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Entry version 125 (31 Jul 2019)
Sequence version 1 (01 Feb 2005)
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Protein

Cytospin-B

Gene

SPECC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytospin-B
Alternative name(s):
Nuclear structure protein 5
Short name:
NSP5
Sperm antigen HCMOGT-1
Sperm antigen with calponin homology and coiled-coil domains 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPECC1
Synonyms:CYTSB, NSP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30615 SPECC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608793 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5M775

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CYTSB may be a cause of juvenile myelomonocytic leukemia. Translocation t(5;17)(q33;p11.2) with PDGFRB.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
92521

Open Targets

More...
OpenTargetsi
ENSG00000128487

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164718712

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPECC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74722683

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002540331 – 1068Cytospin-BAdd BLAST1068
Isoform 3 (identifier: Q5M775-3)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
Isoform 4 (identifier: Q5M775-4)
Initiator methionineiRemoved1 Publication
Isoform 5 (identifier: Q5M775-5)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei38PhosphoserineBy similarity1
Modified residuei55PhosphoserineCombined sources1
Modified residuei78PhosphothreonineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei137PhosphoserineBy similarity1
Modified residuei138PhosphoserineCombined sources1
Modified residuei142PhosphothreonineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei361PhosphoserineBy similarity1
Modified residuei366PhosphoserineBy similarity1
Modified residuei369PhosphoserineBy similarity1
Modified residuei425PhosphoserineCombined sources1
Modified residuei847PhosphoserineCombined sources1
Modified residuei863PhosphoserineCombined sources1
Modified residuei912PhosphoserineCombined sources1
Modified residuei914PhosphoserineCombined sources1
Isoform 3 (identifier: Q5M775-3)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
Isoform 4 (identifier: Q5M775-4)
Lipidationi2N-myristoyl glycine1 Publication1
Isoform 5 (identifier: Q5M775-5)
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5M775

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5M775

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5M775

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5M775

PeptideAtlas

More...
PeptideAtlasi
Q5M775

PRoteomics IDEntifications database

More...
PRIDEi
Q5M775

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63559 [Q5M775-1]
63560 [Q5M775-2]
63561 [Q5M775-3]
63562 [Q5M775-4]
63563 [Q5M775-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5M775

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5M775

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis. Barely detectable in other tissues. Also highly expressed in some cancer cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128487 Expressed in 153 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5M775 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5M775 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021421
HPA021430

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124953, 68 interactors

Protein interaction database and analysis system

More...
IntActi
Q5M775, 50 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261503

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5M775

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini962 – 1067Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili579 – 773Sequence analysisAdd BLAST195

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi260 – 372Ser-richAdd BLAST113

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytospin-A family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4678 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153592

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5M775

KEGG Orthology (KO)

More...
KOi
K23028

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYLEHSP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5M775

TreeFam database of animal gene trees

More...
TreeFami
TF316716

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5M775-1) [UniParc]FASTAAdd to basket
Also known as: NSP5beta3beta

