1
RefSeqⁱ	NP_001008783.1, NM_001008783.2
UniGeneⁱ	Hs.369703

3D structure databases

ProteinModelPortalⁱ	Q5M8T2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131002, 3 interactors
STRINGⁱ	9606.ENSP00000333591

Protein family/group databases

TCDBⁱ	2.A.7.15.5 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.15.5 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetⁱ	Q5M8T2
PhosphoSitePlusⁱ	Q5M8T2

Polymorphism and mutation databases

BioMutaⁱ	SLC35D3
DMDMⁱ	74736118

Proteomic databases

PaxDbⁱ	Q5M8T2
PeptideAtlasⁱ	Q5M8T2
PRIDEⁱ	Q5M8T2
ProteomicsDBⁱ	63567

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000331858; ENSP00000333591; ENSG00000182747
GeneIDⁱ	340146
KEGGⁱ	hsa:340146
UCSCⁱ	uc003qhe.4 human

Organism-specific databases

CTDⁱ	340146
DisGeNETⁱ	340146
EuPathDBⁱ	HostDB:ENSG00000182747.4
GeneCardsⁱ	SLC35D3
HGNCⁱ	HGNC:15621 SLC35D3
HPAⁱ	HPA030431 HPA067497
MIMⁱ	612519 gene
neXtProtⁱ	NX_Q5M8T2
OpenTargetsⁱ	ENSG00000182747
PharmGKBⁱ	PA134876893
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1444 Eukaryota COG5070 LUCA
GeneTreeⁱ	ENSGT00390000014204
HOGENOMⁱ	HOG000090215
HOVERGENⁱ	HBG106477
InParanoidⁱ	Q5M8T2
KOⁱ	K15281
OMAⁱ	IIHASYL
OrthoDBⁱ	EOG091G0AQT
PhylomeDBⁱ	Q5M8T2
TreeFamⁱ	TF313307

Miscellaneous databases

GenomeRNAiⁱ	340146
Protein Ontology More...PROⁱ	PR:Q5M8T2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182747 Expressed in 48 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_SLC35D3
Genevisibleⁱ	Q5M8T2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR038802 Slc35d3
PANTHERⁱ	PTHR44735 PTHR44735, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S35D3_HUMAN
Accessionⁱ	Q5M8T2Primary (citable) accession number: Q5M8T2 Secondary accession number(s): B4DI58, Q5QNZ6, Q6NX71
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
	Last sequence update:	February 1, 2005
	Last modified:	November 7, 2018
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5M8T2 (S35D3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Solute carrier family 35 member D3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endoplasmic reticulum

Endosome

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