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Entry version 82 (31 Jul 2019)
Sequence version 2 (03 May 2011)
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Protein

Vacuolar protein sorting-associated protein 22 homolog 1

Gene

VP22-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 22 homolog 1
Short name:
AtVPS22-1
Alternative name(s):
ESCRT-II complex subunit VPS22 homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VP22-1
Ordered Locus Names:At4g27040
ORF Names:F10M23.380
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G27040

The Arabidopsis Information Resource

More...
TAIRi
locus:2116357 AT4G27040

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003681911 – 250Vacuolar protein sorting-associated protein 22 homolog 1Add BLAST250

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5M759

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5M759 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5M759 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of VPS22, VPS25 and VPS36.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
14099, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q5M759, 5 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT4G27040.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5M759

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili35 – 55Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 16Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3341 Eukaryota
ENOG410XPVM LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000170930

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5M759

KEGG Orthology (KO)

More...
KOi
K12188

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQFARMC

Database of Orthologous Groups

More...
OrthoDBi
869548at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016689 ESCRT-2_cplx_Snf8
IPR040608 Snf8/Vps36
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12806 PTHR12806, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04157 EAP30, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017215 ESCRT2_Vps22, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5M759-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRRPGIGGL QKAAAARDQY RLLGENVAKL RTDMMKEQLS TFRSQLEEFA
60 70 80 90 100
RKHKNDIRKN PAFRAQFHEM CANIGVDPLA SNKGFWAELL GIGDFYYELG
110 120 130 140 150
VQIIEVCMLT RSHNGGLISL QELCNHLRQR RKKDREAVTE DDCLRAISKL
160 170 180 190 200
KVLGSGFEVI TIGKKKLVRS VPTELNKDHN QILELAQGQG FVIVEEVQRR
210 220 230 240 250
LSWTSGRVID ALETLLEEGL AMIDNGHKDG KCRYWFPCVS SVYSSIGSDT
Length:250
Mass (Da):28,310
Last modified:May 3, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BED008163F0C744
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB36550 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79559 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17R → G in AAV91335 (Ref. 4) Curated1
Sequence conflicti17R → G in AAW70398 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL035440 Genomic DNA Translation: CAB36550.1 Sequence problems.
AL161566 Genomic DNA Translation: CAB79559.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85287.1
CP002687 Genomic DNA Translation: AEE85288.1
CP002687 Genomic DNA Translation: AEE85289.1
CP002687 Genomic DNA Translation: AEE85290.1
CP002687 Genomic DNA Translation: ANM66725.1
CP002687 Genomic DNA Translation: ANM66726.1
AY299265 mRNA No translation available.
BT020389 mRNA Translation: AAV91335.1
BT020552 mRNA Translation: AAW70398.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T04827

NCBI Reference Sequences

More...
RefSeqi
NP_001119065.1, NM_001125593.1
NP_001119066.1, NM_001125594.1
NP_001119067.1, NM_001125595.2
NP_001328603.1, NM_001341835.1
NP_001328604.1, NM_001341834.1
NP_194434.2, NM_118838.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G27040.1; AT4G27040.1; AT4G27040
AT4G27040.2; AT4G27040.2; AT4G27040
AT4G27040.3; AT4G27040.3; AT4G27040
AT4G27040.4; AT4G27040.4; AT4G27040
AT4G27040.5; AT4G27040.5; AT4G27040
AT4G27040.6; AT4G27040.6; AT4G27040

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
828812

Gramene; a comparative resource for plants

More...
Gramenei
AT4G27040.1; AT4G27040.1; AT4G27040
AT4G27040.2; AT4G27040.2; AT4G27040
AT4G27040.3; AT4G27040.3; AT4G27040
AT4G27040.4; AT4G27040.4; AT4G27040
AT4G27040.5; AT4G27040.5; AT4G27040
AT4G27040.6; AT4G27040.6; AT4G27040

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G27040

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035440 Genomic DNA Translation: CAB36550.1 Sequence problems.
AL161566 Genomic DNA Translation: CAB79559.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85287.1
CP002687 Genomic DNA Translation: AEE85288.1
CP002687 Genomic DNA Translation: AEE85289.1
CP002687 Genomic DNA Translation: AEE85290.1
CP002687 Genomic DNA Translation: ANM66725.1
CP002687 Genomic DNA Translation: ANM66726.1
AY299265 mRNA No translation available.
BT020389 mRNA Translation: AAV91335.1
BT020552 mRNA Translation: AAW70398.1
PIRiT04827
RefSeqiNP_001119065.1, NM_001125593.1
NP_001119066.1, NM_001125594.1
NP_001119067.1, NM_001125595.2
NP_001328603.1, NM_001341835.1
NP_001328604.1, NM_001341834.1
NP_194434.2, NM_118838.5

3D structure databases

SMRiQ5M759
ModBaseiSearch...

Protein-protein interaction databases

BioGridi14099, 6 interactors
IntActiQ5M759, 5 interactors
STRINGi3702.AT4G27040.2

Proteomic databases

PaxDbiQ5M759

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
828812

Genome annotation databases

EnsemblPlantsiAT4G27040.1; AT4G27040.1; AT4G27040
AT4G27040.2; AT4G27040.2; AT4G27040
AT4G27040.3; AT4G27040.3; AT4G27040
AT4G27040.4; AT4G27040.4; AT4G27040
AT4G27040.5; AT4G27040.5; AT4G27040
AT4G27040.6; AT4G27040.6; AT4G27040
GeneIDi828812
GrameneiAT4G27040.1; AT4G27040.1; AT4G27040
AT4G27040.2; AT4G27040.2; AT4G27040
AT4G27040.3; AT4G27040.3; AT4G27040
AT4G27040.4; AT4G27040.4; AT4G27040
AT4G27040.5; AT4G27040.5; AT4G27040
AT4G27040.6; AT4G27040.6; AT4G27040
KEGGiath:AT4G27040

Organism-specific databases

AraportiAT4G27040
TAIRilocus:2116357 AT4G27040

Phylogenomic databases

eggNOGiKOG3341 Eukaryota
ENOG410XPVM LUCA
HOGENOMiHOG000170930
InParanoidiQ5M759
KOiK12188
OMAiAQFARMC
OrthoDBi869548at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5M759

Gene expression databases

ExpressionAtlasiQ5M759 baseline and differential
GenevisibleiQ5M759 AT

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR016689 ESCRT-2_cplx_Snf8
IPR040608 Snf8/Vps36
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12806 PTHR12806, 1 hit
PfamiView protein in Pfam
PF04157 EAP30, 1 hit
PIRSFiPIRSF017215 ESCRT2_Vps22, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP221_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5M759
Secondary accession number(s): Q9SZ43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 3, 2011
Last modified: July 31, 2019
This is version 82 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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