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UniProtKB - Q5M7N9 (ESYT3_XENTR)
Protein
Extended synaptotagmin-3
Gene
esyt3
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 363 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 364 | Calcium 1By similarity | 1 | |
Metal bindingi | 364 | Calcium 2By similarity | 1 | |
Metal bindingi | 376 | Calcium 2By similarity | 1 | |
Metal bindingi | 423 | Calcium 1By similarity | 1 | |
Metal bindingi | 423 | Calcium 2By similarity | 1 | |
Metal bindingi | 424 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 425 | Calcium 1By similarity | 1 | |
Metal bindingi | 425 | Calcium 2By similarity | 1 | |
Metal bindingi | 425 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 427 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 429 | Calcium 3By similarity | 1 | |
Metal bindingi | 430 | Calcium 1By similarity | 1 |
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: GO_Central
- calcium ion binding Source: GO_Central
- phosphatidylcholine binding Source: GO_Central
- phosphatidylethanolamine binding Source: GO_Central
- phosphatidylinositol binding Source: GO_Central
GO - Biological processi
- endoplasmic reticulum-plasma membrane tethering Source: InterPro
- lipid transport Source: UniProtKB-KW
Keywordsi
Biological process | Lipid transport, Transport |
Ligand | Calcium, Lipid-binding, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Extended synaptotagmin-3Short name: E-Syt3 |
Gene namesi | Name:esyt3 Synonyms:fam62c |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-5746165, esyt3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Recruited to the cell membrane via the third C2 domain (By similarity).By similarity
Endoplasmic reticulum
- intrinsic component of endoplasmic reticulum membrane Source: GO_Central
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
Other locations
- endoplasmic reticulum-plasma membrane contact site Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 66 | CytoplasmicSequence analysisAdd BLAST | 66 | |
Transmembranei | 67 – 91 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 113 – 889 | CytoplasmicSequence analysisAdd BLAST | 777 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000314901 | 1 – 889 | Extended synaptotagmin-3Add BLAST | 889 |
Proteomic databases
PRIDEi | Q5M7N9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 155 – 333 | SMP-LTDPROSITE-ProRule annotationAdd BLAST | 179 | |
Domaini | 331 – 452 | C2 1PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 468 – 618 | C2 2PROSITE-ProRule annotationAdd BLAST | 151 | |
Domaini | 757 – 879 | C2 3PROSITE-ProRule annotationAdd BLAST | 123 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 65 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 648 – 724 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 804 – 811 | Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membraneBy similarity | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 669 – 720 | Polar residuesSequence analysisAdd BLAST | 52 |
Domaini
The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior (By similarity).By similarity
Sequence similaritiesi
Belongs to the extended synaptotagmin family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | Q5M7N9 |
OrthoDBi | 52746at2759 |
Family and domain databases
CDDi | cd08391, C2A_C2C_Synaptotagmin_like, 1 hit cd04050, C2B_Synaptotagmin-like, 1 hit cd04030, C2C_KIAA1228, 1 hit |