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSAAKPWNP AIRAGGHGPD RVRPLPAASS GMKSSKSSTS LAFESRLSRL
60 70 80 90 100
KRASSEDTLN KPGSTAASGV VRLKKTATAG AISELTESRL RSGTGAFTTT
110 120 130 140 150
KRTGIPAPRE FSVTVSRERS VPRGPSNPRK SVSSPTSSNT PTPTKHLRTP
160 170 180 190 200
STKPKQENEG GEKAALESQV RELLAEAKAK DSEINRLRSE LKKYKEKRTL
210 220 230 240 250
NAEGTDALGP NVDGTSVSPG DTEPMIRALE EKNKNFQKEL SDLEEENRVL
260 270 280 290 300
KEKLIYLEHS PNSEGAASHT GDSSCPTSIT QESSFGSPTG NQMSSDIDEY
310 320 330 340 350
KKNIHGNALR TSGSSSSDVT KASLSPDASD FEHITAETPS RPLSSTSNPF
360 370 380 390 400
KSSKCSTAGS SPNSVSELSL ASLTEKIQKM EENHHSTAEE LQATLQELSD
410 420 430 440 450
QQQMVQELTA ENEKLVDEKT ILETSFHQHR ERAEQLSQEN EKLMNLLQER
460 470 480 490 500
VKNEEPTTQE GKIIELEQKC TGILEQGRFE REKLLNIQQQ LTCSLRKVEE
510 520 530 540 550
ENQGALEMIK RLKEENEKLN EFLELERHNN NMMAKTLEEC RVTLEGLKME
560 570 580 590 600
NGSLKSHLQG EKQKATEASA VEQTAESCEV QEMLKVARAE KDLLELSCNE
610 620 630 640 650
LRQELLKANG EIKHVSSLLA KVEKDYSYLK EICDHQAEQL SRTSLKLQEK
660 670 680 690 700
ASESDAEIKD MKETIFELED QVEQHRAVKL HNNQLISELE SSVIKLEEQK
710 720 730 740 750
SDLERQLKTL TKQMKEETEE WRRFQADLQT AVVVANDIKC EAQQELRTVK
760 770 780 790 800
RKLLEEEEKN ARLQKELGDV QGHGRVVTSR AAPPPVDEEP ESSEVDAAGR
810 820 830 840 850
WPGVCVSRTS PTPPESATTV KSLIKSFDLG RPGGAGQNIS VHKTPRSPLS
860 870 880 890 900
GIPVRTAPAA AVSPMQRHST YSSVRPASRG VTQRLDLPDL PLSDILKGRT
910 920 930 940 950
ETLKPDPHLR KSPSLESLSR PPSLGFGDTR LLSASTRAWK PQSKLSVERK
960 970 980 990 1000
DPLAALAREY GGSKRNALLK WCQKKTQGYA NIDITNFSSS WSDGLAFCAL
1010 1020 1030 1040 1050
LHTYLPAHIP YQELNSQEKK RNLLLAFEAA ESVGIKPSLE LSEMLYTDRP
1060
DWQSVMQYVA QIYKYFET
Length:1,068
Mass (Da):118,585
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6FB6987C835A1CA
GO
Isoform 2 (identifier: Q5M775-2) [UniParc]FASTAAdd to basket
Also known as: NSP5beta3alpha

The sequence of this isoform differs from the canonical sequence as follows:
     785-790: PVDEEP → SLGSVS
     791-1068: Missing.

Show »
Length:790
Mass (Da):87,888
Checksum:iEBA37084509E44BF
GO
Isoform 3 (identifier: Q5M775-3) [UniParc]FASTAAdd to basket
Also known as: NSP5alpha3alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MRSAAKPWNP...LTESRLRSGT → MGNHSGRPEDPEP
     785-790: PVDEEP → SLGSVS
     791-1068: Missing.

Show »
Length:709
Mass (Da):79,546
Checksum:iB381B7FE6D6AF509
GO
Isoform 4 (identifier: Q5M775-4) [UniParc]FASTAAdd to basket
Also known as: NSP5alpha3beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MRSAAKPWNP...LTESRLRSGT → MGNHSGRPEDPEP

Show »
Length:987
Mass (Da):110,242
Checksum:iAC1AB9E2C3C29B8B
GO
Isoform 5 (identifier: Q5M775-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MRSAAKPWNP...LTESRLRSGT → MGNHSGRPEDPEP
     785-1068: Missing.

