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Protein

SPRY domain-containing SOCS box protein 2

Gene

Spsb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-8951664 Neddylation
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing SOCS box protein 2
Short name:
SSB-2
Gene namesi
Name:Spsb2
Synonyms:Ssb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 4, Chromosome 9

Organism-specific databases

RGDi1310854 Spsb2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384761 – 264SPRY domain-containing SOCS box protein 2Add BLAST264

Proteomic databases

PaxDbiQ5M877

Expressioni

Gene expression databases

BgeeiENSRNOG00000015125 Expressed in 9 organ(s), highest expression level in spleen
GenevisibleiQ5M877 RN

Interactioni

Subunit structurei

Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB2. Interacts with CUL5, RNF7, ELOB and ELOC. Interacts with MET. Interacts (via B30.2/SPRY domain) with PAWR; this interaction occurs in association with the Elongin BC complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064453

Structurei

3D structure databases

ProteinModelPortaliQ5M877
SMRiQ5M877
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 221B30.2/SPRYPROSITE-ProRule annotationAdd BLAST196
Domaini222 – 264SOCS boxPROSITE-ProRule annotationAdd BLAST43

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the SPSB family.Curated

Phylogenomic databases

eggNOGiKOG3953 Eukaryota
ENOG410XQC1 LUCA
GeneTreeiENSGT00390000009402
HOGENOMiHOG000230524
HOVERGENiHBG055793
InParanoidiQ5M877
KOiK10344
OMAiISWPREQ
OrthoDBiEOG091G0DF0
PhylomeDBiQ5M877
TreeFamiTF312822

Family and domain databases

CDDicd03719 SOCS_SSB2, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
IPR003877 SPRY_dom
IPR037340 SSB2_SOCS
PfamiView protein in Pfam
PF07525 SOCS_box, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q5M877-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQTALARGS SSTPSSHALY SDLSPPEGLE ELLSAPPPDL GAQRHHGWNP
60 70 80 90 100
KDCSENIDVK EGGLCFERRP VAQSTDGVRG KRGYSRGLHA WEISWPLEQR
110 120 130 140 150
GTHAVVGVAT ALAPLQADHY AALLGSNSES WGWDIGRGKL YHQSKGLEAP
160 170 180 190 200
QYPAGPQGEQ LVVPERLLVV LDMEEGTLGY SIGGTYLGPA FRGLKGRTLY
210 220 230 240 250
PSVSAVWGQC QVRIRYLGER RAEEPQSLLH LSRLCVRHAL GDTRLGQISS
260
LPLPPAMKRY LLYK
Length:264
Mass (Da):28,797
Last modified:February 1, 2005 - v1
Checksum:i2C3578010FE81C02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088189 mRNA Translation: AAH88189.1
RefSeqiNP_001009660.1, NM_001009660.1
XP_003750703.1, XM_003750655.4
UniGeneiRn.162769

Genome annotation databases

EnsembliENSRNOT00000020493; ENSRNOP00000020493; ENSRNOG00000015125
ENSRNOT00000072086; ENSRNOP00000064453; ENSRNOG00000047113
GeneIDi100911548
297592
KEGGirno:100911548
rno:297592
UCSCiRGD:1310854 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088189 mRNA Translation: AAH88189.1
RefSeqiNP_001009660.1, NM_001009660.1
XP_003750703.1, XM_003750655.4
UniGeneiRn.162769

3D structure databases

ProteinModelPortaliQ5M877
SMRiQ5M877
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064453

Proteomic databases

PaxDbiQ5M877

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020493; ENSRNOP00000020493; ENSRNOG00000015125
ENSRNOT00000072086; ENSRNOP00000064453; ENSRNOG00000047113
GeneIDi100911548
297592
KEGGirno:100911548
rno:297592
UCSCiRGD:1310854 rat

Organism-specific databases

CTDi84727
RGDi1310854 Spsb2

Phylogenomic databases

eggNOGiKOG3953 Eukaryota
ENOG410XQC1 LUCA
GeneTreeiENSGT00390000009402
HOGENOMiHOG000230524
HOVERGENiHBG055793
InParanoidiQ5M877
KOiK10344
OMAiISWPREQ
OrthoDBiEOG091G0DF0
PhylomeDBiQ5M877
TreeFamiTF312822

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-RNO-8951664 Neddylation
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q5M877

Gene expression databases

BgeeiENSRNOG00000015125 Expressed in 9 organ(s), highest expression level in spleen
GenevisibleiQ5M877 RN

Family and domain databases

CDDicd03719 SOCS_SSB2, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
IPR003877 SPRY_dom
IPR037340 SSB2_SOCS
PfamiView protein in Pfam
PF07525 SOCS_box, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPSB2_RAT
AccessioniPrimary (citable) accession number: Q5M877
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 1, 2005
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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