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Entry version 72 (29 Sep 2021)
Sequence version 1 (01 Feb 2005)
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Protein

Extended synaptotagmin-3

Gene

esyt3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi363Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi364Calcium 1By similarity1
Metal bindingi364Calcium 2By similarity1
Metal bindingi376Calcium 2By similarity1
Metal bindingi423Calcium 1By similarity1
Metal bindingi423Calcium 2By similarity1
Metal bindingi424Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi425Calcium 1By similarity1
Metal bindingi425Calcium 2By similarity1
Metal bindingi425Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi427Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi429Calcium 3By similarity1
Metal bindingi430Calcium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extended synaptotagmin-3
Short name:
E-Syt3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:esyt3
Synonyms:fam62c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5746165, esyt3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 66CytoplasmicSequence analysisAdd BLAST66
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei67 – 91HelicalSequence analysisAdd BLAST25
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 889CytoplasmicSequence analysisAdd BLAST777

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003149011 – 889Extended synaptotagmin-3Add BLAST889

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5M7N9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5M7N9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 333SMP-LTDPROSITE-ProRule annotationAdd BLAST179
Domaini331 – 452C2 1PROSITE-ProRule annotationAdd BLAST122
Domaini468 – 618C2 2PROSITE-ProRule annotationAdd BLAST151
Domaini757 – 879C2 3PROSITE-ProRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 65DisorderedSequence analysisAdd BLAST65
Regioni648 – 724DisorderedSequence analysisAdd BLAST77
Regioni804 – 811Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membraneBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16Polar residuesSequence analysisAdd BLAST16
Compositional biasi669 – 720Polar residuesSequence analysisAdd BLAST52

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the extended synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5M7N9

Database of Orthologous Groups

More...
OrthoDBi
52746at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08391, C2A_C2C_Synaptotagmin_like, 1 hit
cd04050, C2B_Synaptotagmin-like, 1 hit
cd04030, C2C_KIAA1228, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037752, C2C_KIAA1228
IPR037733, Ext_Synaptotagmin_C2A
IPR037749, Ext_Synaptotagmin_C2B
IPR031468, SMP_LBD
IPR039010, Synaptotagmin_SMP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 3 hits
PF17047, SMP_LBD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49562, SSF49562, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 3 hits
PS51847, SMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5M7N9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQGDPGGQT PQAPQGTDKK PDEPKATEKP QGAGPQPRDP PGGEKGLRDP
60 70 80 90 100
PGGEKGPRDP GQGGAGEALA EALYGLGRPV LRAVLYLFPV YLCGRFGLSP
110 120 130 140 150
TWLLFGLFLW MFWTRNKKFK LARIQAAWDL HENEKLGVTR GLYLQQLPAW
160 170 180 190 200
VNFPDVERVE WLNKVVGQMW PYIGMYVEKM FQDKVEPLVR SSSAHLKAFT
210 220 230 240 250
FTKVHLGEKF PRINGVKSYT KNVDKREVIL DLQLSYNGDV EINVEVKKMC
260 270 280 290 300
KAGVKGVQLH GTLRVILAPL LPDLPFVGAV TMFFIQRPHL DINWTGLTNV
310 320 330 340 350
LEIPGVSDFS DSMIVDMIAS HLVLPNRFTV PLSSQVQAAQ LRFPLPHGVL
360 370 380 390 400
RLHLIEAEDL IPKDNYLKGI IRGKSDPYAV LRIGNQNFKS RTIKENLNPK
410 420 430 440 450
WGEMYEFVVH EVPGQDLEVD LYDEDPDKDD FLGSLVIGLE GVMQDRVVDE
460 470 480 490 500
WFPLSDVPSG SVHLRLEWLS LLPKSEKLSE AKGGISTAML IVYLDSASAL
510 520 530 540 550
PRNHFEYSSS EYTTRKQRHM TYTKTDKDPN SYVLMSVGKK SVKSKTCTGS
560 570 580 590 600
TEPVWGQAFA FFIQDVHMQH LHLEVKDSER QCALGMLDLP LHRLLGNEEL
610 620 630 640 650
TADQRFPLAN SGPNSTIKMK IVLRVLHVEA PEPESIYTGI NSLKQGPVSI
660 670 680 690 700
KRAQSQQHKS HGKSHQAHHQ AHQTQQNHTV QQPKAERKES ISTTSQQANT
710 720 730 740 750
SSSNPAPNQN PNSTGAVPES HTPSLKPLER IAPSLLSLNS IGSSVFDPND
760 770 780 790 800
KRWPSEMTGE VEVSVRYASL RRCLVVLINS CRNLIQCSSN GADPYVRIYL
810 820 830 840 850
LPDRKWSGRK KTSVKRKTLN PQYNERFEFL VSQEEAKKRM LDVAVKNNRG
860 870 880
FGSHERKELG KVLVDLSCDD LVKGFTKWFE LTPTGLPTS
Length:889
Mass (Da):99,594
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7A888F1C6E1DA54
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC088530 mRNA Translation: AAH88530.1

NCBI Reference Sequences

More...
RefSeqi
NP_001011364.1, NM_001011364.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
496831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:496831

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088530 mRNA Translation: AAH88530.1
RefSeqiNP_001011364.1, NM_001011364.1

3D structure databases

SMRiQ5M7N9
ModBaseiSearch...

Proteomic databases

PRIDEiQ5M7N9

Genome annotation databases

GeneIDi496831
KEGGixtr:496831

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83850
XenbaseiXB-GENE-5746165, esyt3

Phylogenomic databases

InParanoidiQ5M7N9
OrthoDBi52746at2759

Family and domain databases

CDDicd08391, C2A_C2C_Synaptotagmin_like, 1 hit
cd04050, C2B_Synaptotagmin-like, 1 hit
cd04030, C2C_KIAA1228, 1 hit
Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037752, C2C_KIAA1228
IPR037733, Ext_Synaptotagmin_C2A
IPR037749, Ext_Synaptotagmin_C2B
IPR031468, SMP_LBD
IPR039010, Synaptotagmin_SMP
PfamiView protein in Pfam
PF00168, C2, 3 hits
PF17047, SMP_LBD, 1 hit
SMARTiView protein in SMART
SM00239, C2, 3 hits
SUPFAMiSSF49562, SSF49562, 3 hits
PROSITEiView protein in PROSITE
PS50004, C2, 3 hits
PS51847, SMP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESYT3_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5M7N9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: September 29, 2021
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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