Show »
Length:703
Mass (Da):79,015
Checksum:i150996E18DC39F99
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KSG2J3KSG2_HUMAN
Cytospin-B
SPECC1
534Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTI9J3KTI9_HUMAN
Cytospin-B
SPECC1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRB9J3KRB9_HUMAN
Cytospin-B
SPECC1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRD8J3KRD8_HUMAN
Cytospin-B
SPECC1
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS22J3QS22_HUMAN
Cytospin-B
SPECC1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRQ9J3QRQ9_HUMAN
Cytospin-B
SPECC1
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQM0J3QQM0_HUMAN
Cytospin-B
SPECC1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRN9J3KRN9_HUMAN
Cytospin-B
SPECC1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSD6J3QSD6_HUMAN
Cytospin-B
SPECC1
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKL1J3QKL1_HUMAN
Cytospin-B
SPECC1
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH33618 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB16440 differs from that shown. Reason: Frameshift at position 8.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164 – 170AALESQV → VRLSPKF in BAB16440 (Ref. 1) Curated7
Sequence conflicti179A → S in BAB16440 (Ref. 1) Curated1
Sequence conflicti179A → S in AAW30001 (PubMed:15602574).Curated1
Sequence conflicti330D → N in AAH50058 (PubMed:15489334).Curated1
Sequence conflicti359G → R in AAH50058 (PubMed:15489334).Curated1
Sequence conflicti364S → I in AAH33618 (PubMed:15489334).Curated1
Sequence conflicti382E → G in AAW29999 (PubMed:15602574).Curated1
Sequence conflicti382E → G in AAW30000 (PubMed:15602574).Curated1
Sequence conflicti382E → G in AAW30002 (PubMed:15602574).Curated1
Sequence conflicti434 – 435EQ → DE in AAH50058 (PubMed:15489334).Curated2
Sequence conflicti831R → G in AAW30000 (PubMed:15602574).Curated1
Sequence conflicti831R → G in AAW30002 (PubMed:15602574).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053055274S → R1 PublicationCorresponds to variant dbSNP:rs9908032Ensembl.1
Natural variantiVAR_028800293M → L4 PublicationsCorresponds to variant dbSNP:rs2703806Ensembl.1
Natural variantiVAR_053056769D → N. Corresponds to variant dbSNP:rs35835131Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0211621 – 94MRSAA…LRSGT → MGNHSGRPEDPEP in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST94
Alternative sequenceiVSP_021163785 – 1068Missing in isoform 5. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_021164785 – 790PVDEEP → SLGSVS in isoform 2 and isoform 3. 2 Publications6
Alternative sequenceiVSP_021165791 – 1068Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST278

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB041533 mRNA Translation: BAB16440.1 Frameshift.
AY816326 mRNA Translation: AAW29999.1
AY816327 mRNA Translation: AAW30000.1
AY816328 mRNA Translation: AAW30001.1
AY816329 mRNA Translation: AAW30002.1
BK005598 Genomic DNA Translation: DAA05629.1
BK005598 Genomic DNA Translation: DAA05630.1
BK005598 Genomic DNA Translation: DAA05631.1
BK005598 Genomic DNA Translation: DAA05632.1
AK295093 mRNA Translation: BAG58132.1
AC005730 Genomic DNA No translation available.
BC021123 mRNA Translation: AAH21123.2
BC033618 mRNA Translation: AAH33618.1 Different initiation.
BC050058 mRNA Translation: AAH50058.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32590.1 [Q5M775-1]
CCDS42280.1 [Q5M775-2]
CCDS42281.1 [Q5M775-4]
CCDS45628.1 [Q5M775-3]
CCDS58531.1 [Q5M775-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001028725.1, NM_001033553.2 [Q5M775-1]
NP_001028726.1, NM_001033554.2 [Q5M775-3]
NP_001028727.1, NM_001033555.2 [Q5M775-4]
NP_001230367.1, NM_001243438.1 [Q5M775-5]
NP_001230368.1, NM_001243439.1 [Q5M775-1]
NP_690868.3, NM_152904.4 [Q5M775-2]
XP_016880814.1, XM_017025325.1 [Q5M775-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261503; ENSP00000261503; ENSG00000128487 [Q5M775-1]
ENST00000395522; ENSP00000378893; ENSG00000128487 [Q5M775-5]
ENST00000395525; ENSP00000378896; ENSG00000128487 [Q5M775-3]
ENST00000395527; ENSP00000378898; ENSG00000128487 [Q5M775-1]
ENST00000395529; ENSP00000378900; ENSG00000128487 [Q5M775-2]
ENST00000395530; ENSP00000378901; ENSG00000128487 [Q5M775-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92521

