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Protein

Chloride intracellular channel protein 2

Gene

Clic2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-RNO-2672351 Stimuli-sensing channels
R-RNO-5578775 Ion homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 2
Gene namesi
Name:Clic2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1306580 Clic2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52Helical; Note=After insertion into the membraneSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442061 – 245Chloride intracellular channel protein 2Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 33In soluble formBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5M883
PRIDEiQ5M883

PTM databases

iPTMnetiQ5M883
PhosphoSitePlusiQ5M883

Expressioni

Gene expression databases

BgeeiENSRNOG00000000728 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiQ5M883 RN

Interactioni

Subunit structurei

Monomer. Interacts with TRAPPC2 and RYR2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000955

Structurei

3D structure databases

ProteinModelPortaliQ5M883
SMRiQ5M883
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 239GST C-terminalAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96Required for insertion into the membraneBy similarityAdd BLAST96

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1422 Eukaryota
ENOG410ZRK6 LUCA
GeneTreeiENSGT00550000074477
HOGENOMiHOG000231548
HOVERGENiHBG050994
InParanoidiQ5M883
KOiK05022
OMAiSHTCPAD
OrthoDBiEOG091G0IHT
PhylomeDBiQ5M883
TreeFamiTF315438

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030253 CLIC-2
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF4 PTHR43920:SF4, 1 hit
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M883-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLALNTQA DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT
60 70 80 90 100
TIDTARKPEE LKDLAPGTNP PFLIYNKELK TDFIKIEEFL EKTLAPPRYP
110 120 130 140 150
HLSPKYKESF DVGCNLFAKF SAYIKNTQKE ANKNFEKSLL REFKRLDDYL
160 170 180 190 200
NTPLLDEIDP DSTEERTLSR RLFLDGDQLT LADCSLLPKL NIIKVAAKKY
210 220 230 240
RDFDIPAEFS GVWRYLHNAY AREEFAHTCP EDKEIENTYA SVAKQ
Length:245
Mass (Da):28,161
Last modified:February 1, 2005 - v1
Checksum:iDE6379E6FC9C86A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088182 mRNA Translation: AAH88182.1
RefSeqiNP_001009651.1, NM_001009651.1
UniGeneiRn.103254

Genome annotation databases

EnsembliENSRNOT00000000955; ENSRNOP00000000955; ENSRNOG00000000728
GeneIDi294141
KEGGirno:294141
UCSCiRGD:1306580 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088182 mRNA Translation: AAH88182.1
RefSeqiNP_001009651.1, NM_001009651.1
UniGeneiRn.103254

3D structure databases

ProteinModelPortaliQ5M883
SMRiQ5M883
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000955

PTM databases

iPTMnetiQ5M883
PhosphoSitePlusiQ5M883

Proteomic databases

PaxDbiQ5M883
PRIDEiQ5M883

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000955; ENSRNOP00000000955; ENSRNOG00000000728
GeneIDi294141
KEGGirno:294141
UCSCiRGD:1306580 rat

Organism-specific databases

CTDi1193
RGDi1306580 Clic2

Phylogenomic databases

eggNOGiKOG1422 Eukaryota
ENOG410ZRK6 LUCA
GeneTreeiENSGT00550000074477
HOGENOMiHOG000231548
HOVERGENiHBG050994
InParanoidiQ5M883
KOiK05022
OMAiSHTCPAD
OrthoDBiEOG091G0IHT
PhylomeDBiQ5M883
TreeFamiTF315438

Enzyme and pathway databases

ReactomeiR-RNO-2672351 Stimuli-sensing channels
R-RNO-5578775 Ion homeostasis

Miscellaneous databases

PROiPR:Q5M883

Gene expression databases

BgeeiENSRNOG00000000728 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiQ5M883 RN

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030253 CLIC-2
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF4 PTHR43920:SF4, 1 hit
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLIC2_RAT
AccessioniPrimary (citable) accession number: Q5M883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: February 1, 2005
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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