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Protein

E3 ubiquitin-protein ligase RNFT1

Gene

RNFT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri375 – 413RING-typePROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNFT1Curated (EC:2.3.2.271 Publication)
Alternative name(s):
Protein PTD016
RING finger and transmembrane domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNFT1
ORF Names:PTD016
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000189050.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30206 RNFT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615172 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5M7Z0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi375C → S: Decreased ubiquitin ligase activity; when associated with S-378. 1 Publication1
Mutagenesisi378C → S: Decreased ubiquitin ligase activity; when associated with S-375. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000189050

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162401921

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNFT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121947809

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206351 – 435E3 ubiquitin-protein ligase RNFT1Add BLAST435

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5M7Z0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5M7Z0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5M7Z0

PeptideAtlas

More...
PeptideAtlasi
Q5M7Z0

PRoteomics IDEntifications database

More...
PRIDEi
Q5M7Z0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63564
63565 [Q5M7Z0-2]
63566 [Q5M7Z0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5M7Z0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5M7Z0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in testis, lower levels in heart, liver, lung, and kidney (PubMed:17074343). Not detected in brain, ovary, and uterus (PubMed:17074343). Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS) (PubMed:17074343). Ubiquitously expressed with high expression in testis (PubMed:27485036).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by endoplasmic reticulum (ER) stress triggered by thapsigargin or tunicamycin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189050 Expressed in 191 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_RNFT1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5M7Z0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5M7Z0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013739

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119323, 6 interactors

Protein interaction database and analysis system

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IntActi
Q5M7Z0, 3 interactors

Molecular INTeraction database

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MINTi
Q5M7Z0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304670

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5M7Z0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni368 – 419Required for ubiquitin ligase activity and for protection against ER stress-induced cell death1 PublicationAdd BLAST52

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri375 – 413RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0802 Eukaryota
KOG4638 Eukaryota
ENOG410XTGA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156740

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000237544

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG056546

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5M7Z0

KEGG Orthology (KO)

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KOi
K22379

Identification of Orthologs from Complete Genome Data

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OMAi
PVLLICQ

Database of Orthologous Groups

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OrthoDBi
EOG091G0FD6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5M7Z0

TreeFam database of animal gene trees

More...
TreeFami
TF331930

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184 RING, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5M7Z0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLFLLSLPT PPSASGHERR QRPEAKTSGS EKKYLRAMQA NRSQLHSPPG
60 70 80 90 100
TGSSEDASTP QCVHTRLTGE GSCPHSGDVH IQINSIPKEC AENASSRNIR
110 120 130 140 150
SGVHSCAHGC VHSRLRGHSH SEARLTDDTA AESGDHGSSS FSEFRYLFKW
160 170 180 190 200
LQKSLPYILI LSVKLVMQHI TGISLGIGLL TTFMYANKSI VNQVFLRERS
210 220 230 240 250
SKIQCAWLLV FLAGSSVLLY YTFHSQSLYY SLIFLNPTLD HLSFWEVFWI
260 270 280 290 300
VGITDFILKF FFMGLKCLIL LVPSFIMPFK SKGYWYMLLE ELCQYYRTFV
310 320 330 340 350
PIPVWFRYLI SYGEFGNVTR WSLGILLALL YLILKLLEFF GHLRTFRQVL
360 370 380 390 400
RIFFTQPSYG VAASKRQCSD VDDICSICQA EFQKPILLIC QHIFCEECMT
410 420 430
LWFNREKTCP LCRTVISDHI NKWKDGATSS HLQIY
Length:435
Mass (Da):49,710
Last modified:September 19, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60773323485B08A8
GO
Isoform 2 (identifier: Q5M7Z0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-203: ERSSKI → VSITSN
     204-435: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:203
Mass (Da):22,149
Checksum:i3F8B8C99D6424341
GO
Isoform 3 (identifier: Q5M7Z0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-245: ERSSKIQCAW...NPTLDHLSFW → LNFFKSYFGP...FIGAFFHHAF
     246-435: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:245
Mass (Da):27,302
Checksum:i4F77053348078907
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEZ8H0YEZ8_HUMAN
E3 ubiquitin-protein ligase RNFT1
RNFT1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI44E9PI44_HUMAN
E3 ubiquitin-protein ligase RNFT1
RNFT1
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ18K7EJ18_HUMAN
E3 ubiquitin-protein ligase RNFT1
RNFT1
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD43009 differs from that shown. Reason: Frameshift at positions 150 and 167.Curated
Isoform 2 : The sequence AAD43009 differs from that shown. Reason: Frameshift at position 199.Curated
The sequence BAC05364 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q5M7Z0-2)
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti199S → K in AAD43009 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031700198 – 245ERSSK…HLSFW → LNFFKSYFGPFELLGSILDC WNYRLHSEILFHGLKMPYFI GAFFHHAF in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_031698198 – 203ERSSKI → VSITSN in isoform 2. 1 Publication6
Alternative sequenceiVSP_031699204 – 435Missing in isoform 2. 1 PublicationAdd BLAST232
Alternative sequenceiVSP_031701246 – 435Missing in isoform 3. 1 PublicationAdd BLAST190

