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Protein
Submitted name:

Serine (Or cysteine) proteinase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 4

Gene

Serpina4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Serine (Or cysteine) proteinase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 4Imported
Submitted name:
Serine (Or cysteine) proteinase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 4, isoform CRA_aImported
Submitted name:
Serpin family A member 4Imported
Gene namesi
Name:Serpina4Imported
ORF Names:rCG_20663Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi708581 Serpina4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501430986221 – 423Sequence analysisAdd BLAST403

Expressioni

Gene expression databases

BgeeiENSRNOG00000009788 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013045

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 421SERPINInterPro annotationAdd BLAST365

Sequence similaritiesi

Belongs to the serpin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOVERGENiHBG005957
KOiK04525
OMAiQVPMMLQ
OrthoDBiEOG091G0ION
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M8C3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHYTRCLLLL LAGLLELSHS QPDQEEPDNT TNQTYRQFSQ QNISSYQIAS
60 70 80 90 100
GNANFAFRLY HLIASQNSEK NIFFSPLSIS VSLAILSTGA GGDTQAQILE
110 120 130 140 150
GLGFNLTKLS LPEIHEGFRS LQHTIARPFT EPQISVGSAL ILSQNLQILS
160 170 180 190 200
EFVSAIETSY NSKVLHANFR DKEAAVQLIN NYVKQNTQGK IKNLVSDLSP
210 220 230 240 250
DVKMVLVNYI FFQGLWKKPF PSSRVSTSDF YVDENTVVKI PMMLQDKEDH
260 270 280 290 300
WYLEDRRVPC TVLRMDYRGD AVAFFILPDQ GKMNEVEQVL SPGMLLRWKR
310 320 330 340 350
LLQNRFFYRK LILQLPKFSI SNSYELDEIL PDLGFQDLFT PNANFSNISK
360 370 380 390 400
KEKLYLSKVF HKTVLDVNEV GTKAAAATGS FATFFSAQPK KRYLIFNRPF
410 420
LVILYSTSSQ DILFMGKVVN PTA
Length:423
Mass (Da):48,047
Last modified:February 1, 2005 - v1
Checksum:i7859FD14DEC6848D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119346 Genomic DNA No translation available.
BC088111 mRNA Translation: AAH88111.1
CH473982 Genomic DNA Translation: EDL81795.1
RefSeqiNP_659565.2, NM_145097.2
XP_008762963.1, XM_008764741.1
UniGeneiRn.11152

Genome annotation databases

EnsembliENSRNOT00000013045; ENSRNOP00000013045; ENSRNOG00000009788
GeneIDi246328
KEGGirno:246328
UCSCiRGD:708581 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119346 Genomic DNA No translation available.
BC088111 mRNA Translation: AAH88111.1
CH473982 Genomic DNA Translation: EDL81795.1
RefSeqiNP_659565.2, NM_145097.2
XP_008762963.1, XM_008764741.1
UniGeneiRn.11152

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013045

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013045; ENSRNOP00000013045; ENSRNOG00000009788
GeneIDi246328
KEGGirno:246328
UCSCiRGD:708581 rat

Organism-specific databases

CTDi5267
RGDi708581 Serpina4

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOVERGENiHBG005957
KOiK04525
OMAiQVPMMLQ
OrthoDBiEOG091G0ION
TreeFamiTF343201

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation

Gene expression databases

BgeeiENSRNOG00000009788 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5M8C3_RAT
AccessioniPrimary (citable) accession number: Q5M8C3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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