UniProtKB - Q5M8T2 (S35D3_HUMAN)
Protein
Solute carrier family 35 member D3
Gene
SLC35D3
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.By similarity
GO - Molecular functioni
- antiporter activity Source: GO_Central
- pyrimidine nucleotide-sugar transmembrane transporter activity Source: GO_Central
- transmembrane transporter activity Source: GO_Central
- UDP-glucuronic acid transmembrane transporter activity Source: GO_Central
- UDP-N-acetylgalactosamine transmembrane transporter activity Source: GO_Central
- UDP-N-acetylglucosamine transmembrane transporter activity Source: GO_Central
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
- energy homeostasis Source: Ensembl
- positive regulation of protein exit from endoplasmic reticulum Source: Ensembl
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q5M8T2 |
Protein family/group databases
TCDBi | 2.A.7.15.5, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 35 member D3Alternative name(s): Fringe connection-like protein 1 |
Gene namesi | Name:SLC35D3 Synonyms:FRCL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15621, SLC35D3 |
MIMi | 612519, gene |
neXtProti | NX_Q5M8T2 |
VEuPathDBi | HostDB:ENSG00000182747.4 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Endosome
- early endosome Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 38 – 58 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 257 – 277 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 280 – 300 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 340146 |
OpenTargetsi | ENSG00000182747 |
PharmGKBi | PA134876893 |
Miscellaneous databases
Pharosi | Q5M8T2, Tdark |
Genetic variation databases
BioMutai | SLC35D3 |
DMDMi | 74736118 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307727 | 1 – 416 | Solute carrier family 35 member D3Add BLAST | 416 |
Proteomic databases
jPOSTi | Q5M8T2 |
MassIVEi | Q5M8T2 |
PaxDbi | Q5M8T2 |
PeptideAtlasi | Q5M8T2 |
PRIDEi | Q5M8T2 |
ProteomicsDBi | 63567 |
PTM databases
iPTMneti | Q5M8T2 |
PhosphoSitePlusi | Q5M8T2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182747, Expressed in pigmented layer of retina and 59 other tissues |
Genevisiblei | Q5M8T2, HS |
Organism-specific databases
HPAi | ENSG00000182747, Tissue enhanced (brain, retina) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131002, 3 interactors |
IntActi | Q5M8T2, 2 interactors |
STRINGi | 9606.ENSP00000333591 |
Miscellaneous databases
RNActi | Q5M8T2, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1444, Eukaryota |
GeneTreei | ENSGT00940000160083 |
HOGENOMi | CLU_040726_3_0_1 |
InParanoidi | Q5M8T2 |
OMAi | GWKDPTM |
OrthoDBi | 972218at2759 |
PhylomeDBi | Q5M8T2 |
TreeFami | TF313307 |
i Sequence
Sequence statusi: Complete.
Q5M8T2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS
60 70 80 90 100
TAALSLELLR RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS
110 120 130 140 150
LPMYVVFKRC LPLVTMLIGV LVLKNGAPSP GVLAAVLITT CGAALAGAGD
160 170 180 190 200
LTGDPIGYVT GVLAVLVHAA YLVLIQKASA DTEHGPLTAQ YVIAVSATPL
210 220 230 240 250
LVICSFASTD SIHAWTFPGW KDPAMVCIFV ACILIGCAMN FTTLHCTYIN
260 270 280 290 300
SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA
310 320 330 340 350
KFMETRKQSN YEDLEAQPRG EEAQLSGDQL PFVMEELPGE GGNGRSEGGE
360 370 380 390 400
AAGGPAQESR QEVRGSPRGV PLVAGSSEEG SRRSLKDAYL EVWRLVRGTR
410
YMKKDYLIEN EELPSP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295424 mRNA Translation: BAG58370.1 AL365223 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47939.1 BC067217 mRNA Translation: AAH67217.1 BC087842 mRNA Translation: AAH87842.1 |
CCDSi | CCDS34544.1 |
RefSeqi | NP_001008783.1, NM_001008783.2 |
Genome annotation databases
Ensembli | ENST00000331858; ENSP00000333591; ENSG00000182747 |
GeneIDi | 340146 |
KEGGi | hsa:340146 |
UCSCi | uc003qhe.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295424 mRNA Translation: BAG58370.1 AL365223 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47939.1 BC067217 mRNA Translation: AAH67217.1 BC087842 mRNA Translation: AAH87842.1 |
CCDSi | CCDS34544.1 |
RefSeqi | NP_001008783.1, NM_001008783.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 131002, 3 interactors |
IntActi | Q5M8T2, 2 interactors |
STRINGi | 9606.ENSP00000333591 |
Protein family/group databases
TCDBi | 2.A.7.15.5, the drug/metabolite transporter (dmt) superfamily |
PTM databases
iPTMneti | Q5M8T2 |
PhosphoSitePlusi | Q5M8T2 |
Genetic variation databases
BioMutai | SLC35D3 |
DMDMi | 74736118 |
Proteomic databases
jPOSTi | Q5M8T2 |
MassIVEi | Q5M8T2 |
PaxDbi | Q5M8T2 |
PeptideAtlasi | Q5M8T2 |
PRIDEi | Q5M8T2 |
ProteomicsDBi | 63567 |
Protocols and materials databases
Antibodypediai | 33021, 64 antibodies |
Genome annotation databases
Ensembli | ENST00000331858; ENSP00000333591; ENSG00000182747 |
GeneIDi | 340146 |
KEGGi | hsa:340146 |
UCSCi | uc003qhe.4, human |
Organism-specific databases
CTDi | 340146 |
DisGeNETi | 340146 |
GeneCardsi | SLC35D3 |
HGNCi | HGNC:15621, SLC35D3 |
HPAi | ENSG00000182747, Tissue enhanced (brain, retina) |
MIMi | 612519, gene |
neXtProti | NX_Q5M8T2 |
OpenTargetsi | ENSG00000182747 |
PharmGKBi | PA134876893 |
VEuPathDBi | HostDB:ENSG00000182747.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1444, Eukaryota |
GeneTreei | ENSGT00940000160083 |
HOGENOMi | CLU_040726_3_0_1 |
InParanoidi | Q5M8T2 |
OMAi | GWKDPTM |
OrthoDBi | 972218at2759 |
PhylomeDBi | Q5M8T2 |
TreeFami | TF313307 |
Enzyme and pathway databases
PathwayCommonsi | Q5M8T2 |
Miscellaneous databases
BioGRID-ORCSi | 340146, 4 hits in 875 CRISPR screens |
GenomeRNAii | 340146 |
Pharosi | Q5M8T2, Tdark |
PROi | PR:Q5M8T2 |
RNActi | Q5M8T2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182747, Expressed in pigmented layer of retina and 59 other tissues |
Genevisiblei | Q5M8T2, HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S35D3_HUMAN | |
Accessioni | Q5M8T2Primary (citable) accession number: Q5M8T2 Secondary accession number(s): B4DI58, Q5QNZ6, Q6NX71 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | February 1, 2005 | |
Last modified: | February 10, 2021 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families