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Protein

SEC14 domain and spectrin repeat-containing protein 1

Gene

sestd1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels trpc4 and trpc5. Binds phospholipids (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14 domain and spectrin repeat-containing protein 1
Gene namesi
Name:sestd1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-977656 sestd1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094811 – 696SEC14 domain and spectrin repeat-containing protein 1Add BLAST696

Proteomic databases

PaxDbiQ5M7P4

Expressioni

Gene expression databases

BgeeiENSXETG00000015051 Expressed in 13 organ(s), highest expression level in heart
ExpressionAtlasiQ5M7P4 baseline

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032937

Structurei

3D structure databases

ProteinModelPortaliQ5M7P4
SMRiQ5M7P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 153CRAL-TRIOPROSITE-ProRule annotationAdd BLAST153
Repeati272 – 378Spectrin 1Add BLAST107
Repeati381 – 494Spectrin 2Add BLAST114
Repeati500 – 602Spectrin 3Add BLAST103

Sequence similaritiesi

Belongs to the SOLO family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPZN LUCA
GeneTreeiENSGT00730000111148
HOGENOMiHOG000072717
HOVERGENiHBG104429
InParanoidiQ5M7P4

Family and domain databases

CDDicd00170 SEC14, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
SUPFAMiSSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q5M7P4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDATVILPIL KKKLAFLSGG KDRRSGLILT IPLCSDQTSM DELSVTLDYL
60 70 80 90 100
LSIPSDKCKA RGFTVIVDGR KSQWNVVKTV VLMLQNVVPA EVSLVCVVKP
110 120 130 140 150
DEFWDKKVTH FCFWKEKDRL GFEVILVSGN KLTRYIEPNQ LTEEFGGSLT
160 170 180 190 200
YDHMDWLNKR LVFEKFTKES TSLLDELAVI NNGSDKGSQN EKERSVDFNY
210 220 230 240 250
LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE LLAQPQVMKL
260 270 280 290 300
LDSLREQYTR YQEVCRQRSK RTQLDEIQQK VMQVVNWLEG PGSEQLRTQW
310 320 330 340 350
GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV
360 370 380 390 400
ELKTLQQRLS DVCYRQASQL EFRQNLLQTA LDFHSVAQDL SQQLDGLLGM
410 420 430 440 450
LCVDVAPTDG AAIQQTLKLL EEKLKSVDTG LQGLREKGQG LLDQITNQAS
460 470 480 490 500
WAYGKDVSTE NKDNVDHIQG IMEDMQLRKQ RCEDMVDVRR LKMLQMVQLF
510 520 530 540 550
KCEEDAAQAV DWLNELLDAL LKTHIRLGDD SQETKILLEK HRKFVDVAQS
560 570 580 590 600
TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PKLNRVWKQF TITSEERVHR
610 620 630 640 650
LEMALAFHSN AEKILQECPD LGETVMDFEQ FDEVEAVGKS VLDRLTVPVI
660 670 680 690
YPDGTEQYFG TPSDMASTAE HIRERIKMVC LKKQQLLEPD ESIRES
Length:696
Mass (Da):79,421
Last modified:February 1, 2005 - v1
Checksum:iC0F8FACA605DE73A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7DGK3F7DGK3_XENTR
SEC14 domain and spectrin repeat-co...
sestd1
697Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088523 mRNA Translation: AAH88523.1
RefSeqiNP_001011359.1, NM_001011359.1
UniGeneiStr.15546

Genome annotation databases

EnsembliENSXETT00000062079; ENSXETP00000058869; ENSXETG00000015051
GeneIDi496826
KEGGixtr:496826

Similar proteinsi

Entry informationi

Entry nameiSESD1_XENTR
AccessioniPrimary (citable) accession number: Q5M7P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 1, 2005
Last modified: September 12, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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