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF100745 mRNA Translation: AAD43009.1 Frameshift.
AC004686 mRNA No translation available.
AC005702 mRNA No translation available.
CH471109 Genomic DNA Translation: EAW94381.1
BC006971 mRNA No translation available.
BC088365 mRNA Translation: AAH88365.2
AK098649 mRNA Translation: BAC05364.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11622.2 [Q5M7Z0-1]

NCBI Reference Sequences

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RefSeqi
NP_057209.3, NM_016125.3 [Q5M7Z0-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.531701

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305783; ENSP00000304670; ENSG00000189050 [Q5M7Z0-1]
ENST00000482446; ENSP00000436144; ENSG00000189050 [Q5M7Z0-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51136

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51136

UCSC genome browser

More...
UCSCi
uc002iya.4 human [Q5M7Z0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100745 mRNA Translation: AAD43009.1 Frameshift.
AC004686 mRNA No translation available.
AC005702 mRNA No translation available.
CH471109 Genomic DNA Translation: EAW94381.1
BC006971 mRNA No translation available.
BC088365 mRNA Translation: AAH88365.2
AK098649 mRNA Translation: BAC05364.1 Different initiation.
CCDSiCCDS11622.2 [Q5M7Z0-1]
RefSeqiNP_057209.3, NM_016125.3 [Q5M7Z0-1]
UniGeneiHs.531701

3D structure databases

ProteinModelPortaliQ5M7Z0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119323, 6 interactors
IntActiQ5M7Z0, 3 interactors
MINTiQ5M7Z0
STRINGi9606.ENSP00000304670

PTM databases

iPTMnetiQ5M7Z0
PhosphoSitePlusiQ5M7Z0

Polymorphism and mutation databases

BioMutaiRNFT1
DMDMi121947809

Proteomic databases

EPDiQ5M7Z0
MaxQBiQ5M7Z0
PaxDbiQ5M7Z0
PeptideAtlasiQ5M7Z0
PRIDEiQ5M7Z0
ProteomicsDBi63564
63565 [Q5M7Z0-2]
63566 [Q5M7Z0-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51136
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305783; ENSP00000304670; ENSG00000189050 [Q5M7Z0-1]
ENST00000482446; ENSP00000436144; ENSG00000189050 [Q5M7Z0-3]
GeneIDi51136
KEGGihsa:51136
UCSCiuc002iya.4 human [Q5M7Z0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51136
EuPathDBiHostDB:ENSG00000189050.14

GeneCards: human genes, protein and diseases

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GeneCardsi
RNFT1
HGNCiHGNC:30206 RNFT1
HPAiHPA013739
MIMi615172 gene
neXtProtiNX_Q5M7Z0
OpenTargetsiENSG00000189050
PharmGKBiPA162401921

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0802 Eukaryota
KOG4638 Eukaryota
ENOG410XTGA LUCA
GeneTreeiENSGT00940000156740
HOGENOMiHOG000237544
HOVERGENiHBG056546
InParanoidiQ5M7Z0
KOiK22379
OMAiPVLLICQ
OrthoDBiEOG091G0FD6
PhylomeDBiQ5M7Z0
TreeFamiTF331930

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51136

Protein Ontology

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PROi
PR:Q5M7Z0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000189050 Expressed in 191 organ(s), highest expression level in testis
CleanExiHS_RNFT1
ExpressionAtlasiQ5M7Z0 baseline and differential
GenevisibleiQ5M7Z0 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNFT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5M7Z0
Secondary accession number(s): Q8N7D0, Q96IZ9, Q9Y686
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 19, 2006
Last modified: December 5, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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