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Protein
Submitted name:

Serine (Or cysteine) peptidase inhibitor, clade C (Antithrombin), member 1

Gene

Serpinc1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-140837 Intrinsic Pathway of Fibrin Clot Formation
R-RNO-140875 Common Pathway of Fibrin Clot Formation
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade C (Antithrombin), member 1Imported
Submitted name:
Serpin family C member 1Imported
Gene namesi
Name:Serpinc1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1307404 Serpinc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_501430989335 – 465Sequence analysisAdd BLAST431

Expressioni

Gene expression databases

BgeeiENSRNOG00000002783 Expressed in 9 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046072

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 462SERPINInterPro annotationAdd BLAST370

Sequence similaritiesi

Belongs to the serpin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000238519
HOVERGENiHBG005957
KOiK03911
OMAiSNKTEGR
OrthoDBiEOG091G0ION

Family and domain databases

CDDicd02045 antithrombin-III_like, 1 hit
InterProiView protein in InterPro
IPR033829 Antithrombin_domain
IPR015555 AT-III
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF53 PTHR11461:SF53, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5M7T5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSPGIGSAV AGERKLCLLS LLLIGALGCA VCHGNPVDDI CIAKPRDIPV
60 70 80 90 100
NPMCIYRSPA KKATEEDVLE QKVPEATNRR VWELSKANSR FATNFYQHLA
110 120 130 140 150
DSKNDNDNIF LSPLSISTAF AMTKLGACNN TLKQLMEVFK FDTISEKTSD
160 170 180 190 200
QIHFFFAKLN CRLYRKANKS SNLVSANRLF GDKSLTFNES YQDVSEIVYG
210 220 230 240 250
AKLQPLDFKE NPEQSRVTIN NWVANKTEGR IKDVIPQGAI DELTALVLVN
260 270 280 290 300
TIYFKGLWKS KFSPENTRKE PFHKVDGQSC LVPMMYQEGK FKYRRVGEGT
310 320 330 340 350
QVLEMPFKGD DITMVLILPK PEKSLAKVEQ ELTPELLQEW LDELSEVMLV
360 370 380 390 400
VHVPRFRIED SFSLKEQLQD MGLVDLFSPE KSQLPGIIAE GRDDLFVSDA
410 420 430 440 450
FHKAFLEVNE EGSEAAASTS VVITGRSLNP SRVTFKANRP FLVLIREVAL
460
NTIIFMGRVS NPCVN
Length:465
Mass (Da):52,234
Last modified:February 1, 2005 - v1
Checksum:i6D017853B7284B0C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096MIW4A0A096MIW4_RAT
Serpin family C member 1
Serpinc1
79Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113837 Genomic DNA No translation available.
BC088467 mRNA Translation: AAH88467.1
RefSeqiNP_001012027.1, NM_001012027.1
UniGeneiRn.204806

Genome annotation databases

EnsembliENSRNOT00000003748; ENSRNOP00000003748; ENSRNOG00000002783
GeneIDi304917
KEGGirno:304917

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113837 Genomic DNA No translation available.
BC088467 mRNA Translation: AAH88467.1
RefSeqiNP_001012027.1, NM_001012027.1
UniGeneiRn.204806

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046072

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003748; ENSRNOP00000003748; ENSRNOG00000002783
GeneIDi304917
KEGGirno:304917

Organism-specific databases

CTDi462
RGDi1307404 Serpinc1

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000238519
HOVERGENiHBG005957
KOiK03911
OMAiSNKTEGR
OrthoDBiEOG091G0ION

Enzyme and pathway databases

ReactomeiR-RNO-140837 Intrinsic Pathway of Fibrin Clot Formation
R-RNO-140875 Common Pathway of Fibrin Clot Formation
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Gene expression databases

BgeeiENSRNOG00000002783 Expressed in 9 organ(s), highest expression level in liver

Family and domain databases

CDDicd02045 antithrombin-III_like, 1 hit
InterProiView protein in InterPro
IPR033829 Antithrombin_domain
IPR015555 AT-III
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF53 PTHR11461:SF53, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5M7T5_RAT
AccessioniPrimary (citable) accession number: Q5M7T5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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