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Protein

Apolipoprotein F

Gene

Apof

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.By similarity

GO - Biological processi

Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein F
Short name:
Apo-F
Alternative name(s):
Liver regeneration-related protein LRRG151
Gene namesi
Name:Apof
ORF Names:Ba1-666
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1560713 Apof

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, LDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000002055? – 154Sequence analysis
Signal peptidei1 – ?Sequence analysis
ChainiPRO_0000002056155 – 308Apolipoprotein FAdd BLAST154

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ5M889
PRIDEiQ5M889

Expressioni

Gene expression databases

BgeeiENSRNOG00000033619

Structurei

3D structure databases

SMRiQ5M889
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein F family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2UW Eukaryota
ENOG4112458 LUCA
GeneTreeiENSGT00500000045104
HOGENOMiHOG000034007
HOVERGENiHBG050551
InParanoidiQ5M889
OMAiVWALQLQ
OrthoDBiEOG091G0O2P
PhylomeDBiQ5M889
TreeFamiTF338778

Family and domain databases

InterProiView protein in InterPro
IPR026114 APOF
PANTHERiPTHR15011 PTHR15011, 1 hit
PfamiView protein in Pfam
PF15148 Apolipo_F, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5M889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQLLTCTV SDSIRHQFSC FATSCCVLWV PKGVSTMLPP SQLGSQPPTS
60 70 80 90 100
DPLSCQALLP RSLPGFTHMP PLSKFLVGLA LRNALEEAGC WADVWALQLQ
110 120 130 140 150
LYRFGGVEAT QALIRHLQEL QKGGRADWKV SVNALSSALQ LLAWEQAGPK
160 170 180 190 200
RVKRSLSNMG CENEQEQRVH NVVELLPAVG TYYNLGTALY YAIKNCTDKA
210 220 230 240 250
KERGRDGAID LGYDLLMTMV GMSGGPTGAV ITAALKPALK AGVQRLIRYY
260 270 280 290 300
HDEEGVTTSQ PETRKDAPTY RDDVEETTMS NLVSEVESTT SNWGRPLLKN

YVFLAYKR
Length:308
Mass (Da):33,842
Last modified:February 1, 2005 - v1
Checksum:i490B55D6A3692F46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088170 mRNA Translation: AAH88170.1
AY325229 mRNA Translation: AAP92630.1
RefSeqiNP_001019522.1, NM_001024351.1
UniGeneiRn.101696

Genome annotation databases

EnsembliENSRNOT00000041341; ENSRNOP00000049259; ENSRNOG00000033619
GeneIDi500761
KEGGirno:500761
UCSCiRGD:1560713 rat

Similar proteinsi

Entry informationi

Entry nameiAPOF_RAT
AccessioniPrimary (citable) accession number: Q5M889
Secondary accession number(s): Q7TP25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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