Gene3Di | 2.60.40.150, 3 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037752, C2C_KIAA1228 IPR037733, Ext_Synaptotagmin_C2A IPR037749, Ext_Synaptotagmin_C2B IPR031468, SMP_LBD IPR039010, Synaptotagmin_SMP |
Pfami | View protein in Pfam PF00168, C2, 3 hits PF17047, SMP_LBD, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 3 hits |
SUPFAMi | SSF49562, SSF49562, 3 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 3 hits PS51847, SMP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5M7N9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQGDPGGQT PQAPQGTDKK PDEPKATEKP QGAGPQPRDP PGGEKGLRDP
60 70 80 90 100
PGGEKGPRDP GQGGAGEALA EALYGLGRPV LRAVLYLFPV YLCGRFGLSP
110 120 130 140 150
TWLLFGLFLW MFWTRNKKFK LARIQAAWDL HENEKLGVTR GLYLQQLPAW
160 170 180 190 200
VNFPDVERVE WLNKVVGQMW PYIGMYVEKM FQDKVEPLVR SSSAHLKAFT
210 220 230 240 250
FTKVHLGEKF PRINGVKSYT KNVDKREVIL DLQLSYNGDV EINVEVKKMC
260 270 280 290 300
KAGVKGVQLH GTLRVILAPL LPDLPFVGAV TMFFIQRPHL DINWTGLTNV
310 320 330 340 350
LEIPGVSDFS DSMIVDMIAS HLVLPNRFTV PLSSQVQAAQ LRFPLPHGVL
360 370 380 390 400
RLHLIEAEDL IPKDNYLKGI IRGKSDPYAV LRIGNQNFKS RTIKENLNPK
410 420 430 440 450
WGEMYEFVVH EVPGQDLEVD LYDEDPDKDD FLGSLVIGLE GVMQDRVVDE
460 470 480 490 500
WFPLSDVPSG SVHLRLEWLS LLPKSEKLSE AKGGISTAML IVYLDSASAL
510 520 530 540 550
PRNHFEYSSS EYTTRKQRHM TYTKTDKDPN SYVLMSVGKK SVKSKTCTGS
560 570 580 590 600
TEPVWGQAFA FFIQDVHMQH LHLEVKDSER QCALGMLDLP LHRLLGNEEL
610 620 630 640 650
TADQRFPLAN SGPNSTIKMK IVLRVLHVEA PEPESIYTGI NSLKQGPVSI
660 670 680 690 700
KRAQSQQHKS HGKSHQAHHQ AHQTQQNHTV QQPKAERKES ISTTSQQANT
710 720 730 740 750
SSSNPAPNQN PNSTGAVPES HTPSLKPLER IAPSLLSLNS IGSSVFDPND
760 770 780 790 800
KRWPSEMTGE VEVSVRYASL RRCLVVLINS CRNLIQCSSN GADPYVRIYL
810 820 830 840 850
LPDRKWSGRK KTSVKRKTLN PQYNERFEFL VSQEEAKKRM LDVAVKNNRG
860 870 880
FGSHERKELG KVLVDLSCDD LVKGFTKWFE LTPTGLPTS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC088530 mRNA Translation: AAH88530.1 |
RefSeqi | NP_001011364.1, NM_001011364.1 |
Genome annotation databases
GeneIDi | 496831 |
KEGGi | xtr:496831 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC088530 mRNA Translation: AAH88530.1 |
RefSeqi | NP_001011364.1, NM_001011364.1 |
3D structure databases
SMRi | Q5M7N9 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q5M7N9 |
Genome annotation databases
GeneIDi | 496831 |
KEGGi | xtr:496831 |
Organism-specific databases
CTDi | 83850 |
Xenbasei | XB-GENE-5746165, esyt3 |
Phylogenomic databases
InParanoidi | Q5M7N9 |
OrthoDBi | 52746at2759 |
Family and domain databases
CDDi | cd08391, C2A_C2C_Synaptotagmin_like, 1 hit cd04050, C2B_Synaptotagmin-like, 1 hit cd04030, C2C_KIAA1228, 1 hit |
Gene3Di | 2.60.40.150, 3 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037752, C2C_KIAA1228 IPR037733, Ext_Synaptotagmin_C2A IPR037749, Ext_Synaptotagmin_C2B IPR031468, SMP_LBD IPR039010, Synaptotagmin_SMP |
Pfami | View protein in Pfam PF00168, C2, 3 hits PF17047, SMP_LBD, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 3 hits |
SUPFAMi | SSF49562, SSF49562, 3 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 3 hits PS51847, SMP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ESYT3_XENTR | |
Accessioni | Q5M7N9Primary (citable) accession number: Q5M7N9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | February 1, 2005 | |
Last modified: | September 29, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families