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92521

UCSC genome browser

More...
UCSCi
uc002gwq.4 human [Q5M775-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041533 mRNA Translation: BAB16440.1 Frameshift.
AY816326 mRNA Translation: AAW29999.1
AY816327 mRNA Translation: AAW30000.1
AY816328 mRNA Translation: AAW30001.1
AY816329 mRNA Translation: AAW30002.1
BK005598 Genomic DNA Translation: DAA05629.1
BK005598 Genomic DNA Translation: DAA05630.1
BK005598 Genomic DNA Translation: DAA05631.1
BK005598 Genomic DNA Translation: DAA05632.1
AK295093 mRNA Translation: BAG58132.1
AC005730 Genomic DNA No translation available.
BC021123 mRNA Translation: AAH21123.2
BC033618 mRNA Translation: AAH33618.1 Different initiation.
BC050058 mRNA Translation: AAH50058.1
CCDSiCCDS32590.1 [Q5M775-1]
CCDS42280.1 [Q5M775-2]
CCDS42281.1 [Q5M775-4]
CCDS45628.1 [Q5M775-3]
CCDS58531.1 [Q5M775-5]
RefSeqiNP_001028725.1, NM_001033553.2 [Q5M775-1]
NP_001028726.1, NM_001033554.2 [Q5M775-3]
NP_001028727.1, NM_001033555.2 [Q5M775-4]
NP_001230367.1, NM_001243438.1 [Q5M775-5]
NP_001230368.1, NM_001243439.1 [Q5M775-1]
NP_690868.3, NM_152904.4 [Q5M775-2]
XP_016880814.1, XM_017025325.1 [Q5M775-2]

3D structure databases

SMRiQ5M775
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124953, 68 interactors
IntActiQ5M775, 50 interactors
STRINGi9606.ENSP00000261503

PTM databases

iPTMnetiQ5M775
PhosphoSitePlusiQ5M775

Polymorphism and mutation databases

BioMutaiSPECC1
DMDMi74722683

Proteomic databases

EPDiQ5M775
jPOSTiQ5M775
MaxQBiQ5M775
PaxDbiQ5M775
PeptideAtlasiQ5M775
PRIDEiQ5M775
ProteomicsDBi63559 [Q5M775-1]
63560 [Q5M775-2]
63561 [Q5M775-3]
63562 [Q5M775-4]
63563 [Q5M775-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261503; ENSP00000261503; ENSG00000128487 [Q5M775-1]
ENST00000395522; ENSP00000378893; ENSG00000128487 [Q5M775-5]
ENST00000395525; ENSP00000378896; ENSG00000128487 [Q5M775-3]
ENST00000395527; ENSP00000378898; ENSG00000128487 [Q5M775-1]
ENST00000395529; ENSP00000378900; ENSG00000128487 [Q5M775-2]
ENST00000395530; ENSP00000378901; ENSG00000128487 [Q5M775-4]
GeneIDi92521
KEGGihsa:92521
UCSCiuc002gwq.4 human [Q5M775-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92521
DisGeNETi92521

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPECC1
HGNCiHGNC:30615 SPECC1
HPAiHPA021421
HPA021430
MIMi608793 gene
neXtProtiNX_Q5M775
OpenTargetsiENSG00000128487
PharmGKBiPA164718712

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4678 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000153592
InParanoidiQ5M775
KOiK23028
OMAiIYLEHSP
PhylomeDBiQ5M775
TreeFamiTF316716

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPECC1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPECC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92521

Protein Ontology

More...
PROi
PR:Q5M775

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128487 Expressed in 153 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ5M775 baseline and differential
GenevisibleiQ5M775 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYTSB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5M775
Secondary accession number(s): B4DHH0
, B7WNS8, Q5IBP1, Q5IBP2, Q5IBP3, Q5IBP4, Q5M772, Q5M773, Q5M774, Q86XT8, Q8N4U4, Q8WU84, Q9HCQ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 1, 2005
Last modified: July 31, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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