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Entry version 68 (08 May 2019)
Sequence version 1 (01 Feb 2005)
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Protein

Tudor domain-containing protein 7

Gene

tdrd7

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tudor domain-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tdrd7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-944683 tdrd7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004095211 – 1077Tudor domain-containing protein 7Add BLAST1077

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5M7P8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000062111

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5M7P8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 67HTH OST-type 1PROSITE-ProRule annotationAdd BLAST67
Domaini220 – 289HTH OST-type 2PROSITE-ProRule annotationAdd BLAST70
Domaini330 – 398HTH OST-type 3PROSITE-ProRule annotationAdd BLAST69
Domaini494 – 551Tudor 1PROSITE-ProRule annotationAdd BLAST58
Domaini684 – 741Tudor 2PROSITE-ProRule annotationAdd BLAST58

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TDRD7 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294063

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5M7P8

KEGG Orthology (KO)

More...
KOi
K18405

Database of Orthologous Groups

More...
OrthoDBi
1276848at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09974 LOTUS_3_TDRD7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1880, 3 hits
2.40.50.90, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041966 LOTUS-like
IPR025605 OST-HTH/LOTUS_dom
IPR035437 SNase_OB-fold_sf
IPR037978 TDRD7_LOTUS_3
IPR002999 Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12872 OST-HTH, 2 hits
PF00567 TUDOR, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333 TUDOR, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51644 HTH_OST, 3 hits
PS50304 TUDOR, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5M7P8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRAVLQANK NGVPLSKLQA EYKSFTGEPI PFKDMGFHAL DAYLKSIPSV
60 70 80 90 100
VRIEVSRVGE VICYAVVCKE TARIAALVAH QRSSKKKSGG QVNCQMRLKY
110 120 130 140 150
TAPVSHFGKP KATLRQPGFT PPQEKIIRKP VPTSAWGKGN TFGSRTFEYS
160 170 180 190 200
PPPIPQLFGI APIQMHLPNI NRPERKVTLP PRFQREVNSF LNPTPMTDSN
210 220 230 240 250
ANHTQSLKSV VPGSGQPRCD LSVIQNNLKE LLNKHSNGLW LSKLPQLYKE
260 270 280 290 300
TYKQDLGGEM LKQVPSWTHI CMVQKLVTMG HTEMVLYSTA IKQPSFTKNV
310 320 330 340 350
QNHSNNQAKP NVPVDSTPSS PPLQSSGNIP KDELKQKISK VLTKYSNGLW
360 370 380 390 400
YHALPKVFED MFKQKLPTEV LNLDSLTDIC TVDLISEEPF KAILYAKSAE
410 420 430 440 450
RANQNSNPSV NNNIPQKLQD RESPLLPEEP EMNMTPPPLV IPSEASPSVL
460 470 480 490 500
VVELSSTNDV VIRYIGRDYS AAQEHMEDEM KDFCSKSSTA KIGFLRVGQL
510 520 530 540 550
VAAKAEEDVW LRAQISAIEG KKVKVCYVDY GFSEIVDITK VCKLGKQFYT
560 570 580 590 600
LPFQATKCRL AGLEAFCDDS IIIKALELKA CGKILAVEIL EKSEKPLVVL
610 620 630 640 650
YDTSGDDDIN INAACLKELC DRSLSLQLKA NSSFSNVIVT NVCSDGTLFC
660 670 680 690 700
QLPSKGLAKL YETLQKVDSE FQSKQVTSHL YVSLPFCGKI CLYHYKGKWA
710 720 730 740 750
RVEITSVHSS RALDVQFLDS GTIASVKVSE LKEIPPPLLR DLISIPPQAL
760 770 780 790 800
RCCLADLPLR IGMWTPDAVL WLRNTVLNCL ECSIRVVKVD EATNMVHIYL
810 820 830 840 850
FTSNNFPDLE RSINRQITNE ELWKHQKDVF LNLSASTLES SRGGGAQASE
860 870 880 890 900
LSPPGLCKDH TSAVKKPDMQ QSSSVPSFNM PPPLPLPRPG EHMDVFVSVA
910 920 930 940 950
CHPGHFVCQP WQELHKLEVV MEEMLLHYST TEEKPVALEK NKLYAAKVEN
960 970 980 990 1000
KWYRVLVKGI LTNGLVSVYE LDYGRHELVS CRKVQPLIEK FMQLPFQAIT
1010 1020 1030 1040 1050
SQLAGVSCEH WSEEASIVFR NHVEKKPLVA LVQTIHESTH PWDRRAVAYI
1060 1070
VDTSLPDTDI WIHELMTEYH IQLSKPE
Length:1,077
Mass (Da):120,613
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9E1D056023AC478
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6UC31F6UC31_XENTR
Tudor domain-containing protein 7
tdrd7
1,114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7AAK0F7AAK0_XENTR
Tudor domain-containing protein 7
tdrd7
1,077Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC088519 mRNA Translation: AAH88519.1

NCBI Reference Sequences

More...
RefSeqi
NP_001011355.2, NM_001011355.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
496822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:496822

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088519 mRNA Translation: AAH88519.1
RefSeqiNP_001011355.2, NM_001011355.2

3D structure databases

SMRiQ5M7P8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000062111

Proteomic databases

PRIDEiQ5M7P8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi496822
KEGGixtr:496822

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23424
XenbaseiXB-GENE-944683 tdrd7

Phylogenomic databases

HOGENOMiHOG000294063
InParanoidiQ5M7P8
KOiK18405
OrthoDBi1276848at2759

Family and domain databases

CDDicd09974 LOTUS_3_TDRD7, 1 hit
Gene3Di1.10.10.1880, 3 hits
2.40.50.90, 3 hits
InterProiView protein in InterPro
IPR041966 LOTUS-like
IPR025605 OST-HTH/LOTUS_dom
IPR035437 SNase_OB-fold_sf
IPR037978 TDRD7_LOTUS_3
IPR002999 Tudor
PfamiView protein in Pfam
PF12872 OST-HTH, 2 hits
PF00567 TUDOR, 3 hits
SMARTiView protein in SMART
SM00333 TUDOR, 3 hits
PROSITEiView protein in PROSITE
PS51644 HTH_OST, 3 hits
PS50304 TUDOR, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDRD7_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5M7P8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: February 1, 2005
Last modified: May 8